Xyloketal B Suppresses Glioblastoma Cell Proliferation and Migration in Vitro through Inhibiting TRPM7-Regulated PI3K/Akt and MEK/ERK Signaling Pathways

TRPM7 regulates vascular endothelial cell adhesion and tube formation

(2015) Zhao Zeng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Trabectedin therapy as an emerging treatment strategy for recurrent platinum-sensitive ovarian cance

(2015) Jose Antonio Lopez-Guerrero et al.   Chinese Journal of Cancer

Overexpression of TRPM7 is Associated with Poor Prognosis in Human Ovarian Carcinoma

(2014) Jing Wang et al.   Asian Pacific Journal of Cancer Prevention

TRPM7 is required for ovarian cancer cell growth, migration and invasion

(2014) Jing Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways

(2014) Mingli Liu et al.   CELLULAR SIGNALLING

Suppression of TRPM7 Inhibits Proliferation, Migration, and Invasion of Malignant Human Glioma Cells

(2014) Tian-Dong Leng et al.   CNS Neuroscience & Therapeutics

Marine Compound Xyloketal B Reduces Neonatal Hypoxic-Ischemic Brain Injury

(2014) Ai-Jiao Xiao et al.   Marine Drugs

Standards of care and novel approaches in the management of glioblastoma multiforme

(2014) Andreas F. Hottinger et al.   Chinese Journal of Cancer

Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer

(2014) Nelson Yee et al.   Cells

TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway

(2013) Xiaojing Meng et al.   CANCER LETTERS

Inhibition of TRPM7 channels prevents proliferation and differentiation of human lung fibroblasts

(2013) Mingzhe Yu et al.   INFLAMMATION RESEARCH

Xyloketal B Exhibits Its Antioxidant Activity through Induction of HO-1 in Vascular Endothelial Cells and Zebrafish

(2013) Zhen-Xing Li et al.   Marine Drugs

Synthesis and Neuroprotective Action of Xyloketal Derivatives in Parkinson’s Disease Models

(2013) Shichang Li et al.   Marine Drugs

TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways

(2013) Ling Fang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C γ2 (PLCγ2) using TRPM7-kinase

(2012) Francina Deason-Towne et al.   CELLULAR SIGNALLING

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches

(2012) Antonella De Luca et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration

(2012) Pierre Rybarczyk et al.   INTERNATIONAL JOURNAL OF CANCER

Current clinical development of PI3K pathway inhibitors in glioblastoma

(2012) P. Y. Wen et al.   NEURO-ONCOLOGY

Involvement of Kv1.5 Protein in Oxidative Vascular Endothelial Cell Injury

(2012) Wen-Liang Chen et al.   PLoS One

Ion channnels and transporters in cancer. 5. Ion channels in control of cancer and cell apoptosis

(2011) V'yacheslav Lehen'kyi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeting the AKT Pathway in Glioblastoma

(2011) Kelli A. McDowell et al.   CURRENT PHARMACEUTICAL DESIGN

Intrathecal combination of ziconotide and morphine for refractory cancer pain: A rapidly acting and effective choice

(2011) Ilaria Alicino et al.   PAIN

Protective effects of xyloketal B against MPP+-induced neurotoxicity in Caenorhabditis elegans and PC12 cells

(2010) Xi-lin Lu et al.   BRAIN RESEARCH

Molecular Interaction and Functional Regulation of ClC-3 by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) in Human Malignant Glioma

(2010) Vishnu Anand Cuddapah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Synthesis of Novel Xyloketal Derivatives and Their Vasorelaxing Activities in Rat Thoracic Aorta and Angiogenic Activities in Zebrafish Angiogenesis Screen

(2010) Zhongliang Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crosstalk Between the PI3K/mTOR and MEK/ERK Pathways Involved in the Maintenance of Self-Renewal and Tumorigenicity of Glioblastoma Stem-Like Cells

(2010) Jun Sunayama et al.   STEM CELLS

Designer Therapies for Glioblastoma Multiforme

(2009) Sith Sathornsumetee et al.   Annals of the New York Academy of Sciences

A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro

(2009) Wen-Liang Chen et al.   BIOCHEMICAL PHARMACOLOGY

Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damage

(2009) Jia Zhao et al.   BRAIN RESEARCH

ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity

(2009) Lianyan Huang et al.   CARCINOGENESIS

Silencing TRPM7 promotes growth/proliferation and nitric oxide production of vascular endothelial cells via the ERK pathway

(2009) Koichi Inoue et al.   CARDIOVASCULAR RESEARCH

Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels

(2009) Moshe Parnas et al.   CELL CALCIUM

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia

(2009) Hong-Shuo Sun et al.   NATURE NEUROSCIENCE

TRPM7 Regulates Myosin IIA Filament Stability and Protein Localization by Heavy Chain Phosphorylation

(2008) Kristopher Clark et al.   JOURNAL OF MOLECULAR BIOLOGY

Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg2+ Homeostasis

(2008) J. Jin et al.   SCIENCE