CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages

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CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

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CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

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Cholesterol induces T cell exhaustion

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Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes

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The Role of Sirtuins in Antioxidant and Redox Signaling

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T Cell Dysfunction in Cancer

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The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates

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Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-tolerance

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Cholesterol negatively regulates IL-9–producing CD8+T cell differentiation and antitumor activity

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Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

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Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins

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Principles of adoptive T cell therapy in cancer

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Reversing T-cell Dysfunction and Exhaustion in Cancer

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Spontaneous onset and transplant models of the Vk*MYC mouse show immunological sequelae comparable to human multiple myeloma

(2016) Rachel E. Cooke et al.   Journal of Translational Medicine

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Emerging concepts of T cell metabolism as a target of immunotherapy

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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

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Metabolic pathways in T cell activation and lineage differentiation

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Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis

(2016) Daniel Zysset et al.   Nature Communications

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

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T cell exclusion, immune privilege, and the tumor microenvironment

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Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism

(2014) Marta Yanina Pepino et al.   Annual Review of Nutrition

Regulation of Ferroptotic Cancer Cell Death by GPX4

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Selection of an Antibody Library Identifies a Pathway to Induce Immunity by Targeting CD36 on Steady-State CD8 + Dendritic Cells

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PD-1 blockade induces responses by inhibiting adaptive immune resistance

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Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

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Innate and adaptive immune cells in the tumor microenvironment

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Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

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Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study

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CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

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