Are we overestimating the loss of beta cells in type 2 diabetes?

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans

(2012) J. J. Meier et al.   DIABETOLOGIA

Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2012) S. E. Inzucchi et al.   DIABETOLOGIA

Effects of Bariatric Surgery on Glucose Homeostasis and Type 2 Diabetes

(2012) David Bradley et al.   GASTROENTEROLOGY

Altered Islet Composition and Disproportionate Loss of Large Islets in Patients with Type 2 Diabetes

(2011) German Kilimnik et al.   PLoS One

Histopathology and ex vivo insulin secretion of pancreatic islets in gestational diabetes: A case report

(2011) Mariella Tancredi et al.   Islets

β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes

(2010) Stephen C. Hanley et al.   ENDOCRINOLOGY

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

Goals of Treatment for Type 2 Diabetes:  -Cell preservation for glycemic control

(2009) P. Marchetti et al.   DIABETES CARE

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Beta cell mass in diabetes: a realistic therapeutic target?

(2008) J. J. Meier   DIABETOLOGIA

Weighing up β-cell mass in mice and humans: Self-renewal, progenitors or stem cells?

(2008) Neil A. Hanley et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY