标题
Ion channels as therapeutic antibody targets
作者
关键词
-
出版物
mAbs
Volume -, Issue -, Pages 1-32
出版商
Informa UK Limited
发表日期
2018-12-10
DOI
10.1080/19420862.2018.1548232
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A novel PADRE-Kv1.3 vaccine effectively induces therapeutic antibodies and ameliorates experimental autoimmune encephalomyelitis in rats
- (2018) Cheng Fan et al. CLINICAL IMMUNOLOGY
- Modulating ion channel function with antibodies and nanobodies
- (2018) Catelijne Stortelers et al. CURRENT OPINION IN IMMUNOLOGY
- Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis
- (2018) B. M. Fonseca et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Unexplored therapeutic opportunities in the human genome
- (2018) Tudor I. Oprea et al. NATURE REVIEWS DRUG DISCOVERY
- Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing
- (2018) Trisha A. Rettig et al. PLoS One
- Capsaicin inhibits the metastasis of human papillary thyroid carcinoma BCPAP cells through the modulation of the TRPV1 channel
- (2018) Shichen Xu et al. Food & Function
- Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7
- (2018) Sangsu Bang et al. Neuroscience Bulletin
- Gating mechanisms of acid-sensing ion channels
- (2018) Nate Yoder et al. NATURE
- Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death
- (2018) Min Qiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exacerbating effects of PM2.5 in OVA-sensitized and challenged mice and the expression of TRPA1 and TRPV1 proteins in lungs
- (2017) Hong Liu et al. JOURNAL OF ASTHMA
- Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus
- (2017) Isabella Derler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular, biophysical, and pharmacological properties of calcium-activated chloride channels
- (2017) Mohammad Amin Kamaleddin JOURNAL OF CELLULAR PHYSIOLOGY
- Detection of potassium channel KIR4.1 antibodies in Multiple Sclerosis patients
- (2017) Fabiana Marnetto et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Cytotoxic effect of TDZ on human cervical cancer cells
- (2017) Gansukh Enkhtaivan et al. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
- Rare, high-affinity anti-pathogen antibodies from human repertoires, discovered using microfluidics and molecular genomics
- (2017) Adam S. Adler et al. mAbs
- APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1
- (2017) Lien Moreels et al. Marine Drugs
- Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
- (2017) Qingfeng Chen et al. NATURE
- Opportunities for therapeutic antibodies directed at G-protein-coupled receptors
- (2017) Catherine J. Hutchings et al. NATURE REVIEWS DRUG DISCOVERY
- Effect of artemisinin on neuropathic pain mediated by P2X 4 receptor in dorsal root ganglia
- (2017) Mofeng Ying et al. NEUROCHEMISTRY INTERNATIONAL
- The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis
- (2017) M Gueguinou et al. ONCOGENE
- Development of therapeutic antibodies to G protein-coupled receptors and ion channels: Opportunities, challenges and their therapeutic potential in respiratory diseases
- (2017) Julie A. Douthwaite et al. PHARMACOLOGY & THERAPEUTICS
- Na V 1.7 as a pain target – From gene to pharmacology
- (2017) Irina Vetter et al. PHARMACOLOGY & THERAPEUTICS
- The druggable genome and support for target identification and validation in drug development
- (2017) Chris Finan et al. Science Translational Medicine
- Diversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformatics
- (2017) Michel Degueldre et al. TOXICON
- Thioridazine has potent antitumor effects on lung cancer stem-like cells
- (2017) Jiani Shen et al. Oncology Letters
- Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a
- (2017) Jennifer R. Deuis et al. Scientific Reports
- IgG Fc engineering to modulate antibody effector functions
- (2017) Xinhua Wang et al. Protein & Cell
- Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology
- (2017) Erik Henrich et al. eLife
- The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel
- (2017) Lenka Marsakova et al. Frontiers in Molecular Neuroscience
- Blockade of P2X4 Receptors Inhibits Neuropathic Pain-Related Behavior by Preventing MMP-9 Activation and, Consequently, Pronociceptive Interleukin Release in a Rat Model
- (2017) Agnieszka M. Jurga et al. Frontiers in Pharmacology
- T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers
- (2017) Wai-Ping Fung-Leung et al. PLoS One
- Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial
- (2017) Eric J. Tarcha et al. PLoS One
- Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease
- (2017) Tanima Bose et al. Scientific Reports
- High-yield production of “difficult-to-express” proteins in a continuous exchange cell-free system based on CHO cell lysates
- (2017) Lena Thoring et al. Scientific Reports
- STIM and ORAI proteins: crucial roles in hallmarks of cancer
- (2016) A. Fiorio Pla et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis?
