Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice

Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients

(2017) Iva Lukic et al.   NEUROPSYCHOBIOLOGY

Alterations in the Nrf2–Keap1 signaling pathway and its downstream target genes in rat brain under stress

(2015) Jelena Djordjevic et al.   BRAIN RESEARCH

Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring

(2015) Adi Zheng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Astrocyte Regulation of Synaptic Behavior

(2014) Nicola J. Allen   Annual Review of Cell and Developmental Biology

Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration

(2014) Vivian Binder Neis et al.   BEHAVIOURAL BRAIN RESEARCH

Aquaporin-4 Knockout Exacerbates Corticosterone-Induced Depression by Inhibiting Astrocyte Function and Hippocampal Neurogenesis

(2014) Hui Kong et al.   CNS Neuroscience & Therapeutics

Sub-chronic agmatine treatment modulates hippocampal neuroplasticity and cell survival signaling pathways in mice

(2014) Andiara E. Freitas et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Agmatine Induces Nrf2 and Protects Against Corticosterone Effects in Hippocampal Neuronal Cell Line

(2014) Andiara E. Freitas et al.   MOLECULAR NEUROBIOLOGY

Mental health: A world of depression

(2014) Kerri Smith   NATURE

Macrophages and depression – A misalliance or well-arranged marriage?

(2014) Adam Roman et al.   Pharmacological Reports

Glial degeneration as a model of depression

(2014) Maria Śmiałowska et al.   Pharmacological Reports

Folic acid prevents depressive-like behavior induced by chronic corticosterone treatment in mice

(2014) Priscila B. Rosa et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Astrocyte-Synapse Structural Plasticity

(2014) Yann Bernardinelli et al.   NEURAL PLASTICITY

Keap1-Nrf2 signaling pathway: Mechanisms of regulation and role in protection of cells against toxicity caused by xenobiotics and electrophiles

(2013) K. T. Turpaev   BIOCHEMISTRY-MOSCOW

From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders

(2013) Gerard Sanacora et al.   BIOLOGICAL PSYCHIATRY

Altered Glial Plasticity in Animal Models for Mood Disorders

(2013) Boldizsár Czéh et al.   CURRENT DRUG TARGETS

Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue

(2013) Grazyna Rajkowska et al.   CURRENT DRUG TARGETS

Agmatine: clinical applications after 100 years in translation

(2013) John E. Piletz et al.   DRUG DISCOVERY TODAY

Glucocorticoid actions on synapses, circuits, and behavior: Implications for the energetics of stress

(2013) Brent Myers et al.   FRONTIERS IN NEUROENDOCRINOLOGY

NMDA Receptors and the L-Arginine–Nitric Oxide–Cyclic Guanosine Monophosphate Pathway Are Implicated in the Antidepressant-Like Action of the Ethanolic Extract from Tabebuia avellanedae in Mice

(2013) Andiara E. Freitas et al.   JOURNAL OF MEDICINAL FOOD

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

Astrogliopathology

(2013) Alexei Verkhratsky et al.   NEUROSCIENTIST

Agmatine abolishes restraint stress-induced depressive-like behavior and hippocampal antioxidant imbalance in mice

(2013) Andiara E. Freitas et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Nrf2 participates in depressive disorders through an anti-inflammatory mechanism

(2013) María Dolores Martín-de-Saavedra et al.   PSYCHONEUROENDOCRINOLOGY

The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study

(2012) Baron Shopsin   ACTA NEUROPSYCHIATRICA

Fluoxetine modulates hippocampal cell signaling pathways implicated in neuroplasticity in olfactory bulbectomized mice

(2012) Andiara E. Freitas et al.   BEHAVIOURAL BRAIN RESEARCH

Antioxidants as Antidepressants

(2012) Giovanni Scapagnini et al.   CNS DRUGS

Antidepressant-like action of the bark ethanolic extract from Tabebuia avellanedae in the olfactory bulbectomized mice

(2012) Andiara E. Freitas et al.   JOURNAL OF ETHNOPHARMACOLOGY

How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans

(2012) Thomas Frodl et al.   NEUROBIOLOGY OF DISEASE

Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice

(2012) Yukio Ago et al.   NEUROPHARMACOLOGY

Oxidative/nitrosative stress and antidepressants: Targets for novel antidepressants

(2012) Seung-Yup Lee et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

(2012) Michael Maes et al.   INFLAMMOPHARMACOLOGY

The establishment of a sensitive method in determining different neurotransmitters simultaneously in rat brains by using liquid chromatography–electrospray tandem mass spectrometry

(2011) Kevin Y. Zhu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Development and validation of an ultra-high performance liquid chromatography–tandem mass-spectrometry (UHPLC–MS/MS) method for the simultaneous determination of neurotransmitters in rat brain samples

(2011) Roberto Romero González et al.   JOURNAL OF NEUROSCIENCE METHODS

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

Spatial learning-induced accumulation of agmatine and glutamate at hippocampal CA1 synaptic terminals

(2011) S. Seo et al.   NEUROSCIENCE

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

(2011) Brian Leonard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Nrf2-ARE Pathway

(2010) Jeffrey A. Johnson et al.   Annals of the New York Academy of Sciences

Reelin as a putative vulnerability factor for depression: Examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice

(2010) April L. Lussier et al.   NEUROPHARMACOLOGY

Association between Repeated Unpredictable Chronic Mild Stress (UCMS) Procedures with a High Fat Diet: A Model of Fluoxetine Resistance in Mice

(2010) Elsa Isingrini et al.   PLoS One

A simple role for BDNF in learning and memory?

(2010) Cunha   Frontiers in Molecular Neuroscience

Chronic and acute stress and the prediction of major depression in women

(2009) Constance Hammen et al.   DEPRESSION AND ANXIETY

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

Regulation of the Hypothalamic-Pituitary-Adrenal Axis

(2009) Anastasios Papadimitriou et al.   NEUROIMMUNOMODULATION

Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine

(2009) Brijesh G. Taksande et al.   NEUROPHARMACOLOGY

The effects of chronic glucocorticoid exposure on dendritic length, synapse numbers and glial volume in animal models: Implications for hippocampal volume reductions in depression

(2009) Despina A. Tata et al.   PHYSIOLOGY & BEHAVIOR

Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: Evidence for the involvement of the monoaminergic system

(2009) Andiara E. Freitas et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Determination of 5-Hydroxytryptamine, Norepinephrine, Dopamine and Their Metabolites in Rat Brain Tissue by LC–ESI–MS–MS

(2008) Fenli Su et al.   CHROMATOGRAPHIA

Exogenous agmatine has neuroprotective effects against restraint-induced structural changes in the rat brain

(2008) Meng-Yang Zhu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

The HPA axis in major depression: classical theories and new developments

(2008) Carmine M. Pariante et al.   TRENDS IN NEUROSCIENCES