TRPA1 as a drug target—promise and challenges

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

(2015) Mirjam Eberhardt et al.   Nature Communications

Development of novel azabenzofuran TRPA1 antagonists as in vivo tools

(2014) Katrina W. Copeland et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout

(2014) Gabriela Trevisan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists

(2014) Lisa Rooney et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transient Receptor Potential Channel Ankyrin-1 Is Not a Cold Sensor for Autonomic Thermoregulation in Rodents

(2014) C. de Oliveira et al.   JOURNAL OF NEUROSCIENCE

Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice

(2014) Gabriela Trevisan et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Significant Determinants of Mouse Pain Behaviour

(2014) Michael S. Minett et al.   PLoS One

Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

(2014) Lavanya Moparthi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

(2014) Victor Meseguer et al.   Nature Communications

Contribution of Transient Receptor Potential Ankyrin 1 to Chronic Pain in Aged Mice With Complete Freund's Adjuvant-Induced Arthritis

(2014) Sheldon R. Garrison et al.   Arthritis & Rheumatology

Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade

(2013) G. Trevisan et al.   CANCER RESEARCH

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

(2013) Sarah R. Wilson et al.   CELL

Mechanisms involved in abdominal nociception induced by either TRPV1 or TRPA1 stimulation of rat peritoneum

(2013) Gabriela Trevisan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis

(2013) Boyi Liu et al.   FASEB JOURNAL

The Molecular Basis for Species-specific Activation of Human TRPA1 Protein by Protons Involves Poorly Conserved Residues within Transmembrane Domains 5 and 6

(2013) Jeanne de la Roche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPA1-Dependent Pruritus in IL-13-Induced Chronic Atopic Dermatitis

(2013) M.-H. Oh et al.   JOURNAL OF IMMUNOLOGY

The Ion Channel TRPA1 Is Required for Chronic Itch

(2013) S. R. Wilson et al.   JOURNAL OF NEUROSCIENCE

TRPV1 and TRPA1 Antagonists Prevent the Transition of Acute to Chronic Inflammation and Pain in Chronic Pancreatitis

(2013) E. S. Schwartz et al.   JOURNAL OF NEUROSCIENCE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Methylglyoxal Evokes Pain by Stimulating TRPA1

(2013) David A. Andersson et al.   PLoS One

Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine

(2012) Toru Kono et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Quantitative analysis of TRP channel genes in mouse organs

(2012) Yongwoo Jang et al.   ARCHIVES OF PHARMACAL RESEARCH

C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel

(2012) Lucie Sura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1)

(2012) Mirjam J. Eberhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5,6-EET Is Released upon Neuronal Activity and Induces Mechanical Pain Hypersensitivity via TRPA1 on Central Afferent Terminals

(2012) M. Sisignano et al.   JOURNAL OF NEUROSCIENCE

Recruitment of Dynamic Endothelial Ca2+Signals by the TRPA1 Channel Activator AITC in Rat Cerebral Arteries

(2012) Xun Qian et al.   MICROCIRCULATION

TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism

(2012) Serena Materazzi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells

(2012) De-Shou Cao et al.   PLoS One

TRPA1 Is a Polyunsaturated Fatty Acid Sensor in Mammals

(2012) Arianne L. Motter et al.   PLoS One

Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation

(2012) Romina Nassini et al.   PLoS One

TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation

(2012) Richard C. Lennertz et al.   PLoS One

TRPA1 Has a Key Role in the Somatic Pro-Nociceptive Actions of Hydrogen Sulfide

(2012) David A. Andersson et al.   PLoS One

TRPA1 and Substance P Mediate Colitis in Mice

(2011) Matthias A. Engel et al.   GASTROENTEROLOGY

The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons

(2011) Matthias A. Engel et al.   JOURNAL OF GASTROENTEROLOGY

Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells

(2011) Indranil Mukhopadhyay et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila

(2011) Kyeongjin Kang et al.   NATURE

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3

(2011) Eiji Shigetomi et al.   NATURE NEUROSCIENCE

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain

(2011) Y. Chen et al.   NEUROSCIENCE

Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat

(2011) Hong Wei et al.   PAIN

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

(2011) Jun Chen et al.   PAIN

Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: Sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy

(2011) Ari Koivisto et al.   PHARMACOLOGICAL RESEARCH

Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

(2011) J. F. Cordero-Morales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice

(2010) Eugene Ceppa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Met268Pro Mutation of Mouse TRPA1 Changes the Effect of Caffeine from Activation to Suppression

(2010) Katsuhiro Nagatomo et al.   BIOPHYSICAL JOURNAL

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators

(2010) Nobuaki Takahashi et al.   Channels

Recent advances in the biology and medicinal chemistry of TRPA1

(2010) Jason C Rech et al.   Future Medicinal Chemistry

Exposure to Low Temperature Induces Elevation of Intracellular Calcium in Cultured Human Keratinocytes

(2010) Moe Tsutsumi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats

(2010) Steve McGaraughty et al.   Molecular Pain

Molecular basis of infrared detection by snakes

(2010) Elena O. Gracheva et al.   NATURE

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo

(2010) Wendy M. Knowlton et al.   PAIN

Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors

(2010) Shannon D. Shields et al.   PAIN

TRPA1 Mediates Mechanical Currents in the Plasma Membrane of Mouse Sensory Neurons

(2010) Daniel Vilceanu et al.   PLoS One

Attenuation of Mechanical Hypersensitivity by an Antagonist of the TRPA1 Ion Channel in Diabetic Animals

(2009) Hong Wei et al.   ANESTHESIOLOGY

Transient Receptor Potential A1 and Cannabinoid Receptor Activity in Human Normal and Hyperplastic Prostate: Relation to Nerves and Interstitial Cells

(2009) Christian Gratzke et al.   EUROPEAN UROLOGY

Non-Neuronal Expression of Transient Receptor Potential Type A1 (TRPA1) in Human Skin

(2009) Ruzanna Atoyan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons

(2009) K. Y. Kwan et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Blockade of TRPA1 Inhibits Mechanical Firing in Nociceptors

(2009) Patrick C Kerstein et al.   Molecular Pain

TRPA1 agonists delay gastric emptying in rats through serotonergic pathways

(2009) Hitoshi Doihara et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat

(2009) Hong Wei et al.   NEUROPHARMACOLOGY

TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells

(2009) K. Nozawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPA1 acts as a cold sensor in vitro and in vivo

(2009) Y. Karashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

(2009) A. I. Caceres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPA1: A potential target for anti-tussive therapy

(2009) Thomas E. Taylor-Clark et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Plasma α-Oxoaldehyde Levels in Diabetic and Nondiabetic Chronic Kidney Disease Patients

(2008) Keisuke Nakayama et al.   AMERICAN JOURNAL OF NEPHROLOGY

Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain

(2008) Shenglan Wang et al.   BRAIN

Transient receptor potential A1 mediates an osmotically activated ion channel

(2008) Xu-Feng Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Transient Receptor Potential A1 (TRPA1) Activity in the Human Urethra—Evidence for a Functional Role for TRPA1 in the Outflow Region

(2008) Christian Gratzke et al.   EUROPEAN UROLOGY

Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases

(2008) Bret F. Bessac et al.   FASEB JOURNAL

The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

(2008) Yuanyuan Y. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPA1 is a major oxidant sensor in murine airway sensory neurons

(2008) Bret F. Bessac et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

(2008) B. Xiao et al.   JOURNAL OF NEUROSCIENCE

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE

Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels

(2008) J. Chen et al.   JOURNAL OF NEUROSCIENCE

Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal

(2008) T. E. Taylor-Clark et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cutaneous Nociception Evoked by 15-delta PGJ2 via Activation of Ion Channel TRPA1

(2008) Lillian Cruz-Orengo et al.   Molecular Pain

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

An internal thermal sensor controlling temperature preference in Drosophila

(2008) Fumika N. Hamada et al.   NATURE

Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade

(2008) Young Kwon et al.   NATURE NEUROSCIENCE

TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons

(2008) U. Anand et al.   NEUROSCIENCE LETTERS

Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

(2007) Tomi Streng et al.   EUROPEAN UROLOGY