Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer
出版年份 2022 全文链接
标题
Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer
作者
关键词
Immune checkpoint, Tumor metabolism, Immunotherapy, Tumor microenvironment, Glycolysis, Amine acid metabolism, Lipid metabolism, Fatty acid synthesis
出版物
SEMINARS IN CANCER BIOLOGY
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2022-02-11
DOI
10.1016/j.semcancer.2022.02.010
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Phase II trial of nivolumab and metformin in patients with treatment refractory microsatellite stable metastatic colorectal cancer.
- (2021) Mehmet Akce et al. JOURNAL OF CLINICAL ONCOLOGY
- Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity
- (2021) Ke Xu et al. SCIENCE
- Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
- (2021) Zhaohan Wei et al. Nature Communications
- Glucose metabolism involved in PD-L1-mediated immune escape in the malignant kidney tumour microenvironment
- (2021) Yongbo Yu et al. Cell Death Discovery
- CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability
- (2021) Xingzhe Ma et al. Cell Metabolism
- Combined inhibition of PD-1/PD-L1, Lag-3, and Tim-3 axes augments antitumor immunity in gastric cancer–T cell coculture models
- (2021) Kosaku Mimura et al. Gastric Cancer
- Lipid signalling enforces functional specialization of Treg cells in tumours
- (2021) Seon Ah Lim et al. NATURE
- Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy
- (2021) Xin Peng et al. Frontiers in Immunology
- Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model
- (2021) Veronika Voronova et al. Frontiers in Immunology
- Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses
- (2021) Ke Xu et al. IMMUNITY
- Clinical Insights Into Novel Immune Checkpoint Inhibitors
- (2021) Jii Bum Lee et al. Frontiers in Pharmacology
- Inhibition of LDH-A by Oxamate Enhances the Efficacy of Anti-PD-1 Treatment in an NSCLC Humanized Mouse Model
- (2021) Tianyun Qiao et al. Frontiers in Oncology
- Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors
- (2021) Shihao Xu et al. IMMUNITY
- Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2–3 study
- (2021) Zhenggang Ren et al. LANCET ONCOLOGY
- Tumor microenvironment-responsive prodrug nanoplatform via co-self-assembly of photothermal agent and IDO inhibitor for enhanced tumor penetration and cancer immunotherapy
- (2020) Yijia Liu et al. BIOMATERIALS
- 6-Gingerol induces cell-cycle G1-phase arrest through AKT–GSK 3β–cyclin D1 pathway in renal-cell carcinoma
- (2020) Shan Xu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Aberrant lipid metabolism in hepatocellular carcinoma cells as well as immune microenvironment: A review
- (2020) Bo Hu et al. CELL PROLIFERATION
- A phase Ib study of troriluzole (BHV-4157) in combination with nivolumab.
- (2020) Ann W. Silk et al. JOURNAL OF CLINICAL ONCOLOGY
- Adenosine receptor blockade with ciforadenant +/- atezolizumab in advanced metastatic castration-resistant prostate cancer (mCRPC).
- (2020) Lauren Christine Harshman et al. JOURNAL OF CLINICAL ONCOLOGY
- Durvalumab as neoadjuvant therapy for muscle-invasive bladder cancer: Preliminary results from the Bladder Cancer Signal Seeking Trial (BLASST)-2.
