Schmerz und Schmerzlosigkeit

Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9

(2016) Voraluck Phatarakijnirund et al.   BONE

Painful small fiber neuropathy with gastroparesis: A new phenotype with a novel mutation in the SCN10A gene

(2016) Ron Dabby et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Short-lasting unilateral neuralgiform headache attacks with ispilateral facial flushing is a new variant of paroxysmal extreme pain disorder

(2015) Noboru Imai et al.   JOURNAL OF HEADACHE AND PAIN

Human Nav1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons

(2015) Chongyang Han et al.   JOURNAL OF NEUROPHYSIOLOGY

Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7

(2015) Michael S. Minett et al.   Nature Communications

The Nav1.9 Channel Is a Key Determinant of Cold Pain Sensation and Cold Allodynia

(2015) Stéphane Lolignier et al.   Cell Reports

Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy

(2014) Jianying Huang et al.   BRAIN

Neuropathic pain in two-generation twins carrying the sodium channel Nav1.7 functional variant R1150W

(2014) Judith U. Harrer et al.   PAIN

Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain

(2013) Xiang Yang Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inherited Pain

(2013) Mirjam Eberhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The G1662S NaV1.8 mutation in small fibre neuropathy: impaired inactivation underlying DRG neuron hyperexcitability

(2013) C. Han et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Small-Fiber Neuropathy Nav1.8 Mutation Shifts Activation to Hyperpolarized Potentials and Increases Excitability of Dorsal Root Ganglion Neurons

(2013) J. Huang et al.   JOURNAL OF NEUROSCIENCE

A de novo gain-of-function mutation in SCN11A causes loss of pain perception

(2013) Enrico Leipold et al.   NATURE GENETICS

Hereditary sensory and autonomic neuropathy type IID caused by an SCN9A mutation

(2013) J. Yuan et al.   NEUROLOGY

Painful Na-channelopathies: an expanding universe

(2013) Stephen G. Waxman   TRENDS IN MOLECULAR MEDICINE

Neuropathy-associated NaV1.7 variant I228M impairs integrity of dorsal root ganglion neuron axons

(2012) Anna-Karin Persson et al.   ANNALS OF NEUROLOGY

A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia

(2012) Gilberto Vargas-Alarcon et al.   BMC MUSCULOSKELETAL DISORDERS

Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects

(2012) Tomiyasu Arisawa et al.   JOURNAL OF GASTROENTEROLOGY

The Non-Synonymous SNP, R1150W, in SCN9A is Not Associated with Chronic Widespread Pain Susceptibility

(2012) Kate L Holliday et al.   Molecular Pain

Small-fibre neuropathies—advances in diagnosis, pathophysiology and management

(2012) Janneke G. Hoeijmakers et al.   Nature Reviews Neurology

The NaV1.7 sodium channel: from molecule to man

(2012) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

Gain-of-function Nav1.8 mutations in painful neuropathy

(2012) C. G. Faber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

(2012) Michael S. Minett et al.   Nature Communications

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

(2011) Catharina G. Faber et al.   ANNALS OF NEUROLOGY

Genetic tracing of Nav1.8-expressing vagal afferents in the mouse

(2011) Laurent Gautron et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Intra- and Interfamily Phenotypic Diversity in Pain Syndromes Associated with a Gain-of-Function Variant of NaV1.7

(2011) Mark Estación et al.   Molecular Pain

Treatment of Nav1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker

(2011) Yigal Paul Goldberg et al.   PAIN

Two NovelSCN9AGene Heterozygous Mutations May Cause Partial Deletion of Pain Perception

(2011) Ruimei Yuan et al.   PAIN MEDICINE

Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia

(2010) Jin-Sung Choi et al.   BRAIN

Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons

(2010) Jin-Sung Choi et al.   Nature Reviews Neurology

A sodium channel geneSCN9Apolymorphism that increases nociceptor excitability

(2009) Mark Estacion et al.   ANNALS OF NEUROLOGY

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia

(2009) Tanya Z. Fischer et al.   ANNALS OF NEUROLOGY

Mexiletine-responsive erythromelalgia due to a new Nav1.7 mutation showing use-dependent current fall-off

(2009) Jin-Sung Choi et al.   EXPERIMENTAL NEUROLOGY

NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders

(2008) M. Estacion et al.   JOURNAL OF NEUROSCIENCE