Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy

Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate–mediated mTOR Activation and Proline Hydroxylation

(2018) Jing Ge et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

HALO-109–301: a Phase III trial of PEGPH20 (with gemcitabine and nab-paclitaxel) in hyaluronic acid-high stage IV pancreatic cancer

(2018) Gary J Doherty et al.   Future Oncology

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

(2018) Elisa Peranzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy

(2018) Neus Martinez-Bosch et al.   Cancers

We're Not “DON” Yet: Optimal Dosing and Prodrug Delivery of6-Diazo-5-oxo-L-norleucine

(2018) Kathryn M. Lemberg et al.   MOLECULAR CANCER THERAPEUTICS

Hexosamine Biosynthetic Pathway Inhibition Leads to AML Cell Differentiation and Cell Death

(2018) Abhishek Asthana et al.   MOLECULAR CANCER THERAPEUTICS

O-GlcNAcylation promotes colorectal cancer metastasis via the miR-101-O-GlcNAc/EZH2 regulatory feedback circuit

(2018) Mingzuo Jiang et al.   ONCOGENE

Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options

(2018) Derya Kabacaoglu et al.   Frontiers in Immunology

Dynamic matrisome: ECM remodeling factors licensing cancer progression and metastasis

(2018) Arseniy E. Yuzhalin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Antifibrotic Therapy Disrupts Stromal Barriers and Modulates the Immune Landscape in Pancreatic Ductal Adenocarcinoma

(2018) Kianna Y. Elahi-Gedwillo et al.   CANCER RESEARCH

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

(2018) Thomas Bertero et al.   Cell Metabolism

Chronic pancreatitis changes in high-risk individuals for pancreatic ductal adenocarcinoma

(2018) Sushrut S. Thiruvengadam et al.   GASTROINTESTINAL ENDOSCOPY

Overcoming immune evasion in pancreatic cancer: the combination matters

(2017) Patrick Michl et al.   GUT

High expression of GFAT1 predicts unfavorable prognosis in patients with hepatocellular carcinoma

(2017) Lili Li et al.   Oncotarget

A Trickster in Disguise: Hyaluronan’s Ambivalent Roles in the Matrix

(2017) Lena Bohaumilitzky et al.   Frontiers in Oncology

Glutaminases in slowly proliferating gastroenteropancreatic neuroendocrine neoplasms/tumors (GEP-NETs): Selective overexpression of mRNA coding for the KGA isoform

(2016) Monika Szeliga et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

(2016) Yaqing Zhang et al.   GUT

Hyaluronan Production Regulates Metabolic and Cancer Stem-like Properties of Breast Cancer Cells via Hexosamine Biosynthetic Pathway-coupled HIF-1 Signaling

(2016) Theerawut Chanmee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

(2016) Rana Rais et al.   JOURNAL OF MEDICINAL CHEMISTRY

O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway

(2016) C M Ferrer et al.   ONCOGENE

The M2 phenotype of tumor-associated macrophages in the stroma confers a poor prognosis in pancreatic cancer

(2016) Hai Hu et al.   TUMOR BIOLOGY

High expression of GFAT1 predicts poor prognosis in patients with pancreatic cancer

(2016) Caiting Yang et al.   Scientific Reports

Identification of Cancer-Associated Fibroblasts in Circulating Blood from Patients with Metastatic Breast Cancer

(2015) Z. Ao et al.   CANCER RESEARCH

Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer

(2015) S. Banerjee et al.   CLINICAL CANCER RESEARCH

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

Primary and Liver Metastasis–Derived Cell Lines From KrasG12D; Trp53R172H; Pdx-1 Cre Animals Undergo Apoptosis in Response to Triptolide

(2015) Veena Sangwan et al.   PANCREAS

ER stress and hexosamine pathway during tumourigenesis: A pas de deux?

(2015) Sophie Vasseur et al.   SEMINARS IN CANCER BIOLOGY

Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies

(2015) E. Gabriela Chiorean et al.   Drug Design Development and Therapy

Reviving Lonidamine and 6-Diazo-5-oxo-L-norleucine to Be Used in Combination for Metabolic Cancer Therapy

(2015) Diana Cervantes-Madrid et al.   Biomed Research International

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

The complex landscape of pancreatic cancer metabolism

(2014) C. M. Sousa et al.   CARCINOGENESIS

Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer

(2014) N. Hartmann et al.   CLINICAL CANCER RESEARCH

CD133+ Tumor Initiating Cells in a Syngenic Murine Model of Pancreatic Cancer Respond to Minnelide

(2014) S. Banerjee et al.   CLINICAL CANCER RESEARCH

Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity

(2014) Ingunn M Stromnes et al.   GUT

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in Mice

(2014) Y. Zhang et al.   Cancer Immunology Research

Impact of tumour associated macrophages in pancreatic cancer

(2013) Ainhoa Mielgo et al.   BMB Reports

Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

(2013) Y Ino et al.   BRITISH JOURNAL OF CANCER

Triptolide-induced Cell Death in Pancreatic Cancer Is Mediated byO-GlcNAc Modification of Transcription Factor Sp1

(2013) Sulagna Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic control of hyaluronan synthases

(2013) Davide Vigetti et al.   MATRIX BIOLOGY

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Isolation of Normal and Cancer-associated Fibroblasts from Fresh Tissues by Fluorescence Activated Cell Sorting (FACS)

(2013) Yoray Sharon et al.   Jove-Journal of Visualized Experiments

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Role of Chemokines and Chemokine Receptors in Shaping the Effector Phase of the Antitumor Immune Response

(2012) K. Franciszkiewicz et al.   CANCER RESEARCH

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Single-vector inducible lentiviral RNAi system for oncology target validation

(2011) Dmitri Wiederschain et al.   CELL CYCLE

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

Stromal biology and therapy in pancreatic cancer

(2010) A. Neesse et al.   GUT

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Interstitial leukocyte migration and immune function

(2008) Peter Friedl et al.   NATURE IMMUNOLOGY

PTEN-deficient cancers depend on PIK3CB

(2008) S. Wee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA