mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+Regulatory T Cells
出版年份 2018 全文链接
标题
mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+Regulatory T Cells
作者
关键词
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出版物
JOURNAL OF IMMUNOLOGY
Volume 201, Issue 2, Pages 481-492
出版商
The American Association of Immunologists
发表日期
2018-06-09
DOI
10.4049/jimmunol.1701477
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- TCR Signal Strength Regulates Akt Substrate Specificity To Induce Alternate Murine Th and T Regulatory Cell Differentiation Programs
- (2017) William F. Hawse et al. JOURNAL OF IMMUNOLOGY
- The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements
- (2016) Claudio Procaccini et al. IMMUNITY
- Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression
- (2016) Valerie A Gerriets et al. NATURE IMMUNOLOGY
- Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner
- (2016) Lianjun Zhang et al. Cell Reports
- mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
- (2015) Kristen N. Pollizzi et al. JOURNAL OF CLINICAL INVESTIGATION
- TIGIT predominantly regulates the immune response via regulatory T cells
- (2015) Sema Kurtulus et al. JOURNAL OF CLINICAL INVESTIGATION
- Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance
- (2015) Kyle Leonard O’Hagan et al. JOURNAL OF IMMUNOLOGY
- Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
- (2015) Sharad Shrestha et al. NATURE IMMUNOLOGY
- Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants
- (2015) Veronica De Rosa et al. NATURE IMMUNOLOGY
- Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
- (2015) Alexandria Huynh et al. NATURE IMMUNOLOGY
- The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells
- (2015) Ajithkumar Vasanthakumar et al. NATURE IMMUNOLOGY
- Type 1 diabetes immunotherapy using polyclonal regulatory T cells
- (2015) Jeffrey A. Bluestone et al. Science Translational Medicine
- Regulation of T cells by mTOR: the known knowns and the known unknowns
- (2015) Kristen N. Pollizzi et al. TRENDS IN IMMUNOLOGY
- Cellular Size as a Means of Tracking mTOR Activity and Cell Fate of CD4+ T Cells upon Antigen Recognition
- (2015) Kristen N. Pollizzi et al. PLoS One
- T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo
- (2014) Nicholas van Panhuys et al. IMMUNITY
- Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells
- (2014) Hiromasa Morikawa et al. IMMUNOLOGICAL REVIEWS
- Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance
- (2014) Fang Yu et al. NATURE IMMUNOLOGY
- Continuous requirement for the TCR in regulatory T cell function
- (2014) Andrew G Levine et al. NATURE IMMUNOLOGY
- mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity
- (2014) S.-C. Cheng et al. SCIENCE
- TCR signal quantity and quality in CD4+ T cell differentiation
- (2014) Noah J. Tubo et al. TRENDS IN IMMUNOLOGY
- CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets
- (2013) Kate S. Smigiel et al. JOURNAL OF EXPERIMENTAL MEDICINE
- T Cell Activation Threshold Regulated by E3 Ubiquitin Ligase Cbl-b Determines Fate of Inducible Regulatory T Cells
- (2013) G. Qiao et al. JOURNAL OF IMMUNOLOGY
- mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
- (2013) Hu Zeng et al. NATURE
- The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells
- (2013) F. Raczkowski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Duration of T Cell Stimulation Is a Critical Determinant of Cell Fate and Plasticity
- (2013) N. Miskov-Zivanov et al. Science Signaling
- Regulation of Immune Responses by mTOR
- (2012) Jonathan D. Powell et al. Annual Review of Immunology
- Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation
- (2012) Xing Chang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
- (2012) Daniela Cipolletta et al. NATURE
- Distinct Inflammatory Signals Have Physiologically Divergent Effects on Epigenetic Regulation of Foxp3 Expression and Treg Function
- (2011) G. Lal et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease
- (2011) K. L. Hippen et al. AMERICAN JOURNAL OF TRANSPLANTATION
- An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells
- (2011) Yunqi Wang et al. IMMUNITY
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
- GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
- (2011) Elizabeth A. Wohlfert et al. JOURNAL OF CLINICAL INVESTIGATION
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
- (2011) Erika Cretney et al. NATURE IMMUNOLOGY
- The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
- (2011) Greg M Delgoffe et al. NATURE IMMUNOLOGY
- Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
- (2011) Yeonseok Chung et al. NATURE MEDICINE
- Foxp3+ follicular regulatory T cells control the germinal center response
- (2011) Michelle A Linterman et al. NATURE MEDICINE
- An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness
- (2010) Claudio Procaccini et al. IMMUNITY
- TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
- (2010) Rachel A. Gottschalk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
- (2009) Greg M. Delgoffe et al. IMMUNITY
- Anergic T Cells Are Metabolically Anergic
- (2009) Y. Zheng et al. JOURNAL OF IMMUNOLOGY
- Dominant Role of Antigen Dose in CD4+Foxp3+ Regulatory T Cell Induction and Expansion
- (2009) M. S. Turner et al. JOURNAL OF IMMUNOLOGY
- mTOR regulates memory CD8 T-cell differentiation
- (2009) Koichi Araki et al. NATURE
- Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses
- (2009) Ye Zheng et al. NATURE
- The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
- (2009) Meghan A Koch et al. NATURE IMMUNOLOGY
- Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin
- (2009) Laura Strauss et al. PLoS One
- The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo
- (2008) Milica Vukmanovic-Stejic et al. JOURNAL OF CLINICAL INVESTIGATION
- The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells
- (2008) Sokol Haxhinasto et al. JOURNAL OF EXPERIMENTAL MEDICINE
- T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
- (2008) S. Sauer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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