The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies

PDGFR-β inhibitor slows tumor growth but increases metastasis in combined radiotherapy and Endostar therapy

(2018) Limei Yin et al.   BIOMEDICINE & PHARMACOTHERAPY

Montelukast inhibits hypoxia inducible factor-1α translation in prostate cancer cells

(2018) Caixia Tang et al.   CANCER BIOLOGY & THERAPY

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial–mesenchymal transition and stemness

(2018) Jingjing Wang et al.   CANCER LETTERS

PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα

(2018) Higinio Dopeso et al.   CANCER RESEARCH

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

Hypoxia-induced HMGB1 expression of HCC promotes tumor invasiveness and metastasis via regulating macrophage-derived IL-6

(2018) Jiang Jiang et al.   EXPERIMENTAL CELL RESEARCH

Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment

(2018) Jingying Zhang et al.   HEPATOLOGY

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis

(2018) Yan Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma

(2018) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Intermittent hypoxia induces a metastatic phenotype in breast cancer

(2018) Anna Chen et al.   ONCOGENE

TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma

(2018) Hitoshi Itoh et al.   ONCOGENE

Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins

(2018) Kalpana Deepa Priya Dorayappan et al.   ONCOGENE

HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice

(2018) Claire-Sophie Devignes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer

(2018) Yen-An Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemotherapy induces enrichment of CD47+/CD73+/PDL1+immune evasive triple-negative breast cancer cells

(2018) Debangshu Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases

(2018) Ying Shan et al.   Cell Death & Disease

Pro-inflammatory cytokines activate hypoxia-inducible factor 3α via epigenetic changes in mesenchymal stromal/stem cells

(2018) Francesca Cuomo et al.   Scientific Reports

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer

(2018) James R.W. Conway et al.   Cell Reports

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells

(2017) Yangyang Shang et al.   EXPERIMENTAL CELL RESEARCH

The interplay between the cellular hypoxic response and Notch signaling

(2017) Sebastian K.-J. Landor et al.   EXPERIMENTAL CELL RESEARCH

Hypoxia stimulates invasion and migration of human cervical cancer cell lines HeLa/SiHa through the Rab11 trafficking of integrin αvβ3/FAK/PI3K pathway-mediated Rac1 activation

(2017) Hao Xu et al.   JOURNAL OF BIOSCIENCES

Metastatic Breast Cancer Cells Enter Into Dormant State and Express Cancer Stem Cells Phenotype Under Chronic Hypoxia

(2017) Alessandra Carcereri de Prati et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): A “structure-activity relationship” perspective

(2017) Deepak Bhattarai et al.   MEDICINAL RESEARCH REVIEWS

A prospective multicenter cohort study of cutaneous melanoma

(2017) Miguel Ángel Martínez-García et al.   MELANOMA RESEARCH

Hypoxia-inducible microRNA-224 promotes the cell growth, migration and invasion by directly targeting RASSF8 in gastric cancer

(2017) Chuan He et al.   Molecular Cancer

Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

(2017) Qi Zhang et al.   Molecular Cancer

HIF-3α Promotes Metastatic Phenotypes in Pancreatic Cancer by Transcriptional Regulation of the RhoC–ROCK1 Signaling Pathway

(2017) Xianfei Zhou et al.   MOLECULAR CANCER RESEARCH

Hypoxia Selectively Enhances Integrin α 5 β 1 Receptor Expression in Breast Cancer to Promote Metastasis

(2017) Julia A. Ju et al.   MOLECULAR CANCER RESEARCH

Diallyl trisulfides, a natural histone deacetylase inhibitor, attenuate HIF-1α synthesis, and decreases breast cancer metastasis

(2017) Zhonghong Wei et al.   MOLECULAR CARCINOGENESIS

Cell plasticity in epithelial homeostasis and tumorigenesis

(2017) Julia Varga et al.   NATURE CELL BIOLOGY

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

(2017) Georg Fluegen et al.   NATURE CELL BIOLOGY

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin β4/FAK/SOX2/HIF-1α signaling pathway in gastric cancer

