Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

(2018) Ashley V. Menk et al.   Cell Reports

Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer

(2018) Marcus D. Goncalves et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stability and function of regulatory T cells expressing the transcription factor T-bet

(2017) Andrew G. Levine et al.   NATURE

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ

(2015) John R. Somoza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

(2015) Kristen N. Pollizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection

(2013) Myoungjoo V. Kim et al.   IMMUNITY

Differentiation of CD8 memory T cells depends on Foxo1

(2013) Rodrigo Hess Michelini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation

(2012) Rajesh R. Rao et al.   IMMUNITY

Novel Foxo1-dependent transcriptional programs control Treg cell function

(2012) Weiming Ouyang et al.   NATURE

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Foxo: in command of T lymphocyte homeostasis and tolerance

(2010) Weiming Ouyang et al.   TRENDS IN IMMUNOLOGY