Nrf2 at the heart of oxidative stress and cardiac protection

Mangiferin antagonizes TNF-α-mediated inflammatory reaction and protects against dermatitis in a mice model

(2017) Yunpeng Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The adverse impact of obesity on heart rate variability is modified by a NFE2L2 gene variant: The SAPALDIA cohort

(2017) Martin Adam et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex

(2017) Shasha Tao et al.   MOLECULAR AND CELLULAR BIOLOGY

Methylmercury augments Nrf2 activity by downregulation of the Src family kinase Fyn

(2017) Megan Culbreth et al.   NEUROTOXICOLOGY

Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway

(2017) Jialin Duan et al.   Scientific Reports

Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

(2017) Li Zhang et al.   Scientific Reports

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

(2017) Sharadha Dayalan Naidu et al.   Scientific Reports

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

(2016) Marta Pajares et al.   Autophagy

3-(2-Oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome

(2016) Yajing Wang et al.   BIOCHEMICAL PHARMACOLOGY

Bardoxolone methyl prevents the development and progression of cardiac and renal pathophysiologies in mice fed a high-fat diet

(2016) Danielle Camer et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Executive Summary: Heart Disease and Stroke Statistics—2016 Update

(2016) Dariush Mozaffarian et al.   CIRCULATION

Heme Oxygenase-1 and Carbon Monoxide in the Heart

(2016) Leo E. Otterbein et al.   CIRCULATION RESEARCH

Sodium Sulfide Attenuates Ischemic-Induced Heart Failure by Enhancing Proteasomal Function in an Nrf2-Dependent MannerCLINICAL PERSPECTIVE

(2016) Yuuki Shimizu et al.   Circulation-Heart Failure

Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury

(2016) Weimin Chen et al.   FASEB JOURNAL

Nrf2 protects mitochondrial decay by oxidative stress

(2016) Joshua Strom et al.   FASEB JOURNAL

Protein levels in Keap1-Nrf2 system in human failing heart

(2016) Masaaki Konishi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Genetic Polymorphisms of Transcription Factor NRF2 and of its Host Gene Sulfiredoxin (SRXN1) are Associated with Cerebrovascular Disease in a Finnish Cohort, the TAMRISK Study

(2016) Tarja Kunnas et al.   International Journal of Medical Sciences

Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway

(2016) TIANXIN HU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

(2016) Meng-Chen Lu et al.   MEDICINAL RESEARCH REVIEWS

G-Quadruplex in the NRF2 mRNA 5′ Untranslated Region Regulates De Novo NRF2 Protein Translation under Oxidative Stress

(2016) Sang C. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients

(2016) Angélica Saraí Jiménez-Osorio et al.   Oxidative Medicine and Cellular Longevity

NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis

(2016) Hui Wang et al.   Science Translational Medicine

Statins and myocardial infarction: Type, dose, and administration time: Does it matter?

(2016) Nikolaos Papageorgiou et al.   TRENDS IN CARDIOVASCULAR MEDICINE

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

(2016) Tetsuya Saito et al.   Nature Communications

NFE2L2 variations reduce antioxidant response in patients with Parkinson disease

(2016) YaXing Gui et al.   Oncotarget

Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice

(2016) Zheng Xu et al.   Scientific Reports

Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: Roles of Nrf2/HO-1 and PI3K/Akt pathway

(2016) Hua Li et al.   Scientific Reports

Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors

(2016) Sunhyo Kim et al.   Scientific Reports

A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair

(2016) Michèle Telorack et al.   PLoS Genetics

Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor‐Erythroid 2‐Related Factor 2 (Nrf2)‐Dependent Signaling in Chronic Heart Failure

(2016) Erminia Donnarumma et al.   Journal of the American Heart Association

The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation

(2016) Xiaobin Liu et al.   Redox Biology

GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion

(2016) Xi Chen et al.   Scientific Reports

Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

(2016) Shasha Tao et al.   Scientific Reports

A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response

(2015) Tao Shen et al.   ANTIOXIDANTS & REDOX SIGNALING

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

(2015) Ida Johansson et al.   Autophagy

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention

(2015) Bryan Harder et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Peptide and small molecule inhibitors of the Keap1–Nrf2 protein–protein interaction

(2015) Geoff Wells   BIOCHEMICAL SOCIETY TRANSACTIONS

Nrf2-Dependent Suppression of Azoxymethane/Dextran Sulfate Sodium-Induced Colon Carcinogenesis by the Cinnamon-Derived Dietary Factor Cinnamaldehyde

(2015) M. Long et al.   Cancer Prevention Research

Triptolide Attenuates Myocardial Ischemia/Reperfusion Injuries in Rats by Inducing the Activation of Nrf2/HO-1 Defense Pathway