- (2020) Xiao X. Wei et al. JOURNAL OF CLINICAL ONCOLOGY
- Comprehensive analysis of the association between tumor glycolysis and immune/inflammation function in breast cancer
- (2020) Wenhui Li et al. Journal of Translational Medicine
- Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy
- (2020) Daixi Ren et al. Molecular Cancer
- Saccharide analog, 2‐deoxy‐ d ‐glucose enhances 4‐1BB‐mediated antitumor immunity via PD‐L1 deglycosylation
- (2020) Bareun Kim et al. MOLECULAR CARCINOGENESIS
- CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors
- (2020) Haiping Wang et al. NATURE IMMUNOLOGY
- Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma
- (2020) Terai et al. Cancers
- Targeted deletion of PD-1 in myeloid cells induces antitumor immunity
- (2020) Laura Strauss et al. Science Immunology
- Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism
- (2020) Alexander Duscha et al. CELL
- A comprehensive analysis of IDO1 expression with tumour‐infiltrating immune cells and mutation burden in gynaecologic and breast cancers
- (2020) Xu Feng et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers
- (2020) Myriam Chalabi et al. NATURE MEDICINE
- TNIK signaling imprints CD8+ T cell memory formation early after priming
- (2020) Carla A. Jaeger-Ruckstuhl et al. Nature Communications
- Effective combinatorial immunotherapy for penile squamous cell carcinoma
- (2020) Tianhe Huang et al. Nature Communications
- Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
- (2020) Clélia Coutzac et al. Nature Communications
- Jet‐Lagged Nanoparticles Enhanced Immunotherapy Efficiency through Synergistic Reconstruction of Tumor Microenvironment and Normalized Tumor Vasculature
- (2020) Zhijie Jiang et al. Advanced Healthcare Materials
- Tumor‐Targeted Inhibition of Monocarboxylate Transporter 1 Improves T‐Cell Immunotherapy of Solid Tumors
- (2020) Tongyi Huang et al. Advanced Healthcare Materials
- Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells
- (2020) Fernando Erra Díaz et al. Cell Reports
- Specific Polyunsaturated Fatty Acids Can Modulate in vitro Human moDC2s and Subsequent Th2 Cytokine Release
- (2020) Tamara Hoppenbrouwers et al. Frontiers in Immunology
- Lung Tumor Cell-Derived Exosomes Promote M2 Macrophage Polarization
- (2020) Alexandra Pritchard et al. Cells
- TIGIT expression is associated with T-cell suppression and exhaustion and predicts clinical outcome and anti-PD-1 response in follicular lymphoma
- (2020) Zhi-Zhang Yang et al. CLINICAL CANCER RESEARCH
- The safety and tolerability of epacadostat alone and in combination with pembrolizumab in patients with advanced solid tumors: results from a first-in-Japanese phase I study (KEYNOTE-434)
- (2020) Toshihiko Doi et al. INVESTIGATIONAL NEW DRUGS
- LAG3 (CD223) and autoimmunity: Emerging evidence
- (2020) Suiyuan Hu et al. JOURNAL OF AUTOIMMUNITY
- Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen
- (2020) Santosha A. Vardhana et al. NATURE IMMUNOLOGY
- Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors
- (2020) Lorenzo Galluzzi et al. Nature Reviews Clinical Oncology
- Comprehensive Analysis of the Expressionand Prognosis for TDO2 in Breast Cancer
- (2020) Qiang Liu et al. Molecular Therapy-Oncolytics
- Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity
- (2020) Alexandra Borodovsky et al. Journal for ImmunoTherapy of Cancer
- Association of TIM-3 expression with glucose metabolism in Jurkat T cells
- (2020) Mi Jin Lee et al. BMC IMMUNOLOGY
- 6‐Gingerol suppresses tumor cell metastasis by increasing YAP ser127 phosphorylation in renal cell carcinoma
- (2020) Shan Xu et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis
- (2020) Jian-Wei Hao et al. Nature Communications
- Shaping of Dendritic Cell Function by the Metabolic Micro-Environment
- (2020) Eline Constance Brombacher et al. Frontiers in Endocrinology
- TIGIT in cancer immunotherapy
- (2020) Joe-Marc Chauvin et al. Journal for ImmunoTherapy of Cancer
- Cancer Acidity and Hypertonicity Contribute to Dysfunction of Tumor-Associated Dendritic Cells: Potential Impact on Antigen Cross-Presentation Machinery
- (2020) Sven Burgdorf et al. Cancers
- Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer
- (2020) Weiqiang Lu et al. EMBO Molecular Medicine
- The glutaminase inhibitor CB-839 (Telaglenastat) enhances the anti-melanoma activity of T cell mediated immunotherapies.
- (2020) Sruthy Varghese et al. MOLECULAR CANCER THERAPEUTICS
- Enhancing anti-tumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors
- (2019) K M Heinhuis et al. ANNALS OF ONCOLOGY
- DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane
- (2019) Juan Wang et al. Cell Reports
- Phase 1/2 study of epacadostat in combination with ipilimumab in patients with unresectable or metastatic melanoma
- (2019) Geoffrey T. Gibney et al. Journal for ImmunoTherapy of Cancer
- Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
- (2019) Xiaoyun Li et al. Nature Reviews Clinical Oncology
- BMS-986205, an indoleamine 2, 3-dioxygenase 1 inhibitor (IDO1i), in combination with nivolumab (nivo): Updated safety across all tumor cohorts and efficacy in advanced bladder cancer (advBC).
- (2019) Jason J. Luke et al. JOURNAL OF CLINICAL ONCOLOGY
- Amino acid metabolism as drug target in autoimmune diseases
- (2019) Giada Mondanelli et al. AUTOIMMUNITY REVIEWS
- Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial
- (2019) Howard West et al. LANCET ONCOLOGY
- Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells
- (2019) Fei Chen et al. NATURE CELL BIOLOGY
- PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
- (2019) Takahiro Kamada et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
- (2019) Mark R Sullivan et al. eLife
- Targeting hypoxia-induced carbonic anhydrase IX enhances immune checkpoint blockade locally and systemically
- (2019) Shawn C Chafe et al. Cancer Immunology Research
- Macrophages and Metabolism in the Tumor Microenvironment
- (2019) Ilio Vitale et al. Cell Metabolism
- Competition for nutrients and its role in controlling immune responses
- (2019) Nidhi Kedia-Mehta et al. Nature Communications
- Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma
- (2019) Malgorzata Czystowska-Kuzmicz et al. Nature Communications
- Metabolic Control of Dendritic Cell Functions: Digesting Information
- (2019) Stefanie K. Wculek et al. Frontiers in Immunology
- Dual PD ‐1 and VEGFR ‐2 blockade promotes vascular normalization and enhances anti‐tumor immune responses in HCC
- (2019) Kohei Shigeta et al. HEPATOLOGY
- Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study
- (2019) Georgina V Long et al. LANCET ONCOLOGY
- Dendritic Cell Metabolism and Function in Tumors
- (2019) Paolo Giovanelli et al. TRENDS IN IMMUNOLOGY
- T Cell Activation Depends on Extracellular Alanine
- (2019) Noga Ron-Harel et al. Cell Reports
- Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer
- (2019) Wen-Chao Wu et al. Cancer Immunology Research
- PD-1 and LAG-3 Dominate Checkpoint Receptor–Mediated T-cell Inhibition in Renal Cell Carcinoma
- (2019) Henning Zelba et al. Cancer Immunology Research
- Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells
- (2019) Marco Gargaro et al. Frontiers in Immunology
- 440OPhase I study of the arginase inhibitor INCB001158 (1158) alone and in combination with pembrolizumab (PEM) in patients (Pts) with advanced/metastatic (adv/met) solid tumours
- (2019) A Naing et al. ANNALS OF ONCOLOGY
- LBA47Randomized, open-label, perioperative phase II study evaluating nivolumab alone versus nivolumab plus ipilimumab in patients with resectable HCC
- (2019) A Kaseb et al. ANNALS OF ONCOLOGY
- LBA8_PRKEYNOTE-522: Phase III study of pembrolizumab (pembro) + chemotherapy (chemo) vs placebo (pbo) + chemo as neoadjuvant treatment, followed by pembro vs pbo as adjuvant treatment for early triple-negative breast cancer (TNBC)
- (2019) P Schmid et al. ANNALS OF ONCOLOGY
- Ammonia mediates mitochondrial uncoupling and promotes glycolysis via HIF-1 activation in human breast cancer MDA-MB-231 cells
- (2019) Yapeng Lu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Adding indoximod to hypofractionated radiotherapy with anti-PD-1 checkpoint blockade enhances early NK and CD8+ T cell-dependent tumor activity
- (2019) Tsubasa Watanabe et al. CLINICAL CANCER RESEARCH
- Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages
- (2019) Hao Wu et al. EMBO Molecular Medicine
- Role of Inducible Co-Stimulator (ICOS) in cancer immunotherapy
- (2019) Florent Amatore et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- PD-1/PD-L1 pathway activation restores the imbalance of Th1/Th2 and treg/Th17 cells subtypes in immune thrombocytopenic purpura patients
- (2019) Die Wu et al. MEDICINE
- Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4
- (2019) Shuang Qin et al. Molecular Cancer
- VISTA is an acidic pH-selective ligand for PSGL-1
- (2019) Robert J. Johnston et al. NATURE
- Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups
- (2019) Lawrence P. Andrews et al. NATURE IMMUNOLOGY
- Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
- (2019) Cameron S. Field et al. Cell Metabolism
