Targeting CD73 in the tumor microenvironment with MEDI9447

Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action

(2016) James C. Geoghegan et al.   mAbs

Classifying Cancers Based on T-cell Infiltration and PD-L1

(2015) Michele W.L. Teng et al.   CANCER RESEARCH

Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression

(2015) Paul A Beavis et al.   Immunotherapy

Unconventional, adenosine-producing suppressor T cells induced by dendritic cells exposed to BPZE1 pertussis vaccine

(2015) G. Fedele et al.   JOURNAL OF LEUKOCYTE BIOLOGY

On being less tolerant: Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation

(2015) Alexander M. Lesokhin et al.   Science Translational Medicine

Adenosine Receptor 2A Blockade Increases the Efficacy of Anti–PD-1 through Enhanced Antitumor T-cell Responses

(2015) Paul A. Beavis et al.   Cancer Immunology Research

Melanoma Induces, and Adenosine Suppresses, CXCR3-Cognate Chemokine Production and T-cell Infiltration of Lungs Bearing Metastatic-like Disease

(2015) E. Clancy-Thompson et al.   Cancer Immunology Research

Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors

(2015) Michael Platten et al.   Frontiers in Immunology

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy

(2015) Robert D. Leone et al.   Computational and Structural Biotechnology Journal

Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

Immunoregulatory activity of adenosine and its role in human cancer progression

(2014) Sylvia Muller-Haegele et al.   Expert Review of Clinical Immunology

CD73 Participates in Cellular Multiresistance Program and Protects against TRAIL-Induced Apoptosis

(2014) A. Mikhailov et al.   JOURNAL OF IMMUNOLOGY

Breaking immunotolerance of tumors: A new perspective for dendritic cell therapy

(2014) Jacek Rolinski et al.   Journal of Immunotoxicology

Involvement of the P2X7 Purinergic Receptor in Colonic Motor Dysfunction Associated with Bowel Inflammation in Rats

(2014) Luca Antonioli et al.   PLoS One

Targeting Cancer-Derived Adenosine:New Therapeutic Approaches

(2014) A. Young et al.   Cancer Discovery

Adenosine production by human B cells and B cell-mediated suppression of activated T cells

(2013) Z. Saze et al.   BLOOD

Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

(2013) B. Allard et al.   CLINICAL CANCER RESEARCH

Agonistic CD40 Antibodies and Cancer Therapy

(2013) R. H. Vonderheide et al.   CLINICAL CANCER RESEARCH

The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy

(2013) Amy E Moran et al.   CURRENT OPINION IN IMMUNOLOGY

Anti-CD73 therapy impairs tumor angiogenesis

(2013) Bertrand Allard et al.   INTERNATIONAL JOURNAL OF CANCER

Anti-Human CD73 Monoclonal Antibody Inhibits Metastasis Formation in Human Breast Cancer by Inducing Clustering and Internalization of CD73 Expressed on the Surface of Cancer Cells

(2013) M. G. Terp et al.   JOURNAL OF IMMUNOLOGY

Combining phenotypic and proteomic approaches to identify membrane targets in a ‘triple negative’ breast cancer cell type

(2013) Steven Rust et al.   Molecular Cancer

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Beyond the Antigen Receptor: Editing the Genome of T-Cells for Cancer Adoptive Cellular Therapies

(2013) Angharad Lloyd et al.   Frontiers in Immunology

Regulation of Lymphocyte Function by Adenosine

(2012) Joel Linden et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD73-Deficient Mice Are Resistant to Carcinogenesis

(2012) J. Stagg et al.   CANCER RESEARCH

Inhibition of CD73 Improves B Cell-Mediated Anti-Tumor Immunity in a Mouse Model of Melanoma

(2012) G. Forte et al.   JOURNAL OF IMMUNOLOGY

Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor

(2011) Adam T. Waickman et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells

(2011) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression

(2010) D. Jin et al.   CANCER RESEARCH

Structural characterization of a human Fc fragment engineered for lack of effector functions

(2008) Vaheh Oganesyan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

VAP-1 and CD73, Endothelial Cell Surface Enzymes in Leukocyte Extravasation

(2007) Sirpa Jalkanen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY