Editorial Material
Neurosciences
Richard S. Finkel, Kenneth H. Fischbeck
Summary: Gene replacement therapies have made significant progress in the treatment of spinal muscular atrophy, but there are concerns about the potential toxic overexpression of SMN protein in diseased mice.
NATURE NEUROSCIENCE
(2021)
Editorial Material
Cell Biology
Mark W. Pataky, K. Sreekumaran Nair
Summary: Moderate aerobic exercise is beneficial for health, but excessive and high-intensity aerobic exercise may have negative effects on mitochondrial function and glucose tolerance.
Review
Endocrinology & Metabolism
Frances M. Ashcroft, Matthew Lloyd, Elizabeth A. Haythorne
Summary: Type 2 diabetes is a global health problem characterized by inadequate insulin secretion and chronic high blood sugar. While it was initially believed that drugs stimulating glucokinase would enhance insulin secretion, recent studies have shown that it is the hyperactivation of glucose metabolism, not glucose itself, that leads to the progressive decline in beta-cell function. This perspective discusses the potential exacerbation of this decline by glucokinase activators and counterintuitively proposes that glucokinase inhibitors might be a better therapeutic strategy for preserving beta-cell function in Type 2 diabetes.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Editorial Material
Biochemistry & Molecular Biology
Lea P. Wilhelm, Ian G. Ganley
Summary: Three new studies demonstrate that the disease-associated FBXL4 protein plays a crucial role in regulating constitutive mitophagy by controlling the stability of mitophagy receptors BNIP3 and NIX.
Editorial Material
Endocrinology & Metabolism
John A. Hawley, David J. Bishop
Summary: Exercise training can have positive effects on mitochondrial function and metabolic health outcomes, but there may be a limit to the amount of high-intensity training that the body can tolerate before disruptions occur.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Anthony J. Michael
Summary: Researchers identified yeast high-affinity spermidine transporter, elucidated the translational mechanism driven by mRNA uORF/eIF5a for sensing spermidine levels, and demonstrated that excess spermidine competitively inhibits eIF5a function, leading to reduced spermidine uptake.
Review
Immunology
Christo Tsilifis, Mary A. Slatter, Andrew R. Gennery
Summary: Primary immune regulatory disorders (PIRDs) are a group of inborn errors of immunity caused by defects in the regulatory mechanism of the immune response. They can lead to various diseases such as infections, autoimmunity, autoinflammation, malignancy, and allergy. Recognition and treatment of PIRDs remain challenging due to their diverse phenotype and limited data on natural history and treatment. International collaboration is needed to better understand PIRDs and develop effective therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Robert John Norman
Summary: Intracytoplasmic sperm injection (ICSI) was initially introduced for male infertility but is now widely used in assisted reproduction techniques. The indications for ICSI use need to be re-evaluated to ensure appropriate application in infertility management.
FERTILITY AND STERILITY
(2022)
Article
Cell Biology
Chen Han, May Barakat, Luisa A. DiPietro
Summary: Angiogenesis, the growth of new blood vessels, is crucial for wound repair. The restoration of normal oxygen levels is essential for proper tissue healing. However, excessive angiogenesis can lead to abnormal blood vessels. Fine-tuning capillary regrowth in wounds has significant therapeutic potential in treating poorly healing wounds.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Kevin J. Downes, Jennifer L. Goldman
Summary: Antimicrobials are a common cause of drug toxicity, and understanding the relationship between systemic antimicrobial exposure and toxicity is necessary for healthcare providers to prevent undesired drug effects. Different categories are used to classify the relationship between exposure and toxicity of antimicrobial agents, which can help minimize observed toxicities and integrate effective therapeutic drug monitoring strategies.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
John E. Cronan
Summary: FadR is a transcription factor in E. coli that regulates fatty acid metabolism in response to environmental fatty acids. It represses fatty acid degradation genes and activates fatty acid synthesis genes. Overproduction of FadR increases fatty acid yields but may have negative effects on cell physiology.
MOLECULAR MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Ornella Pagliano, Robert M. Morrison, Joe-Marc Chauvin, Hridesh Banerjee, Diwakar Davar, Quanquan Ding, Tokiyoshi Tanegashima, Wentao Gao, Saranya R. Chakka, Richelle DeBlasio, Ava Lowin, Kevin Kara, Mignane Ka, Bochra Zidi, Rada Amin, Itay Raphael, Shuowen Zhang, Simon C. Watkins, Cindy Sander, John M. Kirkwood, Marcus Bosenberg, Ana C. Anderson, Vijay K. Kuchroo, Lawrence P. Kane, Alan J. Korman, Arvind Rajpal, Sean M. West, Minhua Han, Christine Bee, Xiaodi Deng, Xiao Min Schebye, Pavel Strop, Hassane M. Zarour
Summary: Tim-3 blockade disrupts the trogocytosis of tumor-specific CD8(+) T cells and PD-1(+)Tim-3(+) CD8(+) TILs, leading to decreased tumor burden and prolonged survival in melanoma.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Business, Finance
Douglas (DJ) Fairhurst, Daniel T. Greene
Summary: This study examines the relationship between corporate social responsibility (CSR) and firm value using the takeover market as an empirical setting. The findings suggest that firms with either very high or very low CSR scores are more likely to experience takeovers with lower wealth gains, while firms with moderate CSR policies tend to have higher firm value.
