Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7

Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models

(2017) Ai-Ling Li et al.   Neuroscience Bulletin

Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel

(2017) Wonseok Chang et al.   Neuroscience Bulletin

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins

(2016) Fabian Higel et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli

(2016) Y. Yang et al.   JOURNAL OF NEUROSCIENCE

Cysteinylation of a monoclonal antibody leads to its inactivation

(2016) Troy McSherry et al.   mAbs

SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons

(2016) Qingjian Han et al.   NEURON

Modulation of Nav1.8 by Lysophosphatidic Acid in the Induction of Bone Cancer Pain

(2016) Hai-Li Pan et al.   Neuroscience Bulletin

Human Nav1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons

(2015) Chongyang Han et al.   JOURNAL OF NEUROPHYSIOLOGY

Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

(2015) Zhen-Zhong Xu et al.   NATURE MEDICINE

Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain

(2015) W. Xie et al.   NEUROSCIENCE

Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7

(2015) Michael S. Minett et al.   Nature Communications

A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

(2014) Jun-Ho Lee et al.   CELL

Painful and painless channelopathies

(2014) David L H Bennett et al.   LANCET NEUROLOGY

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies

(2014) Markus Haberger et al.   mAbs

Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain

(2014) Marco Sisignano et al.   Nature Reviews Neurology

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

(2013) Cédric J. Laedermann et al.   JOURNAL OF CLINICAL INVESTIGATION

Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia

(2013) Wenrui Xie et al.   PAIN

Painful Na-channelopathies: an expanding universe

(2013) Stephen G. Waxman   TRENDS IN MOLECULAR MEDICINE

Co-expression of NaVβ subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins

(2012) Min-Min Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Voltage-gated sodium channels at 60: structure, function and pathophysiology

(2012) William A. Catterall   JOURNAL OF PHYSIOLOGY-LONDON

Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies

(2012) Yi Du et al.   mAbs

Expression of Nav1.7 in DRG Neurons Extends from Peripheral Terminals in the Skin to Central Preterminal Branches and Terminals in the Dorsal Horn

(2012) Joel A Black et al.   Molecular Pain

Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+Channel Voltage Sensors in Domains II and IV

(2011) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss-of-function mutations in sodium channel Nav1.7 cause anosmia

(2011) Jan Weiss et al.   NATURE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Sodium channel SCN1A and epilepsy: Mutations and mechanisms

(2010) Andrew Escayg et al.   EPILEPSIA

The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation

(2010) Y. Xiao et al.   MOLECULAR PHARMACOLOGY

Sodium channelopathies of skeletal muscle result from gain or loss of function

(2010) Karin Jurkat-Rott et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Large A-Fiber Activity is Required for Microglial Proliferation and P38 MAPK Activation in the Spinal Cord: Different Effects of Resiniferatoxin and Bupivacaine on Spinal Microglial Changes after Spared Nerve Injury

(2009) Marc R Suter et al.   Molecular Pain

Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models

(2009) W. Xie et al.   NEUROSCIENCE

Continuous  -Opioid Receptor Activation Reduces Neuronal Voltage-Gated Sodium Channel (NaV1.7) Levels through Activation of Protein Kinase C in Painful Diabetic Neuropathy

(2008) M. Chattopadhyay et al.   JOURNAL OF NEUROSCIENCE

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

SCN5A channelopathies – An update on mutations and mechanisms

(2008) Thomas Zimmer et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Removal of Cysteinylation from an Unpaired Sulfhydryl in the Variable Region of a Recombinant Monoclonal IgG1 Antibody Improves Homogeneity, Stability, and Biological Activity

(2007) Douglas D. Banks et al.   JOURNAL OF PHARMACEUTICAL SCIENCES