- ENERGIZE: a Phase III study of neoadjuvant chemotherapy alone or with nivolumab with/without linrodostat mesylate for muscle-invasive bladder cancer
- (2019) Guru Sonpavde et al. Future Oncology
- Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy
- (2019) Nikita S. Sharma et al. JOURNAL OF CLINICAL INVESTIGATION
- Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon
- (2019) Timothy P. Brown et al. PHARMACOLOGY & THERAPEUTICS
- Tumor-Repopulating Cells Induce PD-1 Expression in CD8 + T Cells by Transferring Kynurenine and AhR Activation
- (2018) Yuying Liu et al. CANCER CELL
- Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship
- (2018) Romana T. Netea-Maier et al. CANCER LETTERS
- Downregulation of Membrane Trafficking Proteins and Lactate Conditioning Determine Loss of Dendritic Cell Function in Lung Cancer
- (2018) Nicoletta Caronni et al. CANCER RESEARCH
- NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control
- (2018) Jan P. Böttcher et al. CELL
- Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
- (2018) Tina Cascone et al. Cell Metabolism
- Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer
- (2018) Wei Li et al. Cell Metabolism
- Cancer-associated fibroblasts in tumor microenvironment – Accomplices in tumor malignancy
- (2018) Zehuan Liao et al. CELLULAR IMMUNOLOGY
- Novel effector phenotype of Tim-3+ regulatory T cells leads to enhanced suppressive function in head and neck cancer patients
- (2018) Zhuqing Liu et al. CLINICAL CANCER RESEARCH
- Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization
- (2018) Fei Zhao et al. IMMUNITY
- mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+Regulatory T Cells
- (2018) Im-Hong Sun et al. JOURNAL OF IMMUNOLOGY
- Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study
- (2018) Giuseppe Giaccone et al. LANCET ONCOLOGY
- Fatty acid oxidation contributes to IL-1β secretion in M2 macrophages and promotes macrophage-mediated tumor cell migration
- (2018) Qi Zhang et al. MOLECULAR IMMUNOLOGY
- Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity
- (2018) Qing Zhang et al. NATURE IMMUNOLOGY
- A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
- (2018) Daniela S. Thommen et al. NATURE MEDICINE
- Safety of combining radiotherapy with immune-checkpoint inhibition
- (2018) William L. Hwang et al. Nature Reviews Clinical Oncology
- Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer
- (2018) Leena Gandhi et al. NEW ENGLAND JOURNAL OF MEDICINE
- The nutrient environment affects therapy
- (2018) Alexander Muir et al. SCIENCE
- Cancer immunotherapy using checkpoint blockade
- (2018) Antoni Ribas et al. SCIENCE
- Targeting the IDO1/TDO2–KYN–AhR Pathway for Cancer Immunotherapy – Challenges and Opportunities
- (2018) Jae Eun Cheong et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
- (2018) Fu-Long Li et al. Nature Communications
- Lipid Accumulation in Peripheral Blood Dendritic Cells and Anticancer Immunity in Patients with Lung Cancer
- (2018) Ryo Arai et al. Journal of Immunology Research
- Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy
- (2018) Soumaya Kouidhi et al. Frontiers in Immunology
- Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors
- (2018) Asha Nayak-Kapoor et al. Journal for ImmunoTherapy of Cancer
- Metabolic Stress in the Immune Function of T Cells, Macrophages and Dendritic Cells
- (2018) Charlotte Domblides et al. Cells
- The impact of metabolic reprogramming on dendritic cell function
- (2018) Livia de Lima Thomaz et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Superior efficacy of neoadjuvant chemotherapy and radical cystectomy in cT3-4aN0M0 compared to cT2N0M0 bladder cancer
- (2018) T.J.N. Hermans et al. INTERNATIONAL JOURNAL OF CANCER
- Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037)
- (2018) Tara C. Mitchell et al. JOURNAL OF CLINICAL ONCOLOGY
- Neoadjuvant chemo/immunotherapy for the treatment of stages IIIA resectable non-small cell lung cancer (NSCLC): A phase II multicenter exploratory study—NADIM study-SLCG.