JOURNAL OF CORPORATE FINANCE
(2022)
Article
Plant Sciences
Christopher J. Lortie, Mario Zuliani, Nargol Ghazian, Stephanie Haas, Jenna Braun, Malory Owen, Florencia Miguel, Merav Seifan, Alessandro Filazzola, Jacob Lucero
Summary: The study explored the complex interactions between local plant species richness and shrub facilitation intensity to maintain biodiversity in arid ecosystems. It was found that increasing local plant species richness shifted the interaction with shrubs from positive to negative, indicating that higher richness does not always enhance functions that maintain diversity in plant communities.
JOURNAL OF ECOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tixiao Wang, Jie Zhang, Na Li, Mengzhen Li, Shuaiya Ma, Siyu Tan, Xiaowei Guo, Zehua Wang, Zhuanchang Wu, Lifen Gao, Chunhong Ma, Xiaohong Liang
Summary: The spatial organization of immune cells within the tumor microenvironment (TME) plays a crucial role in anti-tumor immunity, tumor progression, and therapeutic response. Tim-3 is an immune checkpoint with potential as an immunotherapy target. This study examined the spatial distribution of Tim-3/Tim-3L in the TME and found that CD4 T cells were more accumulated in the tumor region and had a closer association with patient survival. CD4 T cells surrounding Tim-3L(+) cells expressed higher levels of Tim-3. Depletion of CD4 T cells abrogated the inhibition of tumor growth and metastasis mediated by Tim-3 blockade. These findings highlight the importance of CD4 T cells in Tim-3/Tim-3L-mediated immunosuppression and provide insights for Tim-3 targeted cancer immunotherapy.
Article
Immunology
William F. Hawse, Robert P. Sheehan, Natasa Miskov-Zivanov, Ashley V. Menk, Lawrence P. Kane, James R. Faeder, Penelope A. Morel
JOURNAL OF IMMUNOLOGY
(2015)
Article
Immunology
Binh Phong, Lyndsay Avery, Ashley V. Menk, Greg M. Delgoffe, Lawrence P. Kane
JOURNAL OF IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Lyndsay Avery, Jessica Filderman, Andrea L. Szymczak-Workman, Lawrence P. Kane
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Medicine, Research & Experimental
Jeremy S. Tilstra, Lyndsay Avery, Ashley V. Menk, Rachael A. Gordon, Shuchi Smita, Lawrence P. Kane, Maria Chikina, Greg M. Delgoffe, Mark J. Shlomchik
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Editorial Material
Immunology
Lawrence P. Kane
JOURNAL OF IMMUNOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Kristia S. Hamilton, Binh Phong, Catherine Corey, Jing Cheng, Balachandra Gorentla, Xiaoping Zhong, Sruti Shiva, Lawrence P. Kane
Article
Immunology
Uzodinma U. Uche, Ann R. Piccirillo, Shunsuke Kataoka, Stephanie J. Grebinoski, Louise M. D'Cruz, Lawrence P. Kane
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Immunology
Gerard Hernandez-Mir, Itay Raphael, Shankar Revu, Catherine H. Poholek, Lyndsay Avery, William F. Hawse, Lawrence P. Kane, Mandy J. McGeachy
JOURNAL OF IMMUNOLOGY
(2019)
Article
Virology
Kate L. Carroll, Lyndsay Avery, Benjamin R. Treat, Lawrence P. Kane, Paul R. Kinchington, Robert L. Hendricks, Anthony J. St Leger
JOURNAL OF VIROLOGY
(2020)
Article
Immunology
Catherine H. Poholek, Itay Raphael, Dongwen Wu, Shankar Revu, Natalie Rittenhouse, Uzodinma U. Uche, Saikat Majumder, Lawrence P. Kane, Amanda C. Poholek, Mandy J. McGeachy
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Immunology
Kristina Ottens, Jalyn Schneider, Lawrence P. Kane, Anne B. Satterthwaite
JOURNAL OF IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Shunsuke Kataoka, Priyanka Manandhar, Judong Lee, Creg J. Workman, Hridesh Banerjee, Andrea L. Szymczak-Workman, Michael Kvorjak, Jason Lohmueller, Lawrence P. Kane
Summary: Tim-3, a transmembrane protein, is known to have inhibitory functions but can also exhibit paradoxical costimulatory activity in T cells under certain circumstances; The recruitment of Tim-3 to the immune synapse is mediated exclusively by its transmembrane domain, which plays a crucial role in its function in T cells; Under acute conditions, it is possible that Tim-3 enhances TCR signaling.
Editorial Material
Biochemistry & Molecular Biology
Lawrence P. Kane
Summary: Tim-3 is a transmembrane protein that is highly expressed on subsets of chronically stimulated CD4+ helper and CD8+ cytotoxic T cells, with more transient expression during acute activation and infection. Lemmon and colleagues demonstrate for the first time that recognition of phosphatidyl-serine by Tim-3 leads to enhanced T cell activation.
BIOCHEMICAL JOURNAL
(2021)
Article
Hematology
Emily Landy, Jemy Varghese, Vinh Dang, Andrea Szymczak-Workman, Lawrence P. Kane, Scott W. Canna
Summary: Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening hyperinflammatory syndromes. Understanding the synergistic effect of susceptibility factors can reveal key pathomechanisms in the activation of CD8 T cells.
Article
Immunology
Akash H. Verma, Jonathan P. Richardson, Chunsheng Zhou, Bianca M. Coleman, David L. Moyes, Jemima Ho, Anna R. Huppler, Kritika Ramani, Mandy J. McGeachy, Ilgiz A. Mufazalov, Ari Waisman, Lawrence P. Kane, Partha S. Biswas, Bernhard Hube, Julian R. Naglik, Sarah L. Gaffen
SCIENCE IMMUNOLOGY
(2017)