The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel

Effects of N-glycosylation of the human cation channel TRPA1 on agonist-sensitivity

(2016) T. J. Egan et al.   BIOSCIENCE REPORTS

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Crystal structure of the epithelial calcium channel TRPV6

(2016) Kei Saotome et al.   NATURE

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

(2016) Chanhyung Bae et al.   eLife

The Outer Pore and Selectivity Filter of TRPA1

(2016) Adam P. Christensen et al.   PLoS One

Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma

(2015) Cassandra E. Deering-Rice et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy

(2015) Monique S. J. Brewster et al.   BIOESSAYS

Comparative sequence analysis suggests a conserved gating mechanism for TRP channels

(2015) Eugene Palovcak et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain

(2014) Junhong Gui et al.   CURRENT BIOLOGY

Opening of an alternative ion permeation pathway in a nociceptor TRP channel

(2014) Joris Vriens et al.   Nature Chemical Biology

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel

(2012) Lucie Sura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

A conserved threonine in the S1–S2 loop of KV7.2 and KV7.3 channels regulates voltage-dependent activation

(2012) Yvonne Füll et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The transient receptor potential channel TRPA1: from gene to pathophysiology

(2012) Bernd Nilius et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Agonist-Induced Changes in Ca2+ Permeation through the Nociceptor Cation Channel TRPA1

(2010) Yuji Karashima et al.   BIOPHYSICAL JOURNAL

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement

(2010) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

N-glycans modulate Kv1.5 gating but have no effect on Kv1.4 gating

(2009) Tara A. Schwetz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular dynamics flexible fitting: A practical guide to combine cryo-electron microscopy and X-ray crystallography

(2009) Leonardo G. Trabuco et al.   METHODS

Two Separate Interfaces between the Voltage Sensor and Pore Are Required for the Function of Voltage-Dependent K+ Channels

(2009) Seok-Yong Lee et al.   PLOS BIOLOGY

The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

(2008) Yuanyuan Y. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics

(2008) Leonardo G. Trabuco et al.   STRUCTURE

HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures

(2008) Bosco K Ho et al.   BMC STRUCTURAL BIOLOGY