Inhibition of LDH-A by Oxamate Enhances the Efficacy of Anti-PD-1 Treatment in an NSCLC Humanized Mouse Model

Establishment and characterization of patient-derived xenografts for hormone-naïve and castrate-resistant prostate cancers to improve treatment modality evaluation

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Therapy for Stage IV Non–Small-Cell Lung Cancer Without Driver Alterations: ASCO and OH (CCO) Joint Guideline Update

(2020) Nasser H. Hanna et al.   JOURNAL OF CLINICAL ONCOLOGY

Why Warburg Works: Lactate Controls Immune Evasion through GPR81

(2020) Kathrine Lundø et al.   Cell Metabolism

Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

(2020) Khalid AbdulJabbar et al.   NATURE MEDICINE

Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

(2020) Lorenzo Galluzzi et al.   Nature Reviews Clinical Oncology

An update on the immune landscape in lung and head and neck cancers

(2020) Jennifer W. Carlisle et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

(2019) A. Flores et al.   Nature Communications

Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma

(2019) Saeed Daneshmandi et al.   Cancers

Lactate secreted by cervical cancer cells modulates macrophage phenotype

(2019) Simone Cardozo Stone et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice

(2019) Aris A. Polyzos et al.   Cell Metabolism

Cancer treatment and survivorship statistics, 2019

(2019) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses

(2019) Ismail M. Meraz et al.   Cancer Immunology Research

Immune cell PD-L1 co-localizes with macrophages and is associated with outcome in PD-1 pathway blockade therapy

(2019) Yuting Liu et al.   CLINICAL CANCER RESEARCH

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

(2019) Kathrin Renner et al.   Cell Reports

Microbial carcinogenesis: Lactic acid bacteria in gastric cancer

(2019) Karla Vinasco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Drug repurposing for anticancer therapies. A lesson from proton pump inhibitors

(2019) Enrico Pierluigi Spugnini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Targeting uptake transporters for cancer imaging and treatment

(2019) Yuchen Zhang et al.   Acta Pharmaceutica Sinica B

Metabolic reprogramming enables hepatocarcinoma cells to efficiently adapt and survive to a nutrient-restricted microenvironment

(2018) Shamir Cassim et al.   CELL CYCLE

Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate CancerIn VivoPredicts Efficacy of Targeting the Warburg Effect

(2018) Bradley T. Scroggins et al.   CLINICAL CANCER RESEARCH

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Humanized Mice for the Study of Immuno-Oncology

(2018) Philippe De La Rochere et al.   TRENDS IN IMMUNOLOGY

Revisiting the Warburg Effect: Some Tumors Hold Their Breath

(2018) Sydney M. Sanderson et al.   Cell Metabolism

Establishment of peripheral blood mononuclear cell-derived humanized lung cancer mouse models for studying efficacy of PD-L1/PD-1 targeted immunotherapy

(2018) Shouheng Lin et al.   mAbs

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway

(2016) Jing Liu et al.   Journal of Hematology & Oncology

Lactate metabolism is associated with mammalian mitochondria

(2016) Ying-Jr Chen et al.   Nature Chemical Biology

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Effect of Modified Alkaline Supplementation on Syngenic Melanoma Growth in CB57/BL Mice

(2016) Tommaso Azzarito et al.   PLoS One

Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt–mTOR signaling pathway

(2015) Zhi Zhao et al.   CANCER LETTERS

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer

(2014) Kirsten Lindner et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Effects of the suppression of lactate dehydrogenase A on the growth and invasion of human gastric cancer cells

(2014) XIAOJUN LIU et al.   ONCOLOGY REPORTS

Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells

(2013) XIAOMING ZHAI et al.   ONCOLOGY REPORTS