(2017) L Gan et al.   ONCOGENE

Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

(2017) Y-L Hsu et al.   ONCOGENE

Exosomes Derived From Hypoxic Colorectal Cancer Cells Promote Angiogenesis Through Wnt4-Induced β-Catenin Signaling in Endothelial Cells

(2017) Zhe Huang et al.   ONCOLOGY RESEARCH

Expression of Hypoxia-Associated Protein HIF-1α in Follicular Thyroid Cancer is Associated with Distant Metastasis

(2017) Aumayr Klaus et al.   PATHOLOGY & ONCOLOGY RESEARCH

Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes

(2017) Toshiro Hara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis

(2017) Francesco Casciello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer

(2017) Arman Jahangiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increasing AR by HIF-2α inhibitor (PT-2385) overcomes the side-effects of sorafenib by suppressing hepatocellular carcinoma invasion via alteration of pSTAT3, pAKT and pERK signals

(2017) Junjie Xu et al.   Cell Death & Disease

Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression

(2017) Juan Liu et al.   Nature Communications

Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway

(2017) Ying Pang et al.   Oncotarget

Intratumoral Cancer Cell Intravasation Can Occur Independent of Invasion into the Adjacent Stroma

(2017) Elena I. Deryugina et al.   Cell Reports

Hypoxic Stress-Induced Tumor and Immune Plasticity, Suppression, and Impact on Tumor Heterogeneity

(2017) Stéphane Terry et al.   Frontiers in Immunology

Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19 F–MRI and Multispectral Analysis

(2017) Yunzhou Shi et al.   NEOPLASIA

Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines

(2017) Koichi Baba et al.   Scientific Reports

Hypoxia-inducible factor 3 biology: complexities and emerging themes

(2016) Cunming Duan   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cycling hypoxia: A key feature of the tumor microenvironment

(2016) Carine Michiels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

EMT, cell plasticity and metastasis

(2016) Christine L. Chaffer et al.   CANCER AND METASTASIS REVIEWS

A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1α

(2016) Fan Wang et al.   CANCER BIOLOGY & THERAPY

Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma

(2016) Alina Filatova et al.   CANCER RESEARCH

Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle-Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer

(2016) E. Pham et al.   CANCER RESEARCH

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis

(2016) D. Samanta et al.   CANCER RESEARCH

Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype

(2016) Ling Li et al.   CANCER RESEARCH

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

(2016) L.-Y. Ye et al.   CANCER RESEARCH

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

(2016) Eli M. Wallace et al.   CANCER RESEARCH

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

(2016) Kimberly J. Briggs et al.   CELL

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions

(2016) Stephen P. Burr et al.   Cell Metabolism

Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue

(2016) Wenjun Zhao et al.   CELLULAR SIGNALLING

Cancer Tills the Premetastatic Field: Mechanistic Basis and Clinical Implications

(2016) A. R. Chin et al.   CLINICAL CANCER RESEARCH

A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer

(2016) Stephen M Hatfield et al.   CURRENT OPINION IN PHARMACOLOGY

Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer

(2016) Maria Raffaella Ambrosio et al.   Diagnostic Pathology

Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma

(2016) Alan Ka-Lun Kai et al.   HEPATOLOGY

Hypoxia-inducible proteins HIF1α and lactate dehydrogenase LDH5, key markers of anaerobic metabolism, relate with stem cell markers and poor post-radiotherapy outcome in bladder cancer

(2016) Michael I. Koukourakis et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

The impact of hypoxia and its modification of the outcome of radiotherapy

(2016) Michael R. Horsman et al.   JOURNAL OF RADIATION RESEARCH

FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model

(2016) C. Gstalder et al.   MOLECULAR CANCER THERAPEUTICS

Biglycan stimulates VEGF expression in endothelial cells by activating the TLR signaling pathway