(2015) Haijie Yu et al.   Cardiovascular Toxicology

Hrd1 and ER-Associated Protein Degradation, ERAD, Are Critical Elements of the Adaptive ER Stress Response in Cardiac MyocytesNovelty and Significance

(2015) Shirin Doroudgar et al.   CIRCULATION RESEARCH

An Essential Role of NRF2 in Diabetic Wound Healing

(2015) Min Long et al.   DIABETES

Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease

(2015) Nosratola D. Vaziri et al.   FREE RADICAL BIOLOGY AND MEDICINE

The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1

(2015) Sue Goo Rhee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2

(2015) Shasha Tao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1

(2015) Haobo Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural basis of Keap1 interactions with Nrf2

(2015) Peter Canning et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy

(2015) Chen Qu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2

(2015) Hui Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo

(2015) Chunlai Zeng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway

(2015) Guoguo Shang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways

(2015) Musen Lin et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Potential drugs which activate nuclear factor E2-related factor 2 signaling to prevent diabetic cardiovascular complications: A focus on fumaric acid esters

(2015) Shanshan Zhou et al.   LIFE SCIENCES

Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice

(2015) Andiara E. Freitas et al.   MOLECULAR NEUROBIOLOGY

Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation

(2015) Yang Bai et al.   Oxidative Medicine and Cellular Longevity

The Triterpenoid RTA 408 is a Robust Mitigator of Hematopoietic Acute Radiation Syndrome in Mice

(2015) Devorah C. Goldman et al.   RADIATION RESEARCH

Novel curcumin analogue 14p protects against myocardial ischemia reperfusion injury through Nrf2-activating anti-oxidative activity

(2015) Weixin Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

(2015) Sharadha Dayalan Naidu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer

(2015) Tatsuhiro Shibata et al.   NEOPLASIA

Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl

(2014) Melanie P. Chin et al.   AMERICAN JOURNAL OF NEPHROLOGY

Myocardial ischemic reperfusion induces de novo Nrf2 protein translation

(2014) Beibei Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nrf2 Deficiency Impairs Fracture Healing in Mice

(2014) Sebastian Lippross et al.   CALCIFIED TISSUE INTERNATIONAL

Coronary Artery Disease and Diabetes Mellitus

(2014) Doron Aronson et al.   CARDIOLOGY CLINICS

Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo

(2014) Huadong Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease

(2014) S. M. Tan et al.   DIABETES

The paradox of bardoxolone methyl: a call for every witness on the stand?

(2014) S. Van Laecke et al.   DIABETES OBESITY & METABOLISM

Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress

(2014) Wenjuan Li et al.   FEBS LETTERS

Antiarrhythmic effect of lithium in rats after myocardial infarction by activation of Nrf2/HO-1 signaling

(2014) Tsung-Ming Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

(2014) T. Wu et al.   GENES & DEVELOPMENT

Polymorphism of Nrf2, an Antioxidative Gene, is Associated with Blood Pressure and Cardiovascular Mortality in Hemodialysis Patients

(2014) Yasuhiko Shimoyama et al.   International Journal of Medical Sciences

Mangiferin increases Nrf2 protein stability by inhibiting its ubiquitination and degradation in human HL60 myeloid leukemia cells

(2014) JIE ZHAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk Factors for Heart Failure in Patients With Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated With Bardoxolone Methyl

(2014) Melanie P. Chin et al.   JOURNAL OF CARDIAC FAILURE

Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation

(2014) Yang Yang et al.   Molecular Cancer

Bardoxolone Methyl in Type 2 Diabetes and Advanced Chronic Kidney Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

NFE2L2 polymorphisms, mortality, and metabolism in the general population

(2014) Sylwia M. Figarska et al.   PHYSIOLOGICAL GENOMICS

SPBP Is a Sulforaphane Induced Transcriptional Coactivator of NRF2 Regulating Expression of the Autophagy Receptor p62/SQSTM1

(2014) Sagar Ramesh Darvekar et al.   PLoS One

Nrf2-Inducing Anti-Oxidation Stress Response in the Rat Liver - New Beneficial Effect of Lansoprazole

(2014) Yasunobu Yamashita et al.   PLoS One

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52

(2014) Chulman Jo et al.   Nature Communications

Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties

(2014) Shu-Feng Zhou et al.   Drug Design Development and Therapy

Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro

(2013) Ben-ping Zhang et al.   ACTA PHARMACOLOGICA SINICA

Encouraging Trends in Acute Myocardial Infarction Survival in the Oldest Old

(2013) Jennifer Tjia et al.   AMERICAN JOURNAL OF MEDICINE

Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner

(2013) Bridgette F. Peake et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tanshinone I Activates the Nrf2-Dependent Antioxidant Response and Protects Against As(III)-Induced Lung Inflammation In Vitro and In Vivo