- (2016) Daniel Aeschlimann et al. AMINO ACIDS
- Discovery of functional monoclonal antibodies targeting G-protein-coupled receptors and ion channels
- (2016) T. C. I. Wilkinson BIOCHEMICAL SOCIETY TRANSACTIONS
- Combining in Vitro Folding with Cell Free Protein Synthesis for Membrane Protein Expression
- (2016) Paul J. Focke et al. BIOCHEMISTRY
- STIM and calcium channel complexes in cancer
- (2016) Isaac Jardin et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Pharmacological targeting of ion channels for cancer therapy: In vivo evidences
- (2016) Luigi Leanza et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Solution-Based Single-Molecule FRET Studies of K + Channel Gating in a Lipid Bilayer
- (2016) Emma E. Sadler et al. BIOPHYSICAL JOURNAL
- The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer
- (2016) Elena Pera et al. Cancer Cell International
- TRPC3-mediated Ca2+ entry contributes to mouse airway smooth muscle cell proliferation induced by lipopolysaccharide
- (2016) Xiao-Xu Chen et al. CELL CALCIUM
- Periodic expression of Kv10.1 driven by pRb/E2F1 contributes to G2/M progression of cancer and non-transformed cells
- (2016) Diana Urrego et al. CELL CYCLE
- hERG Channels: From Antitargets to Novel Targets for Cancer Therapy
- (2016) Annarosa Arcangeli et al. CLINICAL CANCER RESEARCH
- Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines
- (2016) Ebru Aydar et al. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- In vivo imaging of tumour xenografts with an antibody targeting the potassium channel Kv10.1
- (2016) Joanna Napp et al. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- Guiding TRAIL to cancer cells through Kv10.1 potassium channel overcomes resistance to doxorubicin
- (2016) Franziska Hartung et al. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief
- (2016) Edward C Emery et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Potassium Channelopathies and Gastrointestinal Ulceration
- (2016) Jaeyong Han et al. Gut and Liver
- Overexpression of TRPV3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
- (2016) Xiaolei Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies
- (2016) Jolanda Spadavecchia et al. International Journal of Nanomedicine
- Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype
- (2016) Ameet A. Chimote et al. JOURNAL OF AUTOIMMUNITY
- Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies
- (2016) Anatoly Shcherbatko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sigma1 receptors inhibit store-operated Ca 2+ entry by attenuating coupling of STIM1 to Orai1
- (2016) Shyam Srivats et al. JOURNAL OF CELL BIOLOGY
- Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore
- (2016) Mastura Monif et al. Journal of Neuroinflammation
- Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension
- (2016) Inés Álvarez-Miguel et al. JOURNAL OF PHYSIOLOGY-LONDON
- Activation of K+channel by 1-EBIO rescues the head and neck squamous cell carcinoma cells from Ca2+ionophore-induced cell death
- (2016) Ming Zhe Yin et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- T-Type Ca2+ Channel Inhibition Sensitizes Ovarian Cancer to Carboplatin
- (2016) B. Dziegielewska et al. MOLECULAR CANCER THERAPEUTICS
- Channelling potassium to fight cancer
- (2016) K. George Chandy et al. NATURE
- TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
- (2016) Yuan Gao et al. NATURE
- A comprehensive map of molecular drug targets
- (2016) Rita Santos et al. NATURE REVIEWS DRUG DISCOVERY
- Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators
- (2016) Xin Huang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Nanodiscs for structural and functional studies of membrane proteins
- (2016) Ilia G Denisov et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Medicinal chemistry of adenosine, P2Y and P2X receptors
- (2016) Kenneth A. Jacobson et al. NEUROPHARMACOLOGY
- Kv10.1 K+ channel: from physiology to cancer
- (2016) Halima Ouadid-Ahidouch et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Modulation of the voltage-gated potassium channel Kv2.1 by the anti-tumor alkylphospholipid perifosine
- (2016) Mayra Delgado-Ramírez et al. Pharmacological Reports
- Cell-Free Systems Based on CHO Cell Lysates: Optimization Strategies, Synthesis of “Difficult-to-Express” Proteins and Future Perspectives
- (2016) Lena Thoring et al. PLoS One
- Generation of Recombinant Monoclonal Antibodies from Immunised Mice and Rabbits via Flow Cytometry and Sorting of Antigen-Specific IgG+ Memory B Cells
- (2016) Dale. O Starkie et al. PLoS One
- Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant
- (2016) Rongsheng E. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Schmerz und Schmerzlosigkeit
- (2016) M. J. Eberhardt et al. SCHMERZ
- Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology
- (2016) Amy K. LeBlanc et al. Science Translational Medicine
- KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages
- (2016) A Grimaldi et al. Cell Death & Disease
- A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis
- (2016) Han Sun et al. Nature Communications
- Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators
- (2016) Xin Huang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Nanodiscs for structural and functional studies of membrane proteins
- (2016) Ilia G Denisov et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion
- (2016) Li-Li Yang et al. Oncotarget
- Functional cooperation between KCa3.1 and TRPC1 channels in human breast cancer: Role in cell proliferation and patient prognosis
- (2016) Malika Faouzi et al. Oncotarget
- KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment
- (2016) Giuseppina D'Alessandro et al. Oncotarget
- LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia
- (2016) Shuangmei Liu et al. Molecular Brain
- High-density Lipoproteins and Apolipoprotein A-I: Potential New Players in the Prevention and Treatment of Lung Disease
- (2016) Elizabeth M. Gordon et al. Frontiers in Pharmacology
- TRP channels: potential drug target for neuropathic pain
- (2016) Lovish Marwaha et al. INFLAMMOPHARMACOLOGY
- Purinergic signaling in infection and autoimmune disease
- (2016) Luiz Eduardo Baggio Savio et al. Biomedical Journal
- Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release
- (2016) Aristos J. Alexandrou et al. PLoS One
- TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways
- (2016) Hitesh Soni et al. Scientific Reports
- High throughput screening technologies for ion channels
- (2015) Hai-bo Yu et al. ACTA PHARMACOLOGICA SINICA
- Inhibition of Transient Receptor Potential Melastain 7 Enhances Apoptosis Induced by TRAIL in PC-3 cells
- (2015) Chang-Ming Lin et al. Asian Pacific Journal of Cancer Prevention
- Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors
- (2015) Nelli Mnatsakanyan et al. BIOCHEMISTRY
- Different applications of virus-like particles in biology and medicine: Vaccination and delivery systems
- (2015) Zeinab Shirbaghaee et al. BIOPOLYMERS
- Knowledge and attitudes regarding medical research studies among patients with breast cancer and gynecological diseases
- (2015) Michael P. Lux et al. BMC CANCER
- The expression of P2X7receptors in EPCs and their potential role in the targeting of EPCs to brain gliomas
- (2015) Jingqin Fang et al. CANCER BIOLOGY & THERAPY
- SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness
- (2015) D. Crottes et al. CANCER RESEARCH
- Voltage gated sodium channels as drug discovery targets
- (2015) Sharan K Bagal et al. Channels
- Novel perspectives in cancer therapy: Targeting ion channels
- (2015) Annarosa Arcangeli et al. DRUG RESISTANCE UPDATES
- Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models
- (2015) Li Wen et al. GASTROENTEROLOGY
- Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells
- (2015) FATIMA H. MOHAMMED et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Ca2+Signaling but Not Store-Operated Ca2+Entry Is Required for the Function of Macrophages and Dendritic Cells
- (2015) Martin Vaeth et al. JOURNAL OF IMMUNOLOGY
- Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages
- (2015) Maria Barberá-Cremades et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Bacterial Voltage-Gated Sodium Channels (BacNaVs) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart
- (2015) Jian Payandeh et al. JOURNAL OF MOLECULAR BIOLOGY
- From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function
- (2015) Jeet Kalia et al. JOURNAL OF MOLECULAR BIOLOGY
- The role of ion channels in malignant brain tumors
- (2015) Ole J. Simon et al. JOURNAL OF NEURO-ONCOLOGY
- Structure and gating of CLC channels and exchangers
- (2015) Alessio Accardi JOURNAL OF PHYSIOLOGY-LONDON
- P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study
- (2015) Rayid Abdulqawi et al. LANCET
- Xyloketal B Suppresses Glioblastoma Cell Proliferation and Migration in Vitro through Inhibiting TRPM7-Regulated PI3K/Akt and MEK/ERK Signaling Pathways
- (2015) Wen-Liang Chen et al. Marine Drugs
- Activation of calcium-sensing receptor increases TRPC3/6 expression in T lymphocyte in sepsis