(2016) Lei Hu et al.   Molecular Oncology

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

(2016) Bernard Thienpont et al.   NATURE

Targeting renal cell carcinoma with a HIF-2 antagonist

(2016) Wenfang Chen et al.   NATURE

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

(2016) Hyejin Cho et al.   NATURE

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

(2016) Rachelle W. Johnson et al.   NATURE CELL BIOLOGY

The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations

(2016) H Endo et al.   ONCOGENE

Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1α and ITGβ1 expression

(2016) YUANYI XU et al.   ONCOLOGY REPORTS

Combined over-expression of the hypoxia-inducible factor 2α gene and its long non-coding RNA predicts unfavorable prognosis of patients with osteosarcoma

(2016) Wei Li et al.   PATHOLOGY RESEARCH AND PRACTICE

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts

(2016) Xiaomeng Zhang et al.   PLoS One

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

(2016) N. N. Rahbari et al.   Science Translational Medicine

Knockdown of Hypoxia-Inducible Factor 1α Improved the Efficacy of Low-Dose Metronomic Chemotherapy of Paclitaxel in Human Colon Cancer Xenografts

(2016) Mu Zhang et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Exosome-Mediated Metastasis: From Epithelial–Mesenchymal Transition to Escape from Immunosurveillance

(2016) Nicholas Syn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Expression of glucose transporter-1 is correlated with hypoxia-inducible factor 1α and malignant potential in pancreatic neuroendocrine tumors

(2016) Minoru Fujino et al.   Oncology Letters

EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance

(2016) C. Depner et al.   Nature Communications

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

(2016) Michael S. Nakazawa et al.   Nature Communications

HIF-3α1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signaling

(2016) Xiang Xue et al.   Oncotarget

Nuclear β-arrestin1 is a critical cofactor of hypoxia-inducible factor-1α signaling in endothelin-1-induced ovarian tumor progression

(2016) Roberta Cianfrocca et al.   Oncotarget

The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models

(2016) Yun-Rong Zhu et al.   Oncotarget

Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia

(2016) Eun-Taex Oh et al.   Scientific Reports

Expression of HIF-2αand VEGF in Cervical Squamous Cell Carcinoma and Its Clinical Significance

(2016) Lixia Zhang et al.   Biomed Research International

Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells

(2016) Paul R. Coleman et al.   Aging-US

The relationship between the preoperative plasma level of HIF-1α and clinic pathological features, prognosis in non-small cell lung cancer

(2016) Jiabei He et al.   Scientific Reports

Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer

(2015) Xiao Zhao et al.   BIOMATERIALS

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

(2015) Amal M. El-Naggar et al.   CANCER CELL

PI3K–mTORC2 but not PI3K–mTORC1 Regulates Transcription of HIF2A/EPAS1 and Vascularization in Neuroblastoma

(2015) Sofie Mohlin et al.   CANCER RESEARCH

Extracellular Metabolic Energetics Can Promote Cancer Progression

(2015) Jia Min Loo et al.   CELL

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

(2015) Antero Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Gain of HIF-1  under Normoxia in Cancer Mediates Immune Adaptation through the AKT/ERK and VEGFA Axes

(2015) Y.-H. Lee et al.   CLINICAL CANCER RESEARCH

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

(2015) C. D. Madsen et al.   EMBO REPORTS

HIF3α: the little we know

(2015) Linda Ravenna et al.   FEBS Journal

Interplay between receptor tyrosine kinases and hypoxia signaling in cancer

(2015) Astrid A. Glück et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition

(2015) L. MAVROEIDIS et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing

(2015) Andrés Tittarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and significance of HIF-1α and HIF-2α in pancreatic cancer

(2015) Min Wang et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Role of exosomes and microvesicles in hypoxia-associated tumour development and cardiovascular disease

(2015) M. Belting et al.   JOURNAL OF INTERNAL MEDICINE

Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment

(2015) Fares Nigim et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions

(2015) Hiroki Ushijima et al.   JOURNAL OF RADIATION RESEARCH

Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species-mediated B-cell lymphoma extra-long pathway in glioblastoma multiforme