(2013) Shasha Tao et al.   ANTIOXIDANTS & REDOX SIGNALING

The absence of macrophage Nrf2 promotes early atherogenesis

(2013) Anna-Kaisa Ruotsalainen et al.   CARDIOVASCULAR RESEARCH

Heart Disease and Stroke Statistics—2014 Update

(2013) Alan S. Go et al.   CIRCULATION

The role of the Nrf2-mediated defense system in corneal epithelial wound healing

(2013) Ryuhei Hayashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lactulose ameliorates cerebral ischemia–reperfusion injury in ratsby inducing hydrogen by activating Nrf2 expression

(2013) Xiao Zhai et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Endogenous Prostaglandin D 2 and Its Metabolites Protect the Heart Against Ischemia–Reperfusion Injury by Activating Nrf2

(2013) Yoshinori Katsumata et al.   HYPERTENSION

Peri-Infarct Zone Characterized by Cardiac Magnetic Resonance Imaging is Directly Associated with the Inflammatory Activity During Acute Phase Myocardial Infarction

(2013) Jose C. Quinaglia e Silva et al.   INFLAMMATION

Knockdown of Nrf2 Inhibits the Angiogenesis of Rat Cardiac Micro-vascular Endothelial Cells under Hypoxic Conditions

(2013) Lihong Kuang et al.   International Journal of Biological Sciences

Genotype analysis of the NRF2 gene mutation in lung cancer

(2013) HIDEFUMI SASAKI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

3-Aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as Potent Nrf2/ARE Inducers in Human Cancer Cells and AOM-DSS Treated Mice

(2013) Mei-yang Xi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

(2013) Yang Bai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats

(2013) E. Mitchell Seymour et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response

(2013) Tao Jiang et al.   KIDNEY INTERNATIONAL

Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling

(2013) N. Wakabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

(2013) Hemant Kumar et al.   NATURAL PRODUCT REPORTS

New Therapies for Diabetic Kidney Disease

(2013) Jonathan Himmelfarb et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2

(2013) Hye-Youn Cho   Oxidative Medicine and Cellular Longevity

α-Lipoic Acid Reduces Infarct Size and Preserves Cardiac Function in Rat Myocardial Ischemia/Reperfusion Injury through Activation of PI3K/Akt/Nrf2 Pathway

(2013) Chao Deng et al.   PLoS One

Carvedilol Treatment After Myocardial Infarct Decreases Cardiomyocytic Apoptosis in the Peri-infarct Zone During Cardioplegia-Induced Cardiac Arrest

(2013) Chi-Hsiao Yeh et al.   SHOCK

Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes

(2013) Ji Hye Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

(2013) Shasha Tao et al.   Redox Biology

Aging, Diabetes, and the Public Health System in the United States

(2012) Carl J. Caspersen et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Bardoxolone Brings Nrf2-Based Therapies to Light

(2012) Donna D. Zhang   ANTIOXIDANTS & REDOX SIGNALING

l-Arginine ameliorates cardiac left ventricular oxidative stress by upregulating eNOS and Nrf2 target genes in alloxan-induced hyperglycemic rats

(2012) Tharmarajan Ramprasath et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Allicin Ameliorates Cardiac Hypertrophy and Fibrosis through Enhancing of Nrf2 Antioxidant Signaling Pathways

(2012) Xian-Hui Li et al.   CARDIOVASCULAR DRUGS AND THERAPY

Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

(2012) Houman Ashrafian et al.   Cell Metabolism

Discovery of Potent, Novel Nrf2 Inducers Via Quantum Modeling, Virtual Screening, andIn VitroExperimental Validation

(2012) Tracy P. Williamson et al.   Chemical Biology & Drug Design

Broccoli sprouts powder could improve serum triglyceride and oxidized LDL/LDL-cholesterol ratio in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial

(2012) Zahra Bahadoran et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Effect of statins on ventricular tachyarrhythmia, cardiac arrest, and sudden cardiac death: a meta-analysis of published and unpublished evidence from randomized trials

(2012) K. Rahimi et al.   EUROPEAN HEART JOURNAL

Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice

(2012) Janhavi Athale et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial

(2012) Zahra Bahadoran et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Increased NRF2 gene (NFE2L2) copy number correlates with mutations in lung squamous cell carcinomas

(2012) HIDEFUMI SASAKI et al.   Molecular Medicine Reports

Microarray and pathway analysis highlight Nrf2/ARE-mediated expression profiling by polyphenolic myricetin

(2012) Si Qin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge

(2012) Elise L. Donovan et al.   Oxidative Medicine and Cellular Longevity

Triterpenoid Dihydro-CDDO-Trifluoroethyl Amide Protects against Maladaptive Cardiac Remodeling and Dysfunction in Mice: A Critical Role of Nrf2

