Article
Chemistry, Multidisciplinary
Alberto J. Nunez-Selles, Lauro Nuevas-Paz, Gregorio Martinez-Sanchez
Summary: This study found that metal-mangiferin complexes have good antioxidant and protection against protein oxidative damage effects in the adjuvant therapies of neurodegenerative diseases, cancer, diabetes, and cardiovascular disorders. The coordination complexes of Se (IV) and Zn (II) with mangiferin showed significantly improved antioxidant/protective effects compared to isolated mangiferin.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Bani Ismail, Peramaiyan Rajendran, Hamad Mohammed AbuZahra, Vishnu Priya Veeraraghavan
Summary: The study evaluated the effects of Mangiferin on DOX-induced cytotoxicity in HUVECs and found that MGN significantly increased Nrf2 expression through upregulating the PI3K/AKT pathway, thereby reducing cell apoptosis induced by DOX.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Danjie Li, Xiaoling Hong, Feijie Zhao, Xinxin Ci, Songling Zhang
Summary: Nrf2 plays a crucial role in regulating gene transcription through the Keap1-Nrf2-ARE signaling pathway, protecting cells from oxidative stress and harmful substances. Inhibiting the Nrf2 pathway may reverse drug resistance in ovarian cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Rui Wang, Changming Zhao, Shuxia Jiang, Zhaohua Zhang, Chunmei Ban, Guiping Zheng, Yan Hou, Bingjin Jin, Yannan Shi, Xin Wu, Qiangqiang Zhao
Summary: This study provides a comprehensive overview of the application of nanoparticles in leukemia research, including diagnosis, treatment, and molecular mechanisms. It offers valuable references for researchers interested in nanoparticles-leukemia.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vy Ngo, Martin L. L. Duennwald
Summary: Oxidative stress is associated with major human diseases, and the transcription factor Nrf2 plays a key role in the antioxidant defense system and has been extensively studied in disease contexts.
Article
Biochemistry & Molecular Biology
Sarah Naguib, Jon R. Backstrom, Melanie Gil, David J. Calkins, Tonia S. Rex
Summary: Oxidative stress contributes to degeneration of retinal ganglion cells and their axons in glaucoma, but the NRF2-KEAP1-ARE antioxidant pathway is early activated, helping to slow neurodegeneration in glaucoma.
Review
Oncology
Atefeh Khodakarami, Sara Adibfar, Vahid Karpisheh, Shiva Abolhasani, Pooya Jalali, Hamed Mohammadi, Jamshid Gholizadeh Navashenaq, Mohammad Hojjat-Farsangi, Farhad Jadidi-Niaragh
Summary: NF-E2-related factor 2 (Nrf2) transcription factor has contradictory roles in cancer, it can act as a tumor suppressor or a proto-oncogene. Nrf2 regulates multiple cellular processes and plays a crucial role in cell survival. However, Nrf2 also protects cancer cells from apoptosis and promotes tumor growth and metastasis.
CANCER CELL INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Ying Xie, Sen-ling Feng, Fang He, Pei-Yu Yan, Xiao-Jun Yao, Xing-Xing Fan, Elaine Lai-Han Leung, Hua Zhou
Summary: This study investigates the potential of targeting the Nrf2 pathway to overcome acquired drug resistance and enhance the therapeutic effects of chemotherapy and molecular-targeted therapy. It demonstrates that upregulation of Nrf2 in Gefitinib-resistant and paclitaxel-resistant lung cancer cells is an important mechanism.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Somayyeh Ghareghomi, Mehran Habibi-Rezaei, Marzia Arese, Luciano Saso, Ali Akbar Moosavi-Movahedi
Summary: ROS play a crucial role in cellular processes, with Keap1-Nrf2 pathway acting as a master antioxidant mechanism. While activation of Nrf2 benefits cells in early stages by reducing ROS levels, hyperactivation can support the survival of healthy and cancer cells against oxidative stress and treatments. Understanding the dual role of Nrf2 in cancer cells can be important in cancer treatment strategies.
Article
Oncology
Xiaohua Lu, Thomas Efferth
Summary: Cancer treatment is a challenge due to drug resistance and chemotherapy side effects. Artemisinin-type compounds have shown potential for acute leukemia treatment with anti-angiogenic, anti-metastatic, and growth inhibitory effects. More potent and target-selective compounds based on ARS scaffold are needed for further development.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fatma J. Al-Saeedi
Summary: The study demonstrates that mangiferin can reduce oxidative stress-induced cell damage by activating the Nrf2 signaling pathway and decreasing intracellular reactive oxygen species levels.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ji-Min Lv, Mostafa Gouda, Xing-Qian Ye, Zhi-Peng Shao, Jian-Chu Chen
Summary: In this study, the protective effect of purified kiwi leaves PAs (PKLPs) on oxidative stress mechanisms in Caco-2 cells was investigated. The results demonstrated that PKLPs can reduce oxidative damage by regulating the Nrf2-ARE signaling pathway.
Review
Biochemistry & Molecular Biology
Waseem Chauhan, Rahima Zennadi
Summary: Sickle cell disease (SCD) is a genetic disease characterized by anemia, increased hemolysis, and vaso-occlusive crises. Current approved drugs for SCD have limited effectiveness, and curative therapies are not widely available due to cost and adverse effects. Increasing fetal hemoglobin (HbF) expression can alleviate SCD severity by inhibiting hemoglobin S (HbS) polymerization and reducing oxidative stress. The Keap-1-Nrf2 complex, a cytoprotective signaling pathway, may represent a better target for more effective treatment options in SCD.
Review
Biochemistry & Molecular Biology
Paolo Tucci, Roberta Lattanzi, Cinzia Severini, Luciano Saso
Summary: In this review, we present the scientific literature supporting the role of nuclear transcription factor-2 (Nrf2) in Huntington's disease (HD) and the potential prophylactic and therapeutic role of this compound.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Julia Katharina Charlotte Kress, Christina Jessen, Anita Hufnagel, Werner Schmitz, Thamara Nishida Xavier da Silva, Ancely Ferreira dos Santos, Laura Mosteo, Colin R. Goding, Jose Pedro Friedmann Angeli, Svenja Meierjohann
Summary: The redox regulator NRF2 is activated during oxidative and electrophilic stress and is involved in redox regulation, metabolism, tumor therapy resistance, and immune suppression. This study reveals a previously unrecognized link between the integrated stress response (ISR) and NRF2, mediated by the ISR effector ATF4. NRF2 supports ATF4-induced cells by increasing cystine uptake and upregulating thioredoxin-related genes. These findings highlight the importance of the NRF2 response in cellular resilience.