(2015) Wei-Ling Chen et al.   Journal of Translational Medicine

Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)

(2015) SHENG-LI YANG et al.   Molecular Medicine Reports

Monitoring vascular normalization induced by antiangiogenic treatment with 18F-fluoromisonidazole-PET

(2015) Elena Hernández-Agudo et al.   Molecular Oncology

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

(2015) Thomas R. Cox et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

mRNA expression levels of hypoxia-induced and stem cell-associated genes in human glioblastoma

(2015) MATTHIAS BACHE et al.   ONCOLOGY REPORTS

Serial [18F]-fluoromisonidazole PET during radiochemotherapy for locally advanced head and neck cancer and its correlation with outcome

(2015) Nicole E. Wiedenmann et al.   RADIOTHERAPY AND ONCOLOGY

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression

(2015) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Epigenetic regulation by histone demethylases in hypoxia

(2015) Rebecca L Hancock et al.   Epigenomics

The regulation of cancer cell migration by lung cancer cell-derived exosomes through TGF-β and IL-10

(2015) YUZHOU WANG et al.   Oncology Letters

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

(2015) Yoko Goto et al.   Nature Communications

A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells

(2015) Chih-Chien Chou et al.   Oncotarget

HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGFβ-signaling in hypoxic microenvironment.

(2015) Neha Nagpal et al.   Scientific Reports

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

(2015) Anna Kuchnio et al.   Cell Reports

Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non-aggressive neighbouring cells

(2015) A Herrmann et al.   Oncogenesis

Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors

(2015) Pierre Danhier et al.   NEOPLASIA

Cycling Hypoxia Induces a Specific Amplified Inflammatory Phenotype in Endothelial Cells and Enhances Tumor-Promoting Inflammation In Vivo

(2015) Céline Tellier et al.   NEOPLASIA

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

(2015) Guy Berchem et al.   OncoImmunology

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer

(2015) Wenjing Zhang et al.   PLoS One

Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma

(2015) Tiansuo Zhao et al.   Oncotarget

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

(2015) Lisha Xiang et al.   Oncotarget

Regulation of Membrane-Type 4 Matrix Metalloproteinase by SLUG Contributes to Hypoxia-Mediated Metastasis

(2015) Chi-Hung Huang et al.   NEOPLASIA

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

(2014) Joseph C. Walsh et al.   ANTIOXIDANTS & REDOX SIGNALING

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

(2014) T. Umezu et al.   BLOOD

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Translational Impact of Nanoparticle-Drug Conjugate CRLX101 with or without Bevacizumab in Advanced Ovarian Cancer

(2014) E. Pham et al.   CLINICAL CANCER RESEARCH

Poor prognosis and advanced clinicopathological features of clear cell renal cell carcinoma (ccRCC) are associated with cytoplasmic subcellular localisation of Hypoxia inducible factor-2α

(2014) Nils Kroeger et al.   EUROPEAN JOURNAL OF CANCER

Hypoxia-regulated gene network in drug resistance and cancer progression

(2014) Shao-Chieh Lin et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Upregulation of BNIP3 mediated by ERK/HIF-1α pathway induces autophagy and contributes to anoikis resistance of hepatocellular carcinoma cells

(2014) Lei Sun et al.   Future Oncology

Prognosis value of HIF-1α expression in patients with non-small cell lung cancer

(2014) Qian Wang et al.   GENE

Sox9 and Hif-2α regulate TUBB3 gene expression and affect ovarian cancer aggressiveness

(2014) Giuseppina Raspaglio et al.   GENE

Overexpression of Hypoxia-Inducible Factor-1α Is a Predictor of Poor Prognosis in Cervical Cancer

(2014) Miaoling Huang et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

HIF2α is associated with poor prognosis and affects the expression levels of survivin and cyclin D1 in gastric carcinoma

(2014) WEI-WEI TONG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Prognostic Potential of DNA Methylation and Transcript Levels of HIF1A and EPAS1 in Colorectal Cancer

(2014) Agnieszka Anna Rawłuszko-Wieczorek et al.   MOLECULAR CANCER RESEARCH

Hypoxia Promotes Dissemination and Colonization in New Bone Marrow Niches in Waldenström Macroglobulinemia

(2014) Barbara Muz et al.   MOLECULAR CANCER RESEARCH

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Angiogenesis and expression of PDGF-C, VEGF, CD105 and HIF-1α in human glioblastoma

(2014) Carlos Afonso Clara et al.   NEUROPATHOLOGY

Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes

(2014) M Aga et al.   ONCOGENE

Effects of the HIF-1α and NF-κB loop on epithelial-mesenchymal transition and chemoresistance induced by hypoxia in pancreatic cancer cells

(2014) ZHUO-XIN CHENG et al.   ONCOLOGY REPORTS

Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia

(2014) HAITAO ZHU et al.   ONCOLOGY REPORTS

The Role of the HIF-1α Transcription Factor in Increased Cell Division at Physiological Oxygen Tensions

(2014) Samantha Carrera et al.   PLoS One

Dormancy of Cancer Cells with Suppression of AKT Activity Contributes to Survival in Chronic Hypoxia

(2014) Hiroko Endo et al.   PLoS One

The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence

(2014) Mehtap Kilic Eren et al.   PLoS One

Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts

(2014) M. Ammirante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation

(2014) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

(2014) Erinn B. Rankin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis

(2014) Esak Lee et al.   Nature Communications

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

(2014) Anne-Theres Henze et al.   Nature Communications

PHD3 regulates EGFR internalization and signalling in tumours

(2014) Boyan K. Garvalov et al.   Nature Communications

HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs

(2014) Tao Zhao et al.   Scientific Reports

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia

(2014) Peng Zhang et al.   Cell Reports

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma

(2013) K. Y. Aguilera et al.   CANCER RESEARCH

Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

(2013) D. M. Gilkes et al.   CANCER RESEARCH

HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression

(2013) Chen-Ye Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells

(2013) Dhivya R. Sudhan et al.   CLINICAL & EXPERIMENTAL METASTASIS

A 26-Gene Hypoxia Signature Predicts Benefit from Hypoxia-Modifying Therapy in Laryngeal Cancer but Not Bladder Cancer

(2013) A. Eustace et al.   CLINICAL CANCER RESEARCH

Oxygen-independent Regulation of HIF-1: Novel Involvement of PI3K/ AKT/mTOR Pathway in Cancer

(2013) Faton Agani et al.   CURRENT CANCER DRUG TARGETS

Targeting Hypoxia for Sensitization of Tumors to Radio- and Chemotherapy

(2013) Khaled Ghattass et al.   CURRENT CANCER DRUG TARGETS

Differentiated embryonic chondrocyte-expressed gene 1 is associated with hypoxia-inducible factor 1α and Ki67 in human gastric cancer

(2013) Yan-Fei Jia et al.   Diagnostic Pathology

Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation

(2013) Li Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Digoxin Downregulates NDRG1 and VEGF through the Inhibition of HIF-1α under Hypoxic Conditions in Human Lung Adenocarcinoma A549 Cells

(2013) Dong Wei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by InducingP4HA1, P4HA2,andPLOD2Expression in Fibroblasts

(2013) Daniele M. Gilkes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner

(2013) Jianjun Lei et al.   Molecular Cancer

Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis

(2013) Daniele M. Gilkes et al.   MOLECULAR CANCER RESEARCH

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

(2013) Thomas H Scheuermann et al.   Nature Chemical Biology

Tumor metastasis: moving new biological insights into the clinic

(2013) Liling Wan et al.   NATURE MEDICINE

HIF-1α Expression Correlates with Cellular Apoptosis, Angiogenesis and Clinical Prognosis in Rectal Carcinoma

