Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

Adoptive cell transfer as personalized immunotherapy for human cancer

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Neoantigens in cancer immunotherapy

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T cell exclusion, immune privilege, and the tumor microenvironment

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The future of immune checkpoint therapy

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PD-1 blockade induces responses by inhibiting adaptive immune resistance

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Metabolic Regulation of T Lymphocytes

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Immune Modulation in Cancer with Antibodies

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ACAT Inhibitors: The Search for Novel Cholesterol Lowering Agents

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Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

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Advances in targeting cell surface signalling molecules for immune modulation

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Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells

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Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering

(2012) Eszter Molnár et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

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Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

Conformational states of the kinase Lck regulate clustering in early T cell signaling

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LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection

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Cancer immunotherapy comes of age

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Antigen-Induced Oligomerization of the B Cell Receptor Is an Early Target of FcγRIIB Inhibition

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Acyl-coenzyme A:cholesterol acyltransferases

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Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling

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Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory Domain

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The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

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Cholesterol Synthesis Inhibitor U18666A and the Role of Sterol Metabolism and Trafficking in Numerous Pathophysiological Processes

(2009) Richard J. Cenedella   LIPIDS

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

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Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

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ACAT as a Drug Target for Alzheimer’s Disease

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