- (2015) Qiu-yue Wu et al. MOLECULAR IMMUNOLOGY
- Structure of the TRPA1 ion channel suggests regulatory mechanisms
- (2015) Candice E. Paulsen et al. NATURE
- EAG2 potassium channel with evolutionarily conserved function as a brain tumor target
- (2015) Xi Huang et al. NATURE NEUROSCIENCE
- AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia
- (2015) Sonya G. Lehto et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- TRPA1 as a drug target—promise and challenges
- (2015) Jun Chen et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Regulation of breast tumorigenesis through acid sensors
- (2015) S C Gupta et al. ONCOGENE
- The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma
- (2015) F Amoroso et al. ONCOGENE
- Olmsted syndrome: clinical, molecular and therapeutic aspects
- (2015) Sabine Duchatelet et al. Orphanet Journal of Rare Diseases
- The Pluto system: Initial results from its exploration by New Horizons
- (2015) S. A. Stern et al. SCIENCE
- Cancer as a channelopathy: ion channels and pumps in tumor development and progression
- (2015) Alisa Litan et al. Frontiers in Cellular Neuroscience
- Role of ion channels in regulating Ca2+ homeostasis during the interplay between immune and cancer cells
- (2015) T Bose et al. Cell Death & Disease
- Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion
- (2015) Wen-Liang Chen et al. Oncotarget
- Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo
- (2015) Michaela Nelson et al. Oncotarget
- TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells
- (2015) Swapna Asuthkar et al. Oncotarget
- Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death
- (2015) Dobrin Draganov et al. Scientific Reports
- CLCA1 and TMEM16A: the link towards a potential cure for airway diseases
- (2015) Tom J Brett Expert Review of Respiratory Medicine
- Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion
- (2015) Nelson Yee Cancers
- Voltage-Gated Ion Channels in Cancer Cell Proliferation
- (2015) Vidhya Rao et al. Cancers
- Efficacy and Safety of PPC-5650 on Experimental Rectal Pain in Patients with Irritable Bowel Syndrome
- (2014) Lecia Møller Nielsen et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief
- (2014) Jun-Ho Lee et al. CELL
- TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways
- (2014) Mingli Liu et al. CELLULAR SIGNALLING
- Axonal dysfunction with voltage gated potassium channel complex antibodies
- (2014) Susanna B. Park et al. EXPERIMENTAL NEUROLOGY
- A proinvasive role for the Ca2+-activated K+channel KCa3.1 in malignant glioma
- (2014) Kathryn L. Turner et al. GLIA
- The TRPM8 Protein Is a Testosterone Receptor
- (2014) Swapna Asuthkar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting potassium channels in cancer
- (2014) Xi Huang et al. JOURNAL OF CELL BIOLOGY
- Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade
- (2014) E M Grössinger et al. LEUKEMIA
- Differential expression of hERG1A and hERG1B genes in pediatric acute lymphoblastic leukemia identifies different prognostic subgroups
- (2014) S Pillozzi et al. LEUKEMIA
- Generation of potent mouse monoclonal antibodies to self-proteins using T-cell epitope “tags”
- (2014) Jennifer L Percival-Alwyn et al. mAbs
- Acid-sensing cation channels: Structure, function, and pathophysiologic implications
- (2014) E. E. Benarroch NEUROLOGY
- Ion channels and apoptosis in cancer
- (2014) C. D. Bortner et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma
- (2014) Anna Lisa Giuliani et al. PLoS One
- TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival
- (2014) Maylis Raphaël et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+channel: The power of native nanodiscs
- (2014) Jonas M. Dörr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Randomized clinical trial: efficacy and safety of PPC-5650 on experimental esophageal pain and hyperalgesia in healthy volunteers
- (2014) Anne Estrup Olesen et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Pharmacodynamics of TRPV1 Agonists in a Bioassay Using Human PC-3 Cells
- (2014) Daniel Alvarez-Berdugo et al. TheScientificWorldJOURNAL
- ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment
- (2014) G Bianchi et al. Cell Death & Disease
- Bladder Cancer and Urothelial Impairment: The Role of TRPV1 as Potential Drug Target
- (2014) Francesco Mistretta et al. Biomed Research International
- Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking
- (2014) João Conniot et al. Frontiers in Chemistry
- Antibody therapeutics targeting ion channels: are we there yet?
- (2013) Han Sun et al. ACTA PHARMACOLOGICA SINICA
- Pivotal Role of the Lipid Raft SK3-Orai1 Complex in Human Cancer Cell Migration and Bone Metastases
- (2013) A. Chantome et al. CANCER RESEARCH
- Single-cell based high-throughput sequencing of full-length immunoglobulin heavy and light chain genes
- (2013) Christian E. Busse et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Targeting TRP channels for pain relief
- (2013) Jill-Desiree Brederson et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice
- (2013) Roser Ufartes et al. HUMAN MOLECULAR GENETICS
- P2X7R suppression promotes glioma growth through epidermal growth factor receptor signal pathway
- (2013) Jingqin Fang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Functional expression of the voltage-gated Na+-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells
- (2013) T. M. Campbell et al. JOURNAL OF CELL SCIENCE
- Development of novel anti-Kv 11.1 antibody-conjugated PEG–TiO2 nanoparticles for targeting pancreatic ductal adenocarcinoma cells
- (2013) Angelica Sette et al. JOURNAL OF NANOPARTICLE RESEARCH
- Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors
- (2013) Aswini Gnanasekaran et al. JOURNAL OF NEUROCHEMISTRY
- Structural basis for Ca2+ selectivity of a voltage-gated calcium channel
- (2013) Lin Tang et al. NATURE
- Cancer-induced bone pain: Mechanisms and models
- (2013) A.N. Lozano-Ondoua et al. NEUROSCIENCE LETTERS
- Antibody-Mediated Targeting of the Orai1 Calcium Channel Inhibits T Cell Function
- (2013) Jennifer H. Cox et al. PLoS One
- Regulation of STIM1/Orai1-dependent Ca2+ signalling in platelets
- (2013) Patrick Münzer et al. THROMBOSIS AND HAEMOSTASIS
- P2X4 receptors and neuropathic pain
- (2013) Makoto Tsuda et al. Frontiers in Cellular Neuroscience
- Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium channels participates in prostate cancer cell growth
- (2013) Florian Gackière et al. Biology Open
- The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer
- (2013) Núria Comes et al. Frontiers in Physiology
- Structure and activity of the acid-sensing ion channels
- (2012) Thomas W. Sherwood et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Acid-sensing ion channel 1: A novel therapeutic target for migraine with aura
- (2012) Philip R. Holland et al. ANNALS OF NEUROLOGY
- Developments in autoimmune channelopathies
- (2012) Angela Vincent AUTOIMMUNITY REVIEWS
- Microchip capillary gel electrophoresis of multiply PEGylated high-molecular-mass glycoproteins
- (2012) Birgit K. Seyfried et al. Biotechnology Journal
- Expression of P2X7 Receptor Increases In Vivo Tumor Growth
- (2012) E. Adinolfi et al. CANCER RESEARCH
- Regulation of P2X3 Receptor Structure and Function
- (2012) Elsa Fabbretti et al. CNS & Neurological Disorders-Drug Targets
- Ion channel drug discovery: challenges and future directions
- (2012) A Wickenden et al. Future Medicinal Chemistry
- Innovative DNA Vaccine to Break Immune Tolerance Against Tumor Self-Antigen
- (2012) Tae Heung Kang et al. HUMAN GENE THERAPY
- T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells
- (2012) Tsuyako Ohkubo INTERNATIONAL JOURNAL OF ONCOLOGY
- Carbon Monoxide Mediates the Anti-apoptotic Effects of Heme Oxygenase-1 in Medulloblastoma DAOY Cells via K+Channel Inhibition
- (2012) Moza M. A. Al-Owais et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human ether à-gogo K+ channel 1 (hEag1) regulates MDA-MB-231 breast cancer cell migration through Orai1-dependent calcium entry
- (2012) Mehdi Hammadi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Ion Channels as Therapeutic Targets: A Drug Discovery Perspective
- (2012) Sharan K. Bagal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Frequent aberrant expression of the human ether à go-go (hEAG1) potassium channel in head and neck cancer: pathobiological mechanisms and clinical implications
- (2012) Sofía Tirados Menéndez et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity
- (2012) Patrick J. Shaw et al. JOURNAL OF PHYSIOLOGY-LONDON
- Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1
- (2012) Kristin Stock et al. NATURE MEDICINE
- Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis
- (2012) Rajneesh Srivastava et al. NEW ENGLAND JOURNAL OF MEDICINE
- Menthol Inhibits the Proliferation and Motility of Prostate Cancer DU145 Cells
- (2012) Yongzhi Wang et al. PATHOLOGY & ONCOLOGY RESEARCH
- Eag1 Channels as Potential Cancer Biomarkers
- (2012) Jesús Adrián Rodríguez-Rasgado et al. SENSORS
- TRP channels: diagnostic markers and therapeutic targets for breast cancer?
- (2012) Halima Ouadid-Ahidouch et al. TRENDS IN MOLECULAR MEDICINE
- TRP Channels and Cancer: New Targets for Diagnosis and Chemotherapy
- (2012) Giorgio Santoni et al. Endocrine Metabolic & Immune Disorders-Drug Targets
- TRP channels in prostate cancer: the good, the bad and the ugly?
- (2011) Dimitra Gkika et al. ASIAN JOURNAL OF ANDROLOGY
- Human ether-à-go-go gene potassium channels are regulated by EGFR tyrosine kinase
- (2011) Wei Wu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Senicapoc trial results support the existence of different sub-phenotypes of sickle cell disease with possible drug-induced phenotypic shifts
- (2011) Oswaldo L. Castro et al. BRITISH JOURNAL OF HAEMATOLOGY
- Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapo
- (2011) Kenneth I. Ataga et al. BRITISH JOURNAL OF HAEMATOLOGY
- Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma
- (2011) Nelson S. Yee et al. CANCER LETTERS
- Thermo-sensitive transient receptor potential vanilloid channel-1 regulates intracellular calcium and triggers chromogranin A secretion in pancreatic neuroendocrine BON-1 tumor cells
- (2011) Stefan Mergler et al. CELLULAR SIGNALLING
- The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression
- (2011) Jenny Lam et al. DRUG DEVELOPMENT RESEARCH
- Modulating antibody pharmacokinetics using hydrophilic polymers
- (2011) Chen Chen et al. Expert Opinion on Drug Delivery
- Genetic and Pharmacologic Inhibition of the Ca2+ Influx Channel TRPC3 Protects Secretory Epithelia From Ca2+-Dependent Toxicity
- (2011) Min Seuk Kim et al. GASTROENTEROLOGY
- Transgenic expression of bovine neonatal Fc receptor in mice boosts immune response and improves hybridoma production efficiency without any sign of autoimmunity
- (2011) Zita Schneider et al. IMMUNOLOGY LETTERS
- Glioma-specific Cation Conductance Regulates Migration and Cell Cycle Progression
- (2011) Arun K. Rooj et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enhancement of antibody responses to native G protein-coupled receptors using E. coli GroEL as a molecular adjuvant in DNA immunization
- (2011) Akira Fujimoto et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Autoantibodies in Melanoma-Associated Retinopathy Target TRPM1 Cation Channels of Retinal ON Bipolar Cells
- (2011) A. Dhingra et al. JOURNAL OF NEUROSCIENCE
- Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells
- (2011) Indranil Mukhopadhyay et al. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- Non-cysteine linked MUC1 cytoplasmic dimers are required for Src recruitment and ICAM-1 binding induced cell invasion
- (2011) Ashlyn J Bernier et al. Molecular Cancer
- Progressive encephalomyelitis with rigidity and myoclonus: Glycine and NMDA receptor antibodies
- (2011) M. R. Turner et al. NEUROLOGY
- Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain
- (2011) Y. Chen et al. NEUROSCIENCE
- Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis
- (2011) V Walia et al. ONCOGENE
- P2X7 receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness
- (2011) B Jelassi et al. ONCOGENE
- Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system
- (2011) Peter Holzer PHARMACOLOGY & THERAPEUTICS
- Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice
- (2011) Wendy M. Knowlton et al. PLoS One
- Rapid Internalization of the Oncogenic K+ Channel KV10.1
- (2011) Tobias Kohl et al. PLoS One
- Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis
- (2011) Y.-F. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family
- (2011) G. Duret et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The birth and postnatal development of purinergic signalling
- (2010) G. Burnstock et al. Acta Physiologica
- Extracellular ATP Is a Danger Signal Activating P2X7Receptor in Lung Inflammation and Fibrosis
- (2010) Nicolas Riteau et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Ghrelin inhibits proliferation and increases T-type Ca2+ channel expression in PC-3 human prostate carcinoma cells
- (2010) Nundehui Díaz-Lezama et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Modulating the pharmacokinetics of therapeutic antibodies
- (2010) A. Constantinou et al. BIOTECHNOLOGY LETTERS
- Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers
- (2010) S. Pillozzi et al. BLOOD
- Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels
- (2010) AP Larsen et al. BRITISH JOURNAL OF PHARMACOLOGY
- Expression and significance of HERG protein in gastric cancer
- (2010) Xiao-Dong Shao et al. CANCER BIOLOGY & THERAPY
- Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers
- (2010) Alex Cheong et al. CARDIOVASCULAR RESEARCH
- Structural Insights into the Function of P2X4: An ATP-Gated Cation Channel of Neuroendocrine Cells
- (2010) Stanko S. Stojilkovic et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Studies of ion channels using expressed protein ligation
- (2010) Paul J Focke et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Contribution of voltage-gated potassium channels to the regulation of apoptosis
- (2010) Ildikò Szabò et al. FEBS LETTERS
- Screening technologies for ion channel drug discovery
- (2010) Georg C Terstappen et al. Future Medicinal Chemistry
- Use of Venom Peptides to Probe Ion Channel Structure and Function
- (2010) Sébastien Dutertre et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of Macrophages by P2X7-Induced Microvesicles from Myeloid Cells Is Mediated by Phospholipids and Is Partially Dependent on TLR4
- (2010) L. M. Thomas et al. JOURNAL OF IMMUNOLOGY
- The Beneficial Effect of Blocking Kv1.3 in the Psoriasiform SCID Mouse Model
- (2010) Amos Gilhar et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Randomized Clinical Trial of Long-Acting Somatostatin for Autosomal Dominant Polycystic Kidney and Liver Disease
- (2010) M. C. Hogan et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma
- (2010) Xia Ding et al. JNCI-Journal of the National Cancer Institute
- Ziconotide for treatment of severe chronic pain
- (2010) Achim Schmidtko et al. LANCET
- Pharmacokinetics and lung distribution of a humanized anti-RAGE antibody in wild-type and RAGE-/-mice
- (2010) Yulia Vugmeyster et al. mAbs
- Malignant transformation in a defined genetic background: proteome changes displayed by 2D-PAGE
- (2010) Stephanie M Pütz et al. Molecular Cancer
- Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization
- (2010) Tomoyuki Igawa et al. NATURE BIOTECHNOLOGY
- International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family
- (2010) L.-J. Wu et al. PHARMACOLOGICAL REVIEWS
- Podocyte-Specific Overexpression of Wild Type or Mutant Trpc6 in Mice Is Sufficient to Cause Glomerular Disease
- (2010) Paola Krall et al. PLoS One
- Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis
- (2010) L. Di et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells
- (2010) M Flourakis et al. Cell Death & Disease
- State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy
- (2009) Sindura B. Ganapathi et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Ca2+ influx via TRPC channels induces NF-κB-dependent A20 expression to prevent thrombin-induced apoptosis in endothelial cells
- (2009) Prabhakar B. Thippegowda et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Functional Role of Canonical Transient Receptor Potential 1 and Canonical Transient Receptor Potential 3 in Normal and Asthmatic Airway Smooth Muscle Cells
- (2009) Jun-Hua Xiao et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- TRPM8 and prostate cancer: to overexpress or repress, that is the question—comment on “Effects of TRPM8 on proliferation and motility of prostate cancer PC-3 cells” by Yang ZH et al. in Asian Journal of Andrology
- (2009) Prakash Kulkarni ASIAN JOURNAL OF ANDROLOGY
- Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells
- (2009) Zhong-Hua Yang et al. ASIAN JOURNAL OF ANDROLOGY
- hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation
- (2009) V. Walia et al. CANCER RESEARCH
- Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk
- (2009) Birgit Hoeft et al. CARCINOGENESIS
- A Functional Single-Nucleotide Polymorphism in the TRPC6 Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension
- (2009) Ying Yu et al. CIRCULATION
- Calcitriol inhibits Ether-à go-go potassium channel expression and cell proliferation in human breast cancer cells
- (2009) Rocío García-Becerra et al. EXPERIMENTAL CELL RESEARCH
- Targeting voltage-gated sodium channels for pain therapy
- (2009) Jeffrey J Clare EXPERT OPINION ON INVESTIGATIONAL DRUGS
- The functional network of ion channels in T lymphocytes
- (2009) Michael D. Cahalan et al. IMMUNOLOGICAL REVIEWS
- Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells
- (2009) Rong Cai et al. INTERNATIONAL JOURNAL OF CANCER
- The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore
- (2009) M. Monif et al. JOURNAL OF NEUROSCIENCE
- Membrane Proteins Solubilized Intact in Lipid Containing Nanoparticles Bounded by Styrene Maleic Acid Copolymer
- (2009) Timothy J. Knowles et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Crofelemer, an Antisecretory Antidiarrheal Proanthocyanidin Oligomer Extracted from Croton lechleri, Targets Two Distinct Intestinal Chloride Channels
- (2009) L. Tradtrantip et al. MOLECULAR PHARMACOLOGY
- Crystal structure of the ATP-gated P2X4 ion channel in the closed state
- (2009) Toshimitsu Kawate et al. NATURE
- Chloride channels as drug targets
- (2009) Alan S. Verkman et al. NATURE REVIEWS DRUG DISCOVERY
- Voltage-gated potassium channels as therapeutic targets
- (2009) Heike Wulff et al. NATURE REVIEWS DRUG DISCOVERY
- Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels
- (2009) I. Grgic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Risk communication: the Avandia case, a pilot study
- (2009) Ragnar Lofstedt Expert Review of Clinical Pharmacology
- Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia
- (2008) K. I. Ataga et al. BLOOD
- Human embryonic stem cells and lung regeneration
- (2008) A Varanou et al. BRITISH JOURNAL OF PHARMACOLOGY
- Loss of classical transient receptor potential 6 channel reduces allergic airway response
- (2008) S. Sel et al. CLINICAL AND EXPERIMENTAL ALLERGY
- KCa3.1: target and marker for cancer, autoimmune disorder and vascular inflammation?
- (2008) Chuan-Chu Chou et al. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
- Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block
- (2008) Melanie P. Matheu et al. IMMUNITY
- Eag1 and Bestrophin 1 Are Up-regulated in Fast-growing Colonic Cancer Cells
- (2008) Melanie Spitzner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CaV3.2 T-type Calcium Channels Are Involved in Calcium-dependent Secretion of Neuroendocrine Prostate Cancer Cells
- (2008) Florian Gackière et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans
- (2008) Kazuyoshi Toyama et al. JOURNAL OF CLINICAL INVESTIGATION
- Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain
- (2008) L. Ulmann et al. JOURNAL OF NEUROSCIENCE
- Transmural variation in myosin heavy chain isoform expression modulates the timing of myocardial force generation in porcine left ventricle
- (2008) Julian E. Stelzer et al. JOURNAL OF PHYSIOLOGY-LONDON
- A nomenclature for ligand-gated ion channels
- (2008) Graham L. Collingridge et al. NEUROPHARMACOLOGY
- Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase
- (2008) Patrizia Pellegatti et al. PLoS One
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