(2012) Yifan Xing et al.   PLoS One

Histone Deacetylase 6 Associates With Ribosomes and Regulates De Novo Protein Translation During Arsenite Stress

(2012) Kyle V. Kappeler et al.   TOXICOLOGICAL SCIENCES

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

(2012) Yoichiro Mitsuishi et al.   Frontiers in Oncology

A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes

(2011) Milad S. Bitar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones

(2011) David Siegel et al.   BIOCHEMICAL PHARMACOLOGY

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Up-regulation of p27kip1 contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy

(2011) Jinqing Li et al.   CARDIOVASCULAR RESEARCH

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

(2011) Stefan Freigang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oltipraz therapy in patients with liver fibrosis or cirrhosis: a randomized, double-blind, placebo-controlled phase II trial

(2011) Sang Geon Kim et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

La Autoantigen Mediates Oxidant Induced De Novo Nrf2 Protein Translation

(2011) Jack Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion

(2011) Koen Raedschelders et al.   PHARMACOLOGY & THERAPEUTICS

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

(2010) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial Nrf2 activation: a new target for resveratrol?

(2010) György Haskó et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

(2010) Albena T. Dinkova-Kostova et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection

(2010) Berenice Barajas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification and Characterization of Novel Nrf2 Inducers Designed to Target the Intervening Region of Keap1

(2010) Jian H. Wu et al.   Chemical Biology & Drug Design

A Small-Molecule Inducer of the Antioxidant Response Element

(2010) Wooyoung Hur et al.   CHEMISTRY & BIOLOGY

Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice

(2010) Z. Yu et al.   DIABETOLOGIA

Peri-procedural myocardial injury during percutaneous coronary intervention: an important target for cardioprotection

(2010) G. Ganesha Babu et al.   EUROPEAN HEART JOURNAL

Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression

(2010) Yong Pil Hwang et al.   FOOD AND CHEMICAL TOXICOLOGY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

4-Hydroxy-2-nonenal protects against cardiac ischemia–reperfusion injury via the Nrf2-dependent pathway

(2010) Yan Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NFE2L2 Gene Mutation in Male Japanese Squamous Cell Carcinoma of the Lung

(2010) Hidefumi Sasaki et al.   Journal of Thoracic Oncology

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial

(2010) Ory Keynan et al.   PAIN MEDICINE

Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

(2010) Curtis D. Klaassen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PYDDT, a novel phase 2 enzymes inducer, activates Keap1–Nrf2 pathway via depleting the cellular level of glutathione

(2010) Xiaoyu Zhang et al.   TOXICOLOGY LETTERS

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State

(2009) Mustafa Zakkar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

(2009) Chenhui Yang et al.   BRAIN RESEARCH

Prospective, Comprehensive Assessment of Cardiac Troponin T Testing After Coronary Artery Bypass Graft Surgery

(2009) Asim A. Mohammed et al.   CIRCULATION

Troponin is superior to electrocardiogram and creatinine kinase MB for predicting clinically significant myocardial injury after coronary artery bypass grafting

(2009) Jochen D. Muehlschlegel et al.   EUROPEAN HEART JOURNAL

Targeting the Nrf2 pathway against cardiovascular disease

(2009) Jinqing Li et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An internal ribosomal entry site mediates redox-sensitive translation of Nrf2

(2009) Wenge Li et al.   NUCLEIC ACIDS RESEARCH

Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial KATP channels

(2009) Cheng Shi Piao et al.   PHARMACOLOGICAL RESEARCH

Dihydro-CDDO-Trifluoroethyl Amide (dh404), a Novel Nrf2 Activator, Suppresses Oxidative Stress in Cardiomyocytes

(2009) Tomonaga Ichikawa et al.   PLoS One

Nrf2 protects against airway disorders

(2009) Hye-Youn Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

Human HRD1 Promoter Carries a Functional Unfolded Protein Response Element to Which XBP1 but not ATF6 Directly Binds

(2008) K. Yamamoto et al.   JOURNAL OF BIOCHEMISTRY

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

(2008) Xiaoqing He et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

(2008) Ana I. Rojo et al.   JOURNAL OF NEUROCHEMISTRY

Declining In-Hospital Mortality and Increasing Heart Failure Incidence in Elderly Patients With First Myocardial Infarction

(2008) Justin A. Ezekowitz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis

(2008) Weihua Xu et al.   LABORATORY INVESTIGATION

Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

(2008) Thomas E. Sussan et al.   PLoS One

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

(2007) Aruna Kode et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Protective Interventions to Prevent Aflatoxin-Induced Carcinogenesis in Developing Countries

(2007) John D. Groopman et al.   Annual Review of Public Health