标题
Ion channel drug discovery: challenges and future directions
作者
关键词
-
出版物
Future Medicinal Chemistry
Volume 4, Issue 5, Pages 661-679
出版商
Future Science, LTD
发表日期
2012-03-29
DOI
10.4155/fmc.12.4
参考文献
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- (2011) G. L. Krauss et al. ACTA NEUROLOGICA SCANDINAVICA
- Cyclopropyl Carboxamides, a Chemically Novel Class of Antimalarial Agents Identified in a Phenotypic Screen
- (2011) Laura M. Sanz et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Potentiation of analgesic efficacy but not side effects: Co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats
- (2011) Chang Z. Zhu et al. BIOCHEMICAL PHARMACOLOGY
- α4β2 neuronal nicotinic receptor positive allosteric modulation: An approach for improving the therapeutic index of α4β2 nAChR agonists in pain
- (2011) Chih-Hung Lee et al. BIOCHEMICAL PHARMACOLOGY
- Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapo
- (2011) Kenneth I. Ataga et al. BRITISH JOURNAL OF HAEMATOLOGY
- Transsynaptic channelosomes
- (2011) Hiroshi Nishimune Channels
- Neuronal Store-Operated Calcium Entry Pathway as a Novel Therapeutic Target for Huntington's Disease Treatment
- (2011) Jun Wu et al. CHEMISTRY & BIOLOGY
- 1990–2010: Two Decades of Interferon-Based Therapy
- (2011) Maria Buti et al. Clinics in Liver Disease
- Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
- (2011) Masayuki Yazawa et al. NATURE
- Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist
- (2011) Shu-Xing Li et al. NATURE NEUROSCIENCE
- Excitement mounts for first disease-modifying cystic fibrosis drugs
- (2011) Alisa Opar NATURE REVIEWS DRUG DISCOVERY
- A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain
- (2011) Michael E. Hildebrand et al. PAIN
- Translational PK–PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576
- (2011) Roberta Bursi et al. PSYCHOPHARMACOLOGY
- Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases
- (2011) Victor Chi et al. TOXICON
- Profiling Diverse Compounds by Flux- and Electrophysiology-Based Primary Screens for Inhibition of Human Ether-à-go-go Related Gene Potassium Channels
- (2010) Beiyan Zou et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening
- (2010) Emily Dick et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Identification of novel α7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods
- (2010) Anna Maria Capelli et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Structure based evolution of a novel series of positive modulators of the AMPA receptor
- (2010) Craig Jamieson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist
- (2010) Joel R Gever et al. BRITISH JOURNAL OF PHARMACOLOGY
- Challenges for and current status of research into positive modulators of AMPA receptors
- (2010) Simon E Ward et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacotherapy of Epilepsy
- (2010) Linda J. Stephen et al. CNS DRUGS
- Update on local anesthetics
- (2010) Alain Borgeat et al. Current Opinion in Anesthesiology
- Screening technologies for ion channel drug discovery
- (2010) Georg C Terstappen et al. Future Medicinal Chemistry
- Understanding ion channels using computational approaches
- (2010) Marcel J de Groot Future Medicinal Chemistry
- Natural products and ion channel pharmacology
- (2010) Russell W Teichert et al. Future Medicinal Chemistry
- High-throughput Screening in Embryonic Stem Cell-derived Neurons Identifies Potentiators of α-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type Glutamate Receptors
- (2010) John McNeish et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- In SilicoDocking and Electrophysiological Characterization of Lacosamide Binding Sites on Collapsin Response Mediator Protein-2 Identifies a Pocket Important in Modulating Sodium Channel Slow Inactivation
- (2010) Yuying Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Non-conducting function of the Kv2.1 channel enables it to recruit vesicles for release in neuroendocrine and nerve cells
- (2010) L. Feinshreiber et al. JOURNAL OF CELL SCIENCE
- Implementation of a Fluorescence-Based Screening Assay Identifies Histamine H3 Receptor Antagonists Clobenpropit and Iodophenpropit as Subunit-Selective N-Methyl-D-Aspartate Receptor Antagonists
- (2010) K. B. Hansen et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Unknown
- (2010) T. Dinklo et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Analgesic Effects of a Substituted N-Triazole Oxindole (TROX-1), a State-Dependent, Voltage-Gated Calcium Channel 2 Blocker
- (2010) C. Abbadie et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Sodium and Potassium Balance Depends on ENaC Expression in Connecting Tubule
- (2010) B. M. Christensen et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy
- (2010) Boris S. Ermolinsky et al. NEUROSCIENCE RESEARCH
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- (2010) B. Coste et al. SCIENCE
- Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes
- (2010) M. Schieder et al. Science Signaling
- Combination of Functional Cardiomyocytes Derived from Human Stem Cells and a Highly-Efficient Microelectrode Array System: An Ideal Hybrid Model Assay for Drug Development
- (2010) Yasuyuki Asai et al. Current Stem Cell Research & Therapy
- Varenicline in smoking cessation
- (2010) Serena Tonstad et al. Expert Review of Respiratory Medicine
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- (2009) Laetitia Mony et al. BRITISH JOURNAL OF PHARMACOLOGY
- Novel trends in high-throughput screening
- (2009) Lorenz M Mayr et al. CURRENT OPINION IN PHARMACOLOGY
- The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat
- (2009) Charles H. Large et al. EPILEPSY RESEARCH
- Venomics as a drug discovery platform
- (2009) Pierre Escoubas et al. Expert Review of Proteomics
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- (2009) Miroslava Stastna et al. FEBS LETTERS
- Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen
- (2009) John McLaughlin et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
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- (2009) Janne Jensen et al. JOURNAL OF CELLULAR PHYSIOLOGY
- High-Throughput Screening Reveals a Small-Molecule Inhibitor of the Renal Outer Medullary Potassium Channel and Kir7.1
- (2009) L. M. Lewis et al. MOLECULAR PHARMACOLOGY
- Open innovation networks between academia and industry: an imperative for breakthrough therapies
- (2009) Teri Melese et al. NATURE MEDICINE
- An Automated Electrophysiology Serum Shift Assay for KV Channels
- (2008) Kevin S. Ratliff et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia
- (2008) K. I. Ataga et al. BLOOD
- Production of a specific extracellular inhibitor of TRPM3 channels
- (2008) J Naylor et al. BRITISH JOURNAL OF PHARMACOLOGY
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- (2008) Ravi D. Rao et al. CANCER
- Ion Channel Screening
- (2008) John Dunlop et al. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
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- (2008) Qiang Lu et al. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
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- (2008) A HARVEY DRUG DISCOVERY TODAY
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- (2008) Martin D. Tobin et al. HYPERTENSION
- Human embryonic stem cells for cardiomyogenesis
- (2008) Manhal Habib et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Weighing the evidence for a ternary protein complex mediating A-type K+currents in neurons
- (2008) Jonathon Maffie et al. JOURNAL OF PHYSIOLOGY-LONDON
- Rare independent mutations in renal salt handling genes contribute to blood pressure variation
- (2008) Weizhen Ji et al. NATURE GENETICS
- Drug development from marine natural products
- (2008) Tadeusz F. Molinski et al. NATURE REVIEWS DRUG DISCOVERY
- Human embryonic stem cells: Current technologies and emerging industrial applications
- (2007) Caroline Améen et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
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