- (2018) Mariano Provencio-Pulla et al. JOURNAL OF CLINICAL ONCOLOGY
- Epacadostat plus nivolumab for advanced melanoma: Updated phase 2 results of the ECHO-204 study.
- (2018) Adil Daud et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase 2 trial of the IDO pathway inhibitor indoximod plus checkpoint inhibition for the treatment of patients with advanced melanoma.
- (2018) Yousef Zakharia et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase 3 study of carboplatin-paclitaxel/nab-paclitaxel (Chemo) with or without pembrolizumab (Pembro) for patients (Pts) with metastatic squamous (Sq) non-small cell lung cancer (NSCLC).
- (2018) Luis G. Paz-Ares et al. JOURNAL OF CLINICAL ONCOLOGY
- BMS-986205, an indoleamine 2,3-dioxygenase 1 inhibitor (IDO1i), in combination with nivolumab (NIVO): Updated safety across all tumor cohorts and efficacy in pts with advanced bladder cancer (advBC).
- (2018) Josep Tabernero et al. JOURNAL OF CLINICAL ONCOLOGY
- Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy
- (2018) Bruno Gomes et al. MOLECULAR CANCER THERAPEUTICS
- Regulation of Fatty Acid Synthesis in Immune Cells
- (2018) Xuchen Qian et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
- (2018) Spencer C. Wei et al. Cancer Discovery
- PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8+ T cells and facilitates anti-PD-1 therapy
- (2018) Partha S. Chowdhury et al. Cancer Immunology Research
- GITR Agonism Enhances Cellular Metabolism to Support CD8+ T-cell Proliferation and Effector Cytokine Production in a Mouse Tumor Model
- (2018) Simran S. Sabharwal et al. Cancer Immunology Research
- A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti–PD-(L)1 and Anti–CTLA-4 in Preclinical Models
- (2018) Stephen B. Willingham et al. Cancer Immunology Research
- Reinforce the antitumor activity of CD8+ T cells via glutamine restriction
- (2018) Shogo Nabe et al. CANCER SCIENCE
- Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
- (2018) Marc O. Johnson et al. CELL
- Palmitoylation stabilizes PD-L1 to promote breast tumor growth
- (2018) Yi Yang et al. CELL RESEARCH
- The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
- (2018) Shane J. F. Cronin et al. NATURE
- Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
- (2018) Toszka Bohn et al. NATURE IMMUNOLOGY
- Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation
- (2018) Paras S. Minhas et al. NATURE IMMUNOLOGY
- Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
- (2018) Danbee Ha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
- (2018) Christopher M. Rice et al. Nature Communications
- Human Dendritic Cell Subsets Undergo Distinct Metabolic Reprogramming for Immune Response
- (2018) Farhan Basit et al. Frontiers in Immunology
- Ovarian Cancer-Intrinsic Fatty Acid Synthase Prevents Anti-tumor Immunity by Disrupting Tumor-Infiltrating Dendritic Cells
- (2018) Li Jiang et al. Frontiers in Immunology
- IDO1: An important immunotherapy target in cancer treatment
- (2017) Fangxuan Li et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- New B7 Family Checkpoints in Human Cancers
- (2017) Ling Ni et al. MOLECULAR CANCER THERAPEUTICS
- Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
- (2017) Jessica B. Spinelli et al. SCIENCE
- Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
- (2017) Filippo Veglia et al. Nature Communications
- Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors
- (2017) Eva M. Palsson-McDermott et al. Frontiers in Immunology
- Arginine Metabolism in Myeloid Cells Shapes Innate and Adaptive Immunity
- (2017) Paulo C. Rodriguez et al. Frontiers in Immunology
- Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity
- (2017) Xenia Geeraerts et al. Frontiers in Immunology
- EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity
- (2017) Diana I. Albu et al. OncoImmunology
- Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment
- (2017) Susanne M. Steggerda et al. Journal for ImmunoTherapy of Cancer
- The Feasibility and Safety of Surgery in Patients Receiving Immune Checkpoint Inhibitors: A Retrospective Study
- (2017) Alexandra W. Elias et al. Frontiers in Oncology
- Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
- (2017) Seema Gupta et al. Frontiers in Oncology
- Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α
- (2016) Sangbin Lim et al. CANCER RESEARCH
- L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
- (2016) Roger Geiger et al. CELL
- AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival
- (2016) Rigel J. Kishton et al. Cell Metabolism
- 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8+ T cell proliferation
