Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

(2011) Sangeeta Dhawan et al.   DEVELOPMENTAL CELL

Context-specific  -to- -cell reprogramming by forced Pdx1 expression

(2011) Y.-P. Yang et al.   GENES & DEVELOPMENT

Nkx2.2 repressor complex regulates islet  -cell specification and prevents  -to- -cell reprogramming

(2011) J. B. Papizan et al.   GENES & DEVELOPMENT

Islet-1 RegulatesArxTranscription during Pancreatic Islet α-Cell Development

(2011) Jingxuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NKX6.1 Promotes PDX-1-Induced Liver to Pancreatic β-Cells Reprogramming

(2010) Shiraz Gefen-Halevi et al.   Cellular Reprogramming

Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors

(2010) Ashleigh E. Schaffer et al.   DEVELOPMENTAL CELL

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Pancreatic neurogenin 3-expressing cells are unipotent islet precursors

(2009) R. Desgraz et al.   DEVELOPMENT

Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas

(2009) Sui Wang et al.   DEVELOPMENTAL BIOLOGY

Gene Therapy with Neurogenin 3 and Betacellulin Reverses Major Metabolic Problems in Insulin-Deficient Diabetic Mice

(2009) Vijay Yechoor et al.   ENDOCRINOLOGY

Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window

(2009) C. Cras-Meneur et al.   GENES & DEVELOPMENT

A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation

(2008) Philip A. Seymour et al.   DEVELOPMENTAL BIOLOGY

pdx-1 function is specifically required in embryonic β cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

(2008) Maureen Gannon et al.   DEVELOPMENTAL BIOLOGY

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY