The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

Thermodynamic profiling of inhibitors of Nrf2:Keap1 interactions

(2016) Hamid R. Nasiri et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer

(2015) Michael J. Bollong et al.   ACS Chemical Biology

Peptide and small molecule inhibitors of the Keap1–Nrf2 protein–protein interaction

(2015) Geoff Wells   BIOCHEMICAL SOCIETY TRANSACTIONS

Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway

(2015) B.G. Richardson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators

(2015) Atul D. Jain et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2

(2015) Adedamola Olayanju et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice

(2015) Tong Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Keap1–Nrf2 signalling in pancreatic cancer

(2015) Alastair J. Hayes et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor

(2015) Xia Wen et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling

(2015) Angelika F. Winkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Dynamic Characterization of Mutated Keap1 for Varied Affinity toward Nrf2: A Molecular Dynamics Simulation Study

(2015) I-Chung Cheng et al.   Journal of Chemical Information and Modeling

New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase

(2015) Wei Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor

(2015) Zheng-Yu Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction

(2015) Hélène C. Bertrand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure–Activity Relationship Study

(2015) Li-Li Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney

(2015) Luke M. Shelton et al.   KIDNEY INTERNATIONAL

Reviving the promise of transcription factor Nrf2-based therapeutics for kidney diseases

(2015) Sanjeev Noel et al.   KIDNEY INTERNATIONAL

Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis

(2015) Steffan Vartanian et al.   MOLECULAR & CELLULAR PROTEOMICS

The emerging role of redox-sensitive Nrf2–Keap1 pathway in diabetes

(2015) Elango Bhakkiyalakshmi et al.   PHARMACOLOGICAL RESEARCH

Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation

(2015) Mikiya Satoh et al.   FEBS Open Bio

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

(2015) Dhulfiqar Ali Abed et al.   Acta Pharmaceutica Sinica B

Synthesis and Biological Evaluation of Novel IM3829 (4-(2-Cyclohexylethoxy)aniline) Derivatives as Potent Radiosensitizers

(2015) Jiyeon Ahn et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Cullin3 - BTB Interface: A Novel Target for Stapled Peptides

(2015) Ivan de Paola et al.   PLoS One

Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms

(2014) Si Qin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Diabetes, oxidative stress and therapeutic strategies

(2014) Luc Rochette et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Monitoring Keap1–Nrf2 interactions in single live cells

(2014) Liam Baird et al.   BIOTECHNOLOGY ADVANCES

Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex

(2014) Eric Jnoff et al.   ChemMedChem

Updated Research and Applications of Small Molecule Inhibitors of Keap1-Nrf2 Protein-Protein Interaction: a Review

(2014) Chunlin Zhuang et al.   CURRENT MEDICINAL CHEMISTRY

Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease

(2014) S. M. Tan et al.   DIABETES

Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis

(2014) Zheng-Yu Jiang et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Rapid Identification of Keap1–Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search

(2014) Chunlin Zhuang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

(2014) Zheng-Yu Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO

(2014) Anne Cleasby et al.   PLoS One

A Review of the Evidence that Ochratoxin A Is an Nrf2 Inhibitor: Implications for Nephrotoxicity and Renal Carcinogenicity

(2014) Alice Limonciel et al.   Toxins

Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments

(2013) Stefan Hörer et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

The Extinguished BEACON of Bardoxolone: Not a Monday Morning Quarterback Story

(2013) John A. Tayek et al.   AMERICAN JOURNAL OF NEPHROLOGY

Diffusion dynamics of the Keap1–Cullin3 interaction in single live cells

(2013) Liam Baird et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

(2013) Douglas Marcotte et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

(2013) Longqin Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy

(2013) Alexander J. Gill et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Discovery of a Potential Anti-Inflammatory Agent: 3-Oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile

(2013) Ran You et al.   JOURNAL OF MEDICINAL CHEMISTRY

Keap Calm, and Carry on Covalently

(2013) Anthony J. Wilson et al.   JOURNAL OF MEDICINAL CHEMISTRY

3-Aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as Potent Nrf2/ARE Inducers in Human Cancer Cells and AOM-DSS Treated Mice

(2013) Mei-yang Xi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insight into the Intermolecular Recognition Mechanism between Keap1 and IKKβ Combining Homology Modelling, Protein-Protein Docking, Molecular Dynamics Simulations and Virtual Alanine Mutation

(2013) Zheng-Yu Jiang et al.   PLoS One

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

(2013) L. Baird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NQO1rs1800566 C>T polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population

(2013) Jun Yin et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Novel protein–protein interaction inhibitor of Nrf2–Keap1 discovered by structure-based virtual screening

(2013) Hao-Peng Sun et al.   MedChemComm

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL

(2012) Hui Tian et al.   CANCER LETTERS

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

(2012) J. Xu et al.   DIABETES

The transcription factor NF-E2-related Factor 2 (Nrf2): a protooncogene?

(2012) Phillip Shelton et al.   FASEB JOURNAL

An effective strategy for increasing the radiosensitivity of Human lung Cancer cells by blocking Nrf2-dependent antioxidant responses

(2012) Saelooom Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation

(2012) Nobuhiko Harada et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents

(2012) Suqing Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney

(2012) S. A. Reisman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

(2012) Iana M Serafimova et al.   Nature Chemical Biology

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats

(2012) Pankaj K. Bagul et al.   PHARMACOLOGICAL RESEARCH

Topical Application of Ochratoxin A Causes DNA Damage and Tumor Initiation in Mouse Skin

(2012) Rahul Kumar et al.   PLoS One

Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction

(2012) Richard Steel et al.   ACS Medicinal Chemistry Letters

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

(2012) Yoichiro Mitsuishi et al.   Frontiers in Oncology

Effect of Bardoxolone Methyl on Kidney Function in Patients with T2D and Stage 3b–4 CKD

(2011) Pablo E. Pergola et al.   AMERICAN JOURNAL OF NEPHROLOGY

A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes

(2011) Milad S. Bitar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

(2011) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Conditional Deletion ofNrf2in Airway Epithelium Exacerbates Acute Lung Injury and Impairs the Resolution of Inflammation

(2011) Narsa M. Reddy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Kinetic Analyses of Keap1-Nrf2 Interaction and Determination of the Minimal Nrf2 Peptide Sequence Required for Keap1 Binding Using Surface Plasmon Resonance

(2011) Yu Chen et al.   Chemical Biology & Drug Design

Natural Product Inhibitors of the Ubiquitin-Proteasome Pathway

(2011) John S. Schneekloth et al.   CURRENT DRUG TARGETS

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

(2011) Stefan Freigang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs

(2011) Xiuwen Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis

(2011) Tomasz M. Stępkowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction

(2011) Rowena Hancock et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress

(2011) Michael B. Sporn et al.   JOURNAL OF NATURAL PRODUCTS

ROS Acts as a Double-Edged Sword in the Pathogenesis of Type 2 Diabetes Mellitus: Is Nrf2 a Potential Target for the Treatment?

(2011) X. Wang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Managing the challenge of chemically reactive metabolites in drug development

(2011) B. Kevin Park et al.   NATURE REVIEWS DRUG DISCOVERY

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

(2011) D. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease

(2011) A. Boutten et al.   TRENDS IN MOLECULAR MEDICINE

The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer

(2010) Donna D. Zhang   ANTIOXIDANTS & REDOX SIGNALING

Regulation of NF-E2-Related Factor 2 Signaling for Cancer Chemoprevention: Antioxidant Coupled with Antiinflammatory

(2010) Rong Hu et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

(2010) Ken Itoh et al.   ANTIOXIDANTS & REDOX SIGNALING

Impaired Redox Signaling and Antioxidant Gene Expression in Endothelial Cells in Diabetes: A Role for Mitochondria and the Nuclear Factor-E2-Related Factor 2-Kelch-Like ECH-Associated Protein 1 Defense Pathway

(2010) Xinghua Cheng et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction

(2010) David Adenuga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis

(2010) S K Niture et al.   CELL DEATH AND DIFFERENTIATION

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

Small molecule modulators of antioxidant response pathway

(2010) Wooyoung Hur et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Exceptionally Potent Inducer of Cytoprotective Enzymes

(2010) Albena T. Dinkova-Kostova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp90 Interaction with INrf2(Keap1) Mediates Stress-induced Nrf2 Activation

(2010) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression

(2010) Ute Boettler et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Nuclear Factor Erythroid 2-Related Factor 2 Deletion Impairs Glucose Tolerance and Exacerbates Hyperglycemia in Type 1 Diabetic Mice

(2010) L. M. Aleksunes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

(2010) T. Ogura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Triterpenoid CDDO-Imidazolide Confers Potent Protection against Hyperoxic Acute Lung Injury in Mice

(2009) Narsa M. Reddy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

(2009) Melinda S. Yates et al.   CARCINOGENESIS

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

Genetic Ablation of Nrf2 Enhances Susceptibility to Acute Lung Injury After Traumatic Brain Injury in Mice

(2009) Wei Jin et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

(2009) Suryakant K. Niture et al.   JOURNAL OF CELL SCIENCE

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

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(2009) Ralf-Harto Hubner et al.   MOLECULAR MEDICINE

Nrf2 protects against airway disorders

(2009) Hye-Youn Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

(2008) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Down-Regulated NF-E2–Related Factor 2 in Pulmonary Macrophages of Aged Smokers and Patients with Chronic Obstructive Pulmonary Disease

(2008) Masaru Suzuki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

(2008) Marcus J. Calkins et al.   ANTIOXIDANTS & REDOX SIGNALING

Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3

(2008) Girish Rachakonda et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Activation of NF-E2-Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease

(2008) M. Xue et al.   DIABETES

Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity

(2008) Stuart P. Weisberg et al.   ENDOCRINOLOGY

Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in cultured kidney tubulus cells

(2008) C. Boesch-Saadatmandi et al.   FOOD AND CHEMICAL TOXICOLOGY

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

(2008) Anju Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells

(2008) C. Boesch-Saadatmandi et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

(2008) Xiaoqing He et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

(2008) Katja Kanninen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

(2008) Thomas E. Sussan et al.   PLoS One

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

(2008) D Goven et al.   THORAX

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

(2007) Aruna Kode et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Idiosyncratic Drug Reactions: Past, Present, and Future

(2007) Jack Uetrecht   CHEMICAL RESEARCH IN TOXICOLOGY