- (2016) Beom K Choi et al. Cellular & Molecular Immunology
- Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab: Single centre subset analysis from a phase 1/2 trial
- (2016) Antonin Levy et al. EUROPEAN JOURNAL OF CANCER
- mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation
- (2016) Hu Zeng et al. IMMUNITY
- Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
- (2016) Ana C. Anderson et al. IMMUNITY
- Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family
- (2016) Frank A. Schildberg et al. IMMUNITY
- T-cell metabolism governing activation, proliferation and differentiation; a modular view
- (2016) Sarah Dimeloe et al. IMMUNOLOGY
- Targeting PD-1 and Tim-3 Pathways to Reverse CD8 T-Cell Exhaustion and Enhance Ex Vivo T-Cell Responses to Autologous Dendritic/Tumor Vaccines
- (2016) Jingwei Liu et al. JOURNAL OF IMMUNOTHERAPY
- The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia
- (2016) M Qorraj et al. LEUKEMIA
- Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
- (2016) Wei Yang et al. NATURE
- Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
- (2016) M. Peng et al. SCIENCE
- COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis
- (2016) Mousumi Majumder et al. STEM CELLS
- Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
- (2016) Chia-Wei Li et al. Nature Communications
- Improved Efficacy of Neoadjuvant Compared to Adjuvant Immunotherapy to Eradicate Metastatic Disease
- (2016) J. Liu et al. Cancer Discovery
- A phase I study of indoximod in patients with advanced malignancies
- (2016) Hatem H. Soliman et al. Oncotarget
- Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia
- (2016) Nicole E. Scharping et al. Cancer Immunology Research
- Immunological Mechanisms Underneath the Efficacy of Cancer Therapy
- (2016) L. Galluzzi et al. Cancer Immunology Research
- Targeting CD73 in the tumor microenvironment with MEDI9447
- (2016) Carl M. Hay et al. OncoImmunology
- Metabolic communication in tumors: a new layer of immunoregulation for immune evasion
- (2016) Ping-Chih Ho et al. Journal for ImmunoTherapy of Cancer
- Increased expression of IDO associates with poor postoperative clinical outcome of patients with gastric adenocarcinoma
- (2016) Hao Liu et al. Scientific Reports
- Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth
- (2015) Chunming Cheng et al. CANCER CELL
- Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor- B to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer
- (2015) J. Peng et al. CANCER RESEARCH
- Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
- (2015) Shari Pilon-Thomas et al. CANCER RESEARCH
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
- (2015) Santiago Zelenay et al. CELL
- Metabolic reprogramming in macrophages and dendritic cells in innate immunity
- (2015) Beth Kelly et al. CELL RESEARCH
- Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival
- (2015) Ulf H. Beier et al. FASEB JOURNAL
- Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine
- (2015) Aiden Haghikia et al. IMMUNITY
- TIGIT and PD-1 impair tumor antigen–specific CD8+ T cells in melanoma patients
- (2015) Joe-Marc Chauvin et al. JOURNAL OF CLINICAL INVESTIGATION
- TIGIT predominantly regulates the immune response via regulatory T cells
- (2015) Sema Kurtulus et al. JOURNAL OF CLINICAL INVESTIGATION
- Costimulation Endows Immunotherapeutic CD8 T Cells with IL-36 Responsiveness during Aerobic Glycolysis
- (2015) Naomi Tsurutani et al. JOURNAL OF IMMUNOLOGY
- Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression
- (2015) Tingting Pan et al. MEDIATORS OF INFLAMMATION
- PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma
- (2015) Yiwei Wang et al. MEDICAL ONCOLOGY
- Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection
- (2015) Jonathan H Chen et al. NATURE MEDICINE
- PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
- (2015) Dung T. Le et al. NEW ENGLAND JOURNAL OF MEDICINE
- COX/mPGES-1/PGE2pathway depicts an inflammatory-dependent high-risk neuroblastoma subset
- (2015) Karin Larsson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
- (2015) Dorota Klysz et al. Science Signaling
- Targeting T cell metabolism for therapy
- (2015) David O'Sullivan et al. TRENDS IN IMMUNOLOGY
- The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity
- (2015) Duygu Sag et al. Nature Communications
- PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
- (2015) Nikolaos Patsoukis et al. Nature Communications
- Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model
- (2015) Claudia Sorrentino et al. Oncotarget
