The transcription factorPax6is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+dynamics in adult mice

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

(2016) Alice E. Adriaenssens et al.   DIABETOLOGIA

Pancreatic β cell identity requires continual repression of non–β cell programs

(2016) Giselle Domínguez Gutiérrez et al.   JOURNAL OF CLINICAL INVESTIGATION

PAX6 maintains β cell identity by repressing genes of alternative islet cell types

(2016) Avital Swisa et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Genetic Regulation ofSlc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance

(2016) Ryan K. Mitchell et al.   MOLECULAR ENDOCRINOLOGY

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

(2015) Guy A. Rutter et al.   BIOCHEMICAL JOURNAL

Phenotypic Characterization of MIP-CreERT1LphiMice With Transgene-Driven Islet Expression of Human Growth Hormone

(2015) Daniel Oropeza et al.   DIABETES

Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass

(2015) Pierre-Jacques Brun et al.   FASEB JOURNAL

Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion

(2015) Jia Li et al.   FASEB JOURNAL

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion

(2015) Antonia Solomou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DICER Inactivation Identifies Pancreatic β-Cell “Disallowed” Genes Targeted by MicroRNAs

(2015) Aida Martinez-Sanchez et al.   MOLECULAR ENDOCRINOLOGY

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells

(2015) Helen Soedling et al.   Molecular Metabolism

Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker

(2015) Zeeshan Ahmad et al.   PLoS One

Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

(2014) Guy A. Rutter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ADCY5 Couples Glucose to Insulin Secretion in Human Islets

(2014) D. J. Hodson et al.   DIABETES

High-fat diet induces early-onset diabetes in heterozygousPax6mutant mice

(2014) Yuanyuan Chen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

LKB1 and AMPK differentially regulate pancreatic β-cell identity

(2014) Marina Kone et al.   FASEB JOURNAL

Incretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans

(2014) David J. Hodson et al.   MOLECULAR ENDOCRINOLOGY

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

(2014) J. Fadista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics

(2014) Richard K.P. Benninger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

(2014) Melissa F. Brereton et al.   Nature Communications

Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells

(2014) Julie Piccand et al.   Cell Reports

Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose

(2013) Richard M. O’Brien   Current Diabetes Reports

Lipotoxicity disrupts incretin-regulated human β cell connectivity

(2013) David J. Hodson et al.   JOURNAL OF CLINICAL INVESTIGATION

KATP channels and islet hormone secretion: new insights and controversies

(2013) Frances M. Ashcroft et al.   Nature Reviews Endocrinology

The Developmental Regulator Pax6 Is Essential for Maintenance of Islet Cell Function in the Adult Mouse Pancreas

(2013) Alan W. Hart et al.   PLoS One

A Review of the Clinical and Genetic Aspects of Aniridia

(2013) Hyunjoo J. Lee et al.   Seminars in Ophthalmology

Regulation of ATP production by mitochondrial Ca2+

(2012) Andrei I. Tarasov et al.   CELL CALCIUM

Overexpression of Monocarboxylate Transporter-1 (Slc16a1) in Mouse Pancreatic  -Cells Leads to Relative Hyperinsulinism During Exercise

(2012) T. J. Pullen et al.   DIABETES

When less is more: the forbidden fruits of gene repression in the adult β-cell

(2012) T. J. Pullen et al.   DIABETES OBESITY & METABOLISM

Subpopulations of GFP-Marked Mouse Pancreatic β-Cells Differ in Size, Granularity, and Insulin Secretion

(2012) Hitoshi Katsuta et al.   ENDOCRINOLOGY

Pax6 Is Crucial for β-Cell Function, Insulin Biosynthesis, and Glucose-Induced Insulin Secretion

(2012) Yvan Gosmain et al.   MOLECULAR ENDOCRINOLOGY

The Mitochondrial Ca2+ Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells

(2012) Andrei I. Tarasov et al.   PLoS One

Existence of long-lasting experience-dependent plasticity in endocrine cell networks

(2012) David J. Hodson et al.   Nature Communications

Structure, Mechanism, and Evolution of Ero1 Family Enzymes

(2011) Kazutaka Araki et al.   ANTIOXIDANTS & REDOX SIGNALING

A common variant upstream of the PAX6 gene influences islet function in man

(2011) E. Ahlqvist et al.   DIABETOLOGIA

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis

(2010) G. Sun et al.   Disease Models & Mechanisms

Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation

(2010) L. Thorrez et al.   GENOME RESEARCH

Pax6 Controls the Expression of Critical Genes Involved in Pancreatic α Cell Differentiation and Function

(2010) Yvan Gosmain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rfx6 directs islet formation and insulin production in mice and humans

(2010) Stuart B. Smith et al.   NATURE

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

Regulation of insulin secretion: a matter of phase control and amplitude modulation

(2009) J. C. Henquin   DIABETOLOGIA

A genetically encoded fluorescent reporter of ATP:ADP ratio

(2009) Jim Berg et al.   NATURE METHODS

Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice

(2009) T Ian Simpson et al.   Neural Development

Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3)

(2008) J. H. Wen et al.   DIABETOLOGIA