Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 115, Issue 26, Pages E5990-E5999
Publisher
Proceedings of the National Academy of Sciences
Online
2018-06-12
DOI
10.1073/pnas.1801348115
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
- (2018) Shicheng Su et al. CELL
- CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer
- (2016) Piero Dalerba et al. NEW ENGLAND JOURNAL OF MEDICINE
- Hedgehog signaling in colorectal cancer: a spiny issue gets smoothened
- (2016) Melania Scarpa et al. Translational Cancer Research
- High SLFN11 expression predicts better survival for patients with KRAS exon 2 wild type colorectal cancer after treated with adjuvant oxaliplatin-based treatment
- (2015) Yanhong Deng et al. BMC CANCER
- Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis
- (2015) Ganji Purnachandra Nagaraju et al. CANCER LETTERS
- The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
- (2015) Vicki Plaks et al. Cell Stem Cell
- Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
- (2015) Alexandre Calon et al. NATURE GENETICS
- Stromal contribution to the colorectal cancer transcriptome
- (2015) Claudio Isella et al. NATURE GENETICS
- The consensus molecular subtypes of colorectal cancer
- (2015) Justin Guinney et al. NATURE MEDICINE
- Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened
- (2015) Annelies Gonnissen et al. Oncotarget
- Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients
- (2015) Maria Serova et al. Oncotarget
- CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis
- (2014) Matilde Todaro et al. Cell Stem Cell
- TGF-beta in CAF-mediated tumor growth and metastasis
- (2014) A. Calon et al. SEMINARS IN CANCER BIOLOGY
- TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer
- (2013) Neil E. Bhola et al. JOURNAL OF CLINICAL INVESTIGATION
- Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
- (2013) Fiorenza Lotti et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
- (2013) Felipe De Sousa E Melo et al. NATURE MEDICINE
- A colorectal cancer classification system that associates cellular phenotype and responses to therapy
- (2013) Anguraj Sadanandam et al. NATURE MEDICINE
- Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
- (2012) Alexandre Calon et al. CANCER CELL
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- Embryonic NANOG Activity Defines Colorectal Cancer Stem Cells and Modulates through AP1- and TCF-dependent Mechanisms
- (2012) Elsayed E. Ibrahim et al. STEM CELLS
- The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse
- (2011) Anna Merlos-Suárez et al. Cell Stem Cell
- Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas
- (2010) Frédéric Varnat et al. EMBO Molecular Medicine
- Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
- (2010) Louis Vermeulen et al. NATURE CELL BIOLOGY
- How does PKMζ maintain long-term memory?
- (2010) Todd C. Sacktor NATURE REVIEWS NEUROSCIENCE
- Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy
- (2009) Susumu Saigusa et al. ANNALS OF SURGICAL ONCOLOGY
- Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications
- (2009) Dan Cao et al. BMC CANCER
- Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis
- (2009) S Rasheed et al. BRITISH JOURNAL OF CANCER
- Long-Term Survivors of Metastatic Colorectal Cancer Treated with Systemic Chemotherapy Alone: A North Central Cancer Treatment Group Review of 3811 Patients, N0144
- (2009) Grace K. Dy et al. Clinical Colorectal Cancer
- Experimentally Derived Metastasis Gene Expression Profile Predicts Recurrence and Death in Patients With Colon Cancer
- (2009) J. Joshua Smith et al. GASTROENTEROLOGY
- Recent advances in cancer stem cells
- (2008) Robert W Cho et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started