T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers

Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma

(2014) Shyny Koshy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Ion Channel Kv1.3 with Scorpion Venom Peptides Engineered for Potency, Selectivity, and Half-life

(2014) Wilson Edwards et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering a Potent and Specific Blocker of Voltage-Gated Potassium Channel Kv1.3, a Target for Autoimmune Diseases

(2012) Rong Chen et al.   BIOCHEMISTRY

Modeling the Binding of Three Toxins to the Voltage-Gated Potassium Channel (Kv1.3)

(2011) Rong Chen et al.   BIOPHYSICAL JOURNAL

Regulation of NF-κB induction by TCR/CD28

(2011) Jing Cheng et al.   IMMUNOLOGIC RESEARCH

T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells

(2011) K. Adachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

(2011) Victor Chi et al.   TOXICON

CTLA4-Ig inhibits allergic airway inflammation by a novel CD28-independent, nitric oxide synthase-dependent mechanism

(2010) Christine M. Deppong et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Beneficial Effect of Blocking Kv1.3 in the Psoriasiform SCID Mouse Model

(2010) Amos Gilhar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating

(2009) L. Sole et al.   JOURNAL OF CELL SCIENCE

Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes

(2009) M. W. Pennington et al.   MOLECULAR PHARMACOLOGY

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Blockade of T-Lymphocyte KCa3.1 and Kv1.3 Channels as Novel Immunosuppression Strategy to Prevent Kidney Allograft Rejection

(2009) I. Grgic et al.   TRANSPLANTATION PROCEEDINGS

Inhibitor of sarco-endoplasmic reticulum Ca2+-ATPase thapsigargin stimulates production of nitric oxide and secretion of interferon-gamma

(2008) Eva Kmoníčková et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block

(2008) Melanie P. Matheu et al.   IMMUNITY

Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes

(2008) Yunzhao R. Ren et al.   PLoS One

Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

(2008) I. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae

(2008) Yousra Abdel-Mottaleb et al.   TOXICON