(2013) Liu Feng et al.   PATHOLOGY & ONCOLOGY RESEARCH

Hypoxia Inducible Factor 3α Plays a Critical Role in Alveolarization and Distal Epithelial Cell Differentiation during Mouse Lung Development

(2013) Yadi Huang et al.   PLoS One

Insulin Regulates Hypoxia-Inducible Factor-1α Transcription by Reactive Oxygen Species Sensitive Activation of Sp1 in 3T3-L1 Preadipocyte

(2013) Sudipta Biswas et al.   PLoS One

Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis

(2013) T. S. K. Eisinger-Mathason et al.   Cancer Discovery

Moscatilin Inhibits Lung Cancer Cell Motility and Invasion via Suppression of Endogenous Reactive Oxygen Species

(2013) Akkarawut Kowitdamrong et al.   Biomed Research International

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

(2012) A. K. Azab et al.   BLOOD

HIF1  is required for survival maintenance of chronic myeloid leukemia stem cells

(2012) H. Zhang et al.   BLOOD

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

(2012) Vesselina G. Cooke et al.   CANCER CELL

Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity

(2012) Rodrigo Leite de Oliveira et al.   CANCER CELL

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

(2012) Cristina Branco-Price et al.   CANCER CELL

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

(2012) Jaclyn Sceneay et al.   CANCER RESEARCH

Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells

(2012) M. Z. Noman et al.   CANCER RESEARCH

Molecular Pathways: Emerging Pathways Mediating Growth, Invasion, and Metastasis of Tumors Progressing in an Irradiated Microenvironment

(2012) F. Kuonen et al.   CLINICAL CANCER RESEARCH

Inhibition of the Kit Ligand/c-Kit Axis Attenuates Metastasis in a Mouse Model Mimicking Local Breast Cancer Relapse after Radiotherapy

(2012) F. Kuonen et al.   CLINICAL CANCER RESEARCH

Imaging of Hypoxia Using PET and MRI

(2012) F. C. Gaertner et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

HIF-1α up-regulation is associated with adverse clinicopathological and biological factors in neuroblastomas

(2012) Josiah V Dungwa et al.   HISTOPATHOLOGY

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

(2012) Federica Maione et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

(2012) Carmen Chak-Lui Wong et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tumors exposed to acute cyclic hypoxia show increased vessel density and delayed blood supply

(2012) Jon-Vidar Gaustad et al.   MICROVASCULAR RESEARCH

New Insight into the SDF-1/CXCR4 Axis in a Breast Carcinoma Model: Hypoxia-Induced Endothelial SDF-1 and Tumor Cell CXCR4 Are Required for Tumor Cell Intravasation

(2012) F. Jin et al.   MOLECULAR CANCER RESEARCH

EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis

(2012) Weiwei Yang et al.   MOLECULAR CELL

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

(2012) Marco Montagner et al.   NATURE

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation

(2012) B K Nayak et al.   ONCOGENE

Expression and stability of hypoxia inducible factor 1α in osteosarcoma

(2012) Amal El Naggar et al.   PEDIATRIC BLOOD & CANCER

HIF1-Alpha Expression Predicts Survival of Patients with Squamous Cell Carcinoma of the Oral Cavity

(2012) Marcelo dos Santos et al.   PLoS One

Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

(2012) L. Schito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

(2012) O. V. Leontieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer stem cells and metastasis

(2012) Katia Sampieri et al.   SEMINARS IN CANCER BIOLOGY

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

18F-fluoromisonidazole positron emission tomography before treatment is a predictor of radiotherapy outcome and survival prognosis in patients with head and neck squamous cell carcinoma

(2011) Masahiro Kikuchi et al.   ANNALS OF NUCLEAR MEDICINE

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Evaluating rational non-cross-resistant combination therapy in advanced clear cell renal cell carcinoma: combined mTOR and AKT inhibitor therapy

(2011) William S. Holland et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Hypoxia-Associated Factor Switches Cells from HIF-1 - to HIF-2 -Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

(2011) M. Y. Koh et al.   CANCER RESEARCH

Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer

(2011) Q. Chang et al.   CANCER RESEARCH

Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression

(2011) M. Z. Noman et al.   CANCER RESEARCH

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

(2011) L Qiang et al.   CELL DEATH AND DIFFERENTIATION

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

(2011) Minna Heikkilä et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1  in Advanced Solid Tumors

(2011) S. Kummar et al.   CLINICAL CANCER RESEARCH

Antiangiogenic activity of berberine is mediated through the downregulation of hypoxia-inducible factor-1, VEGF, and proinflammatory mediators

(2011) T.P. Hamsa et al.   DRUG AND CHEMICAL TOXICOLOGY

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Microtubule disruption targets HIF-1α mRNA to cytoplasmic P-bodies for translational repression

(2011) Marisa Carbonaro et al.   JOURNAL OF CELL BIOLOGY

Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells

(2011) Christina D. Befani et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Metastatic Renal Cell Carcinoma: Relationship Between Initial Metastasis Hypoxia, Change After 1 Month's Sunitinib, and Therapeutic Response: An 18F-Fluoromisonidazole PET/CT Study

(2011) F. Hugonnet et al.   JOURNAL OF NUCLEAR MEDICINE

Mouse Snail Is a Target Gene for HIF

(2011) D. Luo et al.   MOLECULAR CANCER RESEARCH

Antiangiogenic therapy, hypoxia and metastasis: risky liaisons, or not?

(2011) Katrien De Bock et al.   Nature Reviews Clinical Oncology

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

(2011) H Zhang et al.   ONCOGENE

Nuclear Factor-κB–Dependent Epithelial to Mesenchymal Transition Induced by HIF-1α Activation in Pancreatic Cancer Cells under Hypoxic Conditions

(2011) Zhuo-Xin Cheng et al.   PLoS One

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

(2011) C. C.-L. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic and Functional Studies Implicate HIF1  as a 14q Kidney Cancer Suppressor Gene

(2011) C. Shen et al.   Cancer Discovery

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

Impaired pancreatic development in Hif2-alpha deficient mice

(2010) Huiping Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype

(2010) K Ameri et al.   BRITISH JOURNAL OF CANCER

Antitumor agent PX-12 inhibits HIF-1α protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferase

(2010) Yon Hui Kim et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1α

(2010) Sreenivasulu Chintala et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

In vivo Dynamics and Distinct Functions of Hypoxia in Primary Tumor Growth and Organotropic Metastasis of Breast Cancer

(2010) X. Lu et al.   CANCER RESEARCH

Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1  Expression in an AhR-Independent Fashion

(2010) E. Terzuoli et al.   CANCER RESEARCH

NF- B-Dependent Plasticity of the Epithelial to Mesenchymal Transition Induced by Von Hippel-Lindau Inactivation in Renal Cell Carcinomas

(2010) A. J. Pantuck et al.   CANCER RESEARCH

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2α

(2010) Michal Manisterski et al.   CELL CYCLE

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

(2010) Barbara Chiavarina et al.   CELL CYCLE

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer

(2010) Roberta Pang et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma

(2010) D. C. Cho et al.   CLINICAL CANCER RESEARCH

Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1α

(2010) Dazhong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Suppression of Bim and Bmf Blocks Anoikis and Luminal Clearing during Mammary Morphogenesis

(2010) Kelly A. Whelan et al.   MOLECULAR BIOLOGY OF THE CELL

Radiosensitization and Stromal Imaging Response Correlates for the HIF-1 Inhibitor PX-478 Given with or without Chemotherapy in Pancreatic Cancer

(2010) D. L. Schwartz et al.   MOLECULAR CANCER THERAPEUTICS

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

(2010) Hakan Cam et al.   MOLECULAR CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1α in non-small cell lung cancer cells

(2010) L Xu et al.   ONCOGENE

Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity

(2010) Hsieh   ONCOLOGY REPORTS

Intermittent Hypoxia-Mediated Plasticity of Acute O2 Sensing Requires Altered Red-Ox Regulation by HIF-1 and HIF-2

(2009) Nanduri R. Prabhakar et al.   Annals of the New York Academy of Sciences

The Role of NF-κB in Hypoxia-Induced Gene Expression

(2009) Cormac T. Taylor et al.   Annals of the New York Academy of Sciences

The humanHIF(hypoxia-inducible factor)-3α gene is a HIF-1 target gene and may modulate hypoxic gene induction

(2009) Tetsuhiro Tanaka et al.   BIOCHEMICAL JOURNAL

Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy

(2009) H Harada et al.   BRITISH JOURNAL OF CANCER

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

(2009) J Chen et al.   BRITISH JOURNAL OF CANCER

Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment

(2009) Denise A. Chan et al.   CANCER CELL

Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase

(2009) Qing Zhang et al.   CANCER CELL

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α

(2009) Woo-Young Kim et al.   CANCER RESEARCH

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress

(2009) Seong-Hee Lee et al.   CARCINOGENESIS

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

HIF-1  and HIF-2  Are Differentially Regulated In vivo in Neuroblastoma: High HIF-1  Correlates Negatively to Advanced Clinical Stage and Tumor Vascularization

(2009) R. Noguera et al.   CLINICAL CANCER RESEARCH

An Akt/Hypoxia-Inducible Factor-1 /Platelet-Derived Growth Factor-BB Autocrine Loop Mediates Hypoxia-Induced Chemoresistance in Liver Cancer Cells and Tumorigenic Hepatic Progenitor Cells

(2009) C. K. Lau et al.   CLINICAL CANCER RESEARCH

The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia

(2009) Ruth Schietke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial NOS, estrogen receptor β, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer

(2009) Simona Nanni et al.   JOURNAL OF CLINICAL INVESTIGATION

The Cooperative Induction of Hypoxia-Inducible Factor-1  and STAT3 during Hypoxia Induced an Impairment of Tumor Susceptibility to CTL-Mediated Cell Lysis

(2009) M. Z. Noman et al.   JOURNAL OF IMMUNOLOGY

G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth

(2009) Yongli Guan et al.   MOLECULAR THERAPY

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

(2009) Yair Benita et al.   NUCLEIC ACIDS RESEARCH

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

The Aryl Hydrocarbon Nuclear Translocator Alters CD30-Mediated NF- B-Dependent Transcription

(2009) C. W. Wright et al.   SCIENCE

Regulation of hypoxia-inducible factor-1α by NF-κB

(2008) Patrick van Uden et al.   BIOCHEMICAL JOURNAL

Hypoxia-Inducible Factor 1  Mediates Anoikis Resistance via Suppression of  5 Integrin

(2008) N. Rohwer et al.   CANCER RESEARCH

Hypoxia-Inducible Factor-2  Correlates to Distant Recurrence and Poor Outcome in Invasive Breast Cancer

(2008) K. Helczynska et al.   CANCER RESEARCH

CYR61 and  V 5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma

(2008) Y. Monnier et al.   CANCER RESEARCH

Impact of cyclic hypoxia on HIF-1α regulation in endothelial cells - new insights for anti-tumor treatments

(2008) Philippe Martinive et al.   FEBS Journal

High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability

(2008) Alysha K. Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1 , Leading to Its Oxygen-Independent Degradation

(2008) M. Y. Koh et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1 

(2008) M. Y. Koh et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity

(2008) R. Sullivan et al.   MOLECULAR CANCER THERAPEUTICS

A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth

(2008) L. M. Greenberger et al.   MOLECULAR CANCER THERAPEUTICS

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

PCAF is an HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia

(2008) G Xenaki et al.   ONCOGENE

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia Enhances Tumor Stemness by Increasing the Invasive and Tumorigenic Side Population Fraction

(2008) Bikul Das et al.   STEM CELLS