Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

(2017) Jiyeon Kim et al.   NATURE

An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues

(2017) Jessica B. Spinelli et al.   Scientific Reports

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis

(2016) Nisebita Sahu et al.   Cell Metabolism

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

(2016) Jonathan L. Coloff et al.   Cell Metabolism

Normoxic accumulation of HIF1α is associated with glutaminolysis

(2016) Matthias Kappler et al.   Clinical Oral Investigations

Ammonia toxicity: from head to toe?

(2016) Srinivasan Dasarathy et al.   METABOLIC BRAIN DISEASE

Proteomic maps of breast cancer subtypes

(2016) Stefka Tyanova et al.   Nature Communications

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

(2015) Lingtao Jin et al.   CANCER CELL

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Proline metabolism and cancer

(2015) James M. Phang et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Refining the Ammonia Hypothesis

(2015) Elliot B. Tapper et al.   MAYO CLINIC PROCEEDINGS

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites

(2014) S. Laxman et al.   Science Signaling

The effect of pH and ADP on ammonia affinity for human glutamate dehydrogenases

(2013) Ioannis Zaganas et al.   METABOLIC BRAIN DISEASE

A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

(2013) Julie Adam et al.   Cell Reports

Ammonia toxicity to the brain

(2012) Olivier Braissant et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Ammonium metabolism in humans

(2012) Maria M. Adeva et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Methods for long-term 17β-estradiol administration to mice

(2011) E. Ingberg et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Stable Isotope-Resolved Metabolomics (SIRM) in Cancer Research with Clinical Application to NonSmall Cell Lung Cancer

(2011) Andrew N. Lane et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells

(2010) Meng Meng et al.   CELL CYCLE

Function of human Rh based on structure of RhCG at 2.1 A

(2010) F. Gruswitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy

(2010) C. H. Eng et al.   Science Signaling

Hepatic glutamate metabolism: a tale of 2 hepatocytes

(2009) Margaret E Brosnan et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Growth-limiting Intracellular Metabolites in Yeast Growing under Diverse Nutrient Limitations

(2009) Viktor M. Boer et al.   MOLECULAR BIOLOGY OF THE CELL

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Glutamine synthetase is essential for proliferation of fetal skin fibroblasts

(2008) T. Vermeulen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis

(2008) Francesca Frigerio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Ammonium-induced calcium mobilization in 1321N1 astrocytoma cells

(2007) Petra Hillmann et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY