The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression

Blunted IgE-Mediated Activation of Mast Cells in Mice Lacking the Ca2+-Activated K+ Channel KCa3.1

(2014) E. Shumilina et al.   JOURNAL OF IMMUNOLOGY

Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapo

(2011) Kenneth I. Ataga et al.   BRITISH JOURNAL OF HAEMATOLOGY

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

(2011) Tom L. Van Belle et al.   PHYSIOLOGICAL REVIEWS

KCNN4 Gene Variant Is Associated With Ileal Crohn's Disease in the Australian and New Zealand Population

(2010) Lisa A Simms et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Immunomodulatory drug treatment in multiple sclerosis

(2010) Rina Aharoni   Expert Review of Neurotherapeutics

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New pathophysiological insights and modern treatment of IBD

(2010) Matthias A. Engel et al.   JOURNAL OF GASTROENTEROLOGY

The Beneficial Effect of Blocking Kv1.3 in the Psoriasiform SCID Mouse Model

(2010) Amos Gilhar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Ulcerative colitis and cancer

(2010) Mahmoud N. Kulaylat et al.   JOURNAL OF SURGICAL ONCOLOGY

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis

(2010) L. Di et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic potential of KCa3.1 blockers: recent advances and promising trends

(2010) Heike Wulff et al.   Expert Review of Clinical Pharmacology

The K+channels KCa3.1 and Kv1.3 as novel targets for asthma therapy

(2009) Peter Bradding et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery

(2009) Ivica Grgic et al.   BRITISH JOURNAL OF PHARMACOLOGY

Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia

(2009) Kenneth I Ataga et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes

(2009) M. W. Pennington et al.   MOLECULAR PHARMACOLOGY

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels

(2009) I. Grgic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Delivery of the K Ca 3.1 Blocker, TRAM-34, Prevents Acute Angioplasty-Induced Coronary Smooth Muscle Phenotypic Modulation and Limits Stenosis

(2008) D.L. Tharp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

KCa3.1: target and marker for cancer, autoimmune disorder and vascular inflammation?

(2008) Chuan-Chu Chou et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block

(2008) Melanie P. Matheu et al.   IMMUNITY

The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans

(2008) Kazuyoshi Toyama et al.   JOURNAL OF CLINICAL INVESTIGATION

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels

(2008) Anthony J. Harmar et al.   NUCLEIC ACIDS RESEARCH

Disruption of the Gardos channel (KCa3.1) in mice causes subtle erythrocyte macrocytosis and progressive splenomegaly

(2008) Ivica Grgic et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes

(2008) Yunzhao R. Ren et al.   PLoS One