- Understanding the role of the kynurenine pathway in human breast cancer immunobiology
- (2015) Benjamin Heng et al. Oncotarget
- LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
- (2015) Ruea-Yea Huang et al. Oncotarget
- Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
- (2015) Dorota Klysz et al. Science Signaling
- Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity
- (2015) Yongkui Li et al. OncoImmunology
- Mesothelioma Tumor Cells Modulate Dendritic Cell Lipid Content, Phenotype and Function
- (2015) Joanne K. Gardner et al. PLoS One
- The Polyunsaturated Fatty Acids Arachidonic Acid and Docosahexaenoic Acid Induce Mouse Dendritic Cells Maturation but Reduce T-Cell Responses In Vitro
- (2015) Johan A. Carlsson et al. PLoS One
- Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism
- (2014) Marta Yanina Pepino et al. Annual Review of Nutrition
- The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8 + T Cell Effector Function
- (2014) Robert J. Johnston et al. CANCER CELL
- Biochemical Signaling of PD-1 on T Cells and Its Functional Implications
- (2014) Vassiliki A. Boussiotis et al. CANCER JOURNAL
- 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy
- (2014) Dongsheng Zhang et al. CANCER LETTERS
- An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer
- (2014) Song Xu et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function
- (2014) Andrew N. Macintyre et al. Cell Metabolism
- Metabolism of activated T lymphocytes
- (2014) Jason A Maciolek et al. CURRENT OPINION IN IMMUNOLOGY
- Enhanced suppressor function of TIM-3+FoxP3+regulatory T cells
- (2014) Anne-Sophie Gautron et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses
- (2014) Nicole Joller et al. IMMUNITY
- Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues
- (2014) Tetsuya Honda et al. IMMUNITY
- Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
- (2014) David O’Sullivan et al. IMMUNITY
- Metabolic Reprogramming of Macrophages
- (2014) Alex J. Freemerman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
- (2014) S. R. Jacobs et al. JOURNAL OF IMMUNOLOGY
- Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway
- (2014) H. Shime et al. JOURNAL OF IMMUNOLOGY
- Too Much of a Good Thing? Tim-3 and TCR Signaling in T Cell Exhaustion
- (2014) Robert L. Ferris et al. JOURNAL OF IMMUNOLOGY
- Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation
- (2014) Mathieu Gigoux et al. MOLECULAR IMMUNOLOGY
- Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway
- (2014) J Park et al. Mucosal Immunology
- CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
- (2014) Yu-Hwa Huang et al. NATURE
- Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion
- (2014) J. M. Marchingo et al. SCIENCE
- Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment
- (2013) F. Mussai et al. BLOOD
- Targeting glucose metabolism in patients with cancer
- (2013) Shannon E. Elf et al. CANCER
- Benefits of Vascular Normalization Are Dose and Time Dependent--Letter
- (2013) Y. Huang et al. CANCER RESEARCH
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
- (2013) Chih-Hao Chang et al. CELL
- Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
- (2013) Katrien De Bock et al. CELL
- Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer
- (2013) L Bracci et al. CELL DEATH AND DIFFERENTIATION
- Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
- (2013) B. Allard et al. CLINICAL CANCER RESEARCH
- Sustained Interactions between T Cell Receptors and Antigens Promote the Differentiation of CD4+ Memory T Cells
- (2013) Chulwoo Kim et al. IMMUNITY
- Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas
- (2013) Jing Zeng et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
- Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid
- (2013) A. Nasi et al. JOURNAL OF IMMUNOLOGY
- Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
- (2013) Z. Husain et al. JOURNAL OF IMMUNOLOGY
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
- (2013) Andrew L Doedens et al. NATURE IMMUNOLOGY
- Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
- (2013) Yoko Kidani et al. NATURE IMMUNOLOGY
- Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
- (2013) Linda V Sinclair et al. NATURE IMMUNOLOGY
- Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
- (2013) Nicola Gagliani et al. NATURE MEDICINE
- Fueling Immunity: Insights into Metabolism and Lymphocyte Function
- (2013) E. L. Pearce et al. SCIENCE
- Nitric oxide and cancer: a review
- (2013) Sheetal Korde Choudhari et al. World Journal of Surgical Oncology
- Depletion ofL-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes
- (2012) Rósula García-Navas et al. Autophagy
- Basis of CTLA-4 function in regulatory and conventional CD4+ T cells
- (2012) X. Tai et al. BLOOD
- Chemotherapy broadens the range of tumor antigens seen by cytotoxic CD8+ T cells in vivo
- (2012) Connie Jackaman et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- VEGFA-VEGFR Pathway Blockade Inhibits Tumor-Induced Regulatory T-cell Proliferation in Colorectal Cancer
- (2012) M. Terme et al. CANCER RESEARCH
- Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma
- (2012) Hang Li et al. HEPATOLOGY
- PGE2-Driven Induction and Maintenance of Cancer-Associated Myeloid-Derived Suppressor Cells
- (2012) Nataša Obermajer et al. IMMUNOLOGICAL INVESTIGATIONS
- Silencing IDO in dendritic cells: A novel approach to enhance cancer immunotherapy in a murine breast cancer model
- (2012) Xiufen Zheng et al. INTERNATIONAL JOURNAL OF CANCER
- Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury
- (2012) Li Li et al. JOURNAL OF CLINICAL INVESTIGATION
- The TIGIT/CD226 Axis Regulates Human T Cell Function
- (2012) E. Lozano et al. JOURNAL OF IMMUNOLOGY
- AMPK: a nutrient and energy sensor that maintains energy homeostasis
- (2012) D. Grahame Hardie et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma
- (2012) Michael A. Postow et al. NEW ENGLAND JOURNAL OF MEDICINE
- Indoleamine 2,3 dioxygenase and metabolic control of immune responses
- (2012) David H. Munn et al. TRENDS IN IMMUNOLOGY
- The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway
- (2012) Akio Ohta et al. Frontiers in Immunology
- Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
- (2011) Sophia Y. Lunt et al. Annual Review of Cell and Developmental Biology
- Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
- (2011) S.-R. Woo et al. CANCER RESEARCH
- Modulation of human T-cell functions by reactive nitrogen species
- (2011) Tihana Kasic et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
- Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation
- (2011) Anna N. Mendler et al. INTERNATIONAL JOURNAL OF CANCER
- HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells
- (2011) Lewis Z. Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
- (2011) D. Anastasiou et al. SCIENCE
- Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4
- (2011) O. S. Qureshi et al. SCIENCE
- IDO inhibits T-cell function through suppressing Vav1 expression and activation
- (2010) Runmei Li et al. CANCER BIOLOGY & THERAPY
- CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice
- (2010) Xiaofeng Sun et al. GASTROENTEROLOGY
- Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice
- (2010) Rupal Ramakrishnan et al. JOURNAL OF CLINICAL INVESTIGATION
- Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients
- (2010) Julien Fourcade et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
- (2010) Kaori Sakuishi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites
- (2010) C. Camisaschi et al. JOURNAL OF IMMUNOLOGY
- Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells
- (2010) V. Dardalhon et al. JOURNAL OF IMMUNOLOGY
- Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
- (2010) E. L. Carr et al. JOURNAL OF IMMUNOLOGY
- Lipid accumulation and dendritic cell dysfunction in cancer
- (2010) Donna L Herber et al. NATURE MEDICINE
- mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat
- (2009) Nattida Chotechuang et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- A Novel Cancer Therapy by Skin Delivery of Indoleamine 2,3-Dioxygenase siRNA
- (2009) M.-C. Yen et al. CLINICAL CANCER RESEARCH
- The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
- (2009) Greg M. Delgoffe et al. IMMUNITY
- PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
- (2009) Loise M. Francisco et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Anergic T Cells Are Metabolically Anergic
- (2009) Y. Zheng et al. JOURNAL OF IMMUNOLOGY
- LAG-3 Regulates Plasmacytoid Dendritic Cell Homeostasis
- (2009) C. J. Workman et al. JOURNAL OF IMMUNOLOGY
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Cellular fatty acid uptake: a pathway under construction
- (2009) Xiong Su et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
- (2008) Candace M. Cham et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- CD226 Gly307Ser association with multiple autoimmune diseases
- (2008) J P Hafler et al. GENES AND IMMUNITY
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
- The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
- (2008) Xin Yu et al. NATURE IMMUNOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started