Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Endoplasmic Reticulum Stress in Malignancy

(2014) Hanna J. Clarke et al.   CANCER CELL

Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis

(2014) Shan Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Hepatoprotective role of Sestrin2 against chronic ER stress

(2014) Hwan-Woo Park et al.   Nature Communications

Aberrant islet unfolded protein response in type 2 diabetes

(2014) Feyza Engin et al.   Scientific Reports

Orchestration of secretory protein folding by ER chaperones

(2013) Tali Gidalevitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

In vivo activating transcription factor 3 silencing ameliorates the AMPK compensatory effects for ER stress-mediated β-cell dysfunction during the progression of type-2 diabetes

(2013) Ji Yeon Kim et al.   CELLULAR SIGNALLING

Hydroxynaphthoic Acids Identified in a High Throughput Screening Potently Ameliorate Endoplasmic Reticulum Stress as Novel Chemical Chaperones

(2013) Kwi-wan Jeong et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Targeting endoplasmic reticulum stress in metabolic disease

(2013) Stewart Siyan Cao et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing

(2013) Isin Çakir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue

(2013) Ahmed Bettaieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Unfolded Protein Response in Vascular Endothelial Cells of Nondiabetic Obese Adults

(2013) Rachelle E. Kaplon et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

Endoplasmic reticulum stress preconditioning attenuates methylmercury-induced cellular damage by inducing favorable stress responses

(2013) Fusako Usuki et al.   Scientific Reports

TRPM2 Ca2+ channel regulates energy balance and glucose metabolism

(2012) Zhiyou Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice

(2012) Ding Ai et al.   JOURNAL OF CLINICAL INVESTIGATION

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes

(2012) Yiguo Wang et al.   NATURE

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

(2012) Likun Wang et al.   Nature Chemical Biology

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

(2011) Abdelali Agouni et al.   BIOCHEMICAL JOURNAL

Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans

(2011) Changting Xiao et al.   DIABETES

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

PKA phosphorylation couples hepatic inositol-requiring enzyme 1  to glucagon signaling in glucose metabolism

(2011) T. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice

(2010) Mathieu Latreille et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases

(2010) F. Engin et al.   DIABETES OBESITY & METABOLISM

Preconditioning with Endoplasmic Reticulum Stress Mitigates Retinal Endothelial Inflammation via Activation of X-box Binding Protein 1

(2010) Jingming Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic reticulum stress and atherosclerosis

(2010) Gökhan S Hotamisligil   NATURE MEDICINE

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

(2010) M. S. Gorbatyuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals

(2009) K. Mori   JOURNAL OF BIOCHEMISTRY

The Protein Folding Problem

(2008) Ken A. Dill et al.   Annual Review of Biophysics

How IRE1 Reacts to ER Stress

(2008) David Ron et al.   CELL

Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

Endoplasmic Reticulum Stress Markers Are Associated with Obesity in Nondiabetic Subjects

(2008) Neeraj K. Sharma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Preconditioning with Endoplasmic Reticulum Stress Ameliorates Mesangioproliferative Glomerulonephritis

(2008) R. Inagi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY