Novel treatment strategies for chronic kidney disease: insights from the animal kingdom

Red meat intake in chronic kidney disease patients: Two sides of the coin

(2018) Denise Mafra et al.   NUTRITION

Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol

(2018) Iris Erlund et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metabolic Effects of Berries with Structurally Diverse Anthocyanins

(2017) John Overall et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A PGAM5–KEAP1–Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking

(2017) Gary B. O'Mealey et al.   JOURNAL OF CELL SCIENCE

Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis via induction of Nrf2 and suppression of NF-κB and MAPK signalling

(2017) Dinesh Thummuri et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver

(2017) Debora Nigro et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease

(2017) Badreldin H. Ali et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Dietary Protein Sources and Risk for Incident Chronic Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study

(2017) Bernhard Haring et al.   JOURNAL OF RENAL NUTRITION

Nonpharmacologic Strategies to Modulate Nuclear Factor Erythroid 2–related Factor 2 Pathway in Chronic Kidney Disease

(2017) Marta Esgalhado et al.   JOURNAL OF RENAL NUTRITION

Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression

(2017) Masahiro Nezu et al.   KIDNEY INTERNATIONAL

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

(2017) Adeera Levin et al.   LANCET

Learning of nature: The curious case of the naked mole rat

(2017) Francisco Alejandro Lagunas-Rangel et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

(2017) Nard Kubben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of epigenetics in renal ageing

(2017) Paul G. Shiels et al.   Nature Reviews Nephrology

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Seasonal variations in transition, mortality and kidney transplantation among patients with end-stage renal disease in the USA

(2017) Yoshitsugu Obi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Con: Mesoamerican nephropathy: is the problem dehydration or rehydration?

(2017) Vito M. Campese   NEPHROLOGY DIALYSIS TRANSPLANTATION

The link between phenotype and fatty acid metabolism in advanced chronic kidney disease

(2017) Dan-Qian Chen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pro: Heat stress as a potential etiology of Mesoamerican and Sri Lankan nephropathy: a late night consult with Sherlock Holmes

(2017) Richard J. Johnson   NEPHROLOGY DIALYSIS TRANSPLANTATION

Resistant starch as a novel dietary strategy to maintain kidney health in diabetes mellitus

(2017) Gar Yee Koh et al.   NUTRITION REVIEWS

Neoteny, Prolongation of Youth: From Naked Mole Rats to “Naked Apes” (Humans)

(2017) Vladimir P. Skulachev et al.   PHYSIOLOGICAL REVIEWS

Synchronous timing of food resources triggers bears to switch from salmon to berries

(2017) Stephanie M. Carlson   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

(2017) Thomas J. Park et al.   SCIENCE

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

(2017) Annika S. Axelsson et al.   Science Translational Medicine

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

Vegetarian Diet in Chronic Kidney Disease—A Friend or Foe

(2017) Anna Gluba-Brzózka et al.   Nutrients

A basal ursine bear (Protarctos abstrusus) from the Pliocene High Arctic reveals Eurasian affinities and a diet rich in fermentable sugars

(2017) Xiaoming Wang et al.   Scientific Reports

Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles

(2017) Sechang Oh et al.   Scientific Reports

DASH (Dietary Approaches to Stop Hypertension) Diet and Risk of Subsequent Kidney Disease

(2016) Casey M. Rebholz et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span

(2016) R. Scott McIsaac et al.   Annals of the New York Academy of Sciences

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

(2016) Michael H. Smolensky et al.   CHRONOBIOLOGY INTERNATIONAL

The FGF23 and Klotho system beyond mineral metabolism

(2016) Makoto Kuro-o   Clinical and Experimental Nephrology

Nutrients and ageing

(2016) Peter Stenvinkel et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Molecular basis of circadian rhythmicity in renal physiology and pathophysiology

(2016) Michelle L. Gumz   EXPERIMENTAL PHYSIOLOGY

Drivers of hibernation in the brown bear

(2016) A. L. Evans et al.   Frontiers in Zoology

Delphinidin Prevents Muscle Atrophy and Upregulates miR-23a Expression

(2016) Motoki Murata et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells

(2016) Giuseppe Maltese et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Life in the fat lane: seasonal regulation of insulin sensitivity, food intake, and adipose biology in brown bears

(2016) K. S. Rigano et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Blood clotting behavior is innately modulated inUrsus americanusduring early and late denning relative to summer months

(2016) Tinen L. Iles et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Red Meat Intake and Risk of ESRD

(2016) Quan-Lan Jasmine Lew et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Is Dietary Red Meat Kidney Toxic?

(2016) Nimrit Goraya et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid

(2016) Frederico Alisson-Silva et al.   MOLECULAR ASPECTS OF MEDICINE

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

Cellular senescence in renal ageing and disease

(2016) Ines Sturmlechner et al.   Nature Reviews Nephrology

Eye lens radiocarbon reveals centuries of longevity in the Greenland shark (Somniosus microcephalus)

(2016) J. Nielsen et al.   SCIENCE

Chronic Kidney Disease in Aged Cats

(2016) C. A. Brown et al.   VETERINARY PATHOLOGY

The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos

(2016) Felix Sommer et al.   Cell Reports

Exploring principles of hibernation for organ preservation

(2016) Emmett D. Ratigan et al.   Transplantation Reviews

Delphinidin-Rich Maqui Berry Extract (Delphinol®) Lowers Fasting and Postprandial Glycemia and Insulinemia in Prediabetic Individuals during Oral Glucose Tolerance Tests

(2016) Jorge L. Alvarado et al.   Biomed Research International

Low sulfide levels and a high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat

(2016) Maja Dziegelewska et al.   Redox Biology

Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease

(2016) Catharina Missailidis et al.   PLoS One

Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats

(2016) Wenyan Sun et al.   Scientific Reports

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Contrary seasonal changes of rates of nutrient uptake, organ mass, and voluntary food intake in red deer (Cervus elaphus)

(2015) Walter Arnold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity

(2015) Judy C. Triplett et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The effect of vegetarian diet on skin autofluorescence measurements in haemodialysis patients

(2015) Arkom Nongnuch et al.   BRITISH JOURNAL OF NUTRITION

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

(2015) Christopher Hine et al.   CELL

Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease

(2015) Nosratola D. Vaziri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rapidly elevated levels of PGC-1α-b protein in human skeletal muscle after exercise: exploring regulatory factors in a randomized controlled trial

(2015) Eva-karin Gidlund et al.   JOURNAL OF APPLIED PHYSIOLOGY

The AMPK Agonist PT1 and mTOR Inhibitor 3HOI-BA-01 Protect Cardiomyocytes After Ischemia Through Induction of Autophagy

(2015) Ling Huang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria

(2015) Ken Itoh et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Suppressed bone remodeling in black bears conserves energy and bone mass during hibernation

(2015) M. McGee-Lawrence et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Relationship Between Oxidative Stress and Bone Mass in Obesity and Effects of Berry Supplementation on Bone Remodeling in Obese Male Mice: An Exploratory Study

(2015) Sang Gil Lee et al.   JOURNAL OF MEDICINAL FOOD

Systemic inflammation and oxidative stress in hemodialysis patients are associated with down-regulation of Nrf2

(2015) Liliana M. Pedruzzi et al.   JOURNAL OF NEPHROLOGY

Reviving the promise of transcription factor Nrf2-based therapeutics for kidney diseases

(2015) Sanjeev Noel et al.   KIDNEY INTERNATIONAL

Hyperphosphatemia induces cellular senescence in human aorta smooth muscle cells through integrin linked kinase (ILK) up-regulation

(2015) Nuria Troyano et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

(2015) John L. Wallace et al.   NATURE REVIEWS DRUG DISCOVERY

Ecophysiology of Omega Fatty Acids: A Lid for Every Jar

(2015) Walter Arnold et al.   PHYSIOLOGY

Pathology in Captive Wild Felids at German Zoological Gardens

(2015) Johannes Junginger et al.   PLoS One

Balancing Nutrition and Serum Phosphorus in Maintenance Dialysis

(2014) Denis Fouque et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat

(2014) Kelly M. Grimes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phosphate Binders Prevent Phosphate-Induced Cellular Senescence of Vascular Smooth Muscle Cells and Vascular Calcification in a Modified, Adenine-Based Uremic Rat Model

(2014) S. Yamada et al.   CALCIFIED TISSUE INTERNATIONAL

γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L -Carnitine to TMAO

(2014) Robert A. Koeth et al.   Cell Metabolism

A review of the biology of calcium phosphate sequestration with special reference to milk

(2014) Samuel Lenton et al.   Dairy Science & Technology

Maintaining skeletal muscle mass: lessons learned from hibernation

(2014) Evgueni A. Ivakine et al.   EXPERIMENTAL PHYSIOLOGY

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis

(2014) V. Pekovic-Vaughan et al.   GENES & DEVELOPMENT

Risk factors associated with the development of chronic kidney disease in cats evaluated at primary care veterinary hospitals

(2014) Joseph P. Greene et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

Chronic kidney disease and premature ageing

(2014) Jeroen P. Kooman et al.   Nature Reviews Nephrology

Antibiotic Suppression of Intestinal Microbiota Reduces Heme-Induced Lipoperoxidation Associated with Colon Carcinogenesis in Rats

(2014) O. C. B. Martin et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Delphinidin, One of the Major Anthocyanidins, Prevents Bone Loss through the Inhibition of Excessive Osteoclastogenesis in Osteoporosis Model Mice

(2014) Sawako Moriwaki et al.   PLoS One

Hydrogen sulfide augments survival signals in warm ischemia and reperfusion of the mouse liver

(2014) Shingo Shimada et al.   SURGERY TODAY

Renal Morphology in Cats With Diabetes Mellitus

(2014) E. Zini et al.   VETERINARY PATHOLOGY

High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III

(2013) Alex R Chang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Red Meat and Processed Meat Consumption and All-Cause Mortality: A Meta-Analysis

(2013) S. C. Larsson et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Chronic Kidney Disease: A Clinical Model of Premature Aging

(2013) Peter Stenvinkel et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Fibroblast Growth Factor 23 and Klotho: Physiology and Pathophysiology of an Endocrine Network of Mineral Metabolism

(2013) Ming Chang Hu et al.   Annual Review of Physiology

Kidney Biomimicry—A Rediscovered Scientific Field That Could Provide Hope to Patients with Kidney Disease

(2013) Peter Stenvinkel et al.   ARCHIVES OF MEDICAL RESEARCH

Elevated protein carbonylation and oxidative stress do not affect protein structure and function in the long-living naked-mole rat: A proteomic approach

(2013) Eric M. De Waal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment

(2013) Ricardo Villa-Bellosta et al.   CIRCULATION

High Anthocyanin Intake Is Associated With a Reduced Risk of Myocardial Infarction in Young and Middle-Aged Women

(2013) Aedín Cassidy et al.   CIRCULATION

Anatomic and Physiologic Changes of the Aging Kidney

(2013) Zeina Karam et al.   CLINICS IN GERIATRIC MEDICINE

Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction

(2013) Ines Sanchez-Roman et al.   EXPERIMENTAL GERONTOLOGY

Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization

(2013) Ran Xu et al.   EXPERIMENTAL NEUROLOGY

Resveratrol supplementation preserves long bone mass, microstructure, and strength in hindlimb-suspended old male rats

(2013) Stephanie M. Durbin et al.   JOURNAL OF BONE AND MINERAL METABOLISM

The sirtuin family’s role in aging and age-associated pathologies

(2013) Jessica A. Hall et al.   JOURNAL OF CLINICAL INVESTIGATION

Polyunsaturated fats, membrane lipids and animal longevity

(2013) A. J. Hulbert et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Ethanol extract of Alismatis Rhizoma reduces acute lung inflammation by suppressing NF-κB and activating Nrf2

(2013) Chang Woo Han et al.   JOURNAL OF ETHNOPHARMACOLOGY

Prolonged fasting activates Nrf2 in post-weaned elephant seals

(2013) J. P. Vazquez-Medina et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Feline CKD

(2013) Brice S Reynolds et al.   JOURNAL OF FELINE MEDICINE AND SURGERY

Serum Calcification Propensity Predicts All-Cause Mortality in Predialysis CKD

(2013) E. R. Smith et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Heart That Beats for 500 Years: Age-Related Changes in Cardiac Proteasome Activity, Oxidative Protein Damage and Expression of Heat Shock Proteins, Inflammatory Factors, and Mitochondrial Complexes in Arctica islandica, the Longest-Living Noncolonial Animal

(2013) D. Sosnowska et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

(2013) Xiao Tian et al.   NATURE

Mechanisms of vascular calcification in CKD—evidence for premature ageing?

(2013) Catherine M. Shanahan   Nature Reviews Nephrology

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caloric Restriction-Mediated Induction of Lipid Metabolism Gene Expression in Liver is Enhanced by Keap1-Knockdown

(2013) Supriya R. Kulkarni et al.   PHARMACEUTICAL RESEARCH

Membrane Phospholipid Fatty Acid Composition Regulates Cardiac SERCA Activity in a Hibernator, the Syrian Hamster (Mesocricetus auratus)

(2013) Sylvain Giroud et al.   PLoS One

Fetuin-A-Containing Calciprotein Particles Reduce Mineral Stress in the Macrophage

(2013) Edward R. Smith et al.   PLoS One

Metabolic Changes in Summer Active and Anuric Hibernating Free-Ranging Brown Bears (Ursus arctos)

(2013) Peter Stenvinkel et al.   PLoS One

Effect of a High-Protein Diet on Kidney Function in Healthy Adults: Results From the OmniHeart Trial

(2012) Stephen P. Juraschek et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

(2012) Guangdong Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

Sulforaphane inhibits restenosis by suppressing inflammation and the proliferation of vascular smooth muscle cells

(2012) Jin-Sook Kwon et al.   ATHEROSCLEROSIS

Dietary Nrf2 activators inhibit atherogenic processes

(2012) Bernhard H.J. Juurlink   ATHEROSCLEROSIS

Black bear parathyroid hormone has greater anabolic effects on trabecular bone in dystrophin-deficient mice than in wild type mice

(2012) Sarah K. Gray et al.   BONE

Brown Bears (Ursus arctos) Seem Resistant to Atherosclerosis ­Despite Highly Elevated Plasma Lipids during Hibernation and Active State

(2012) Karin Arinell et al.   CTS-Clinical and Translational Science

Unprocessed Red and Processed Meats and Risk of Coronary Artery Disease and Type 2 Diabetes – An Updated Review of the Evidence

(2012) Renata Micha et al.   Current Atherosclerosis Reports

Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy

(2012) Eva Andres-Mateos et al.   EMBO Molecular Medicine

Preservation of bone mass and structure in hibernating black bears (Ursus americanus) through elevated expression of anabolic genes

(2012) Vadim B. Fedorov et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

(2012) Miguel A. Lanaspa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coping with physiological oxidative stress: a review of antioxidant strategies in seals

(2012) José Pablo Vázquez-Medina et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Skeletal muscles of hibernating brown bears are unusually resistant to effects of denervation

(2012) David C. Lin et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats

(2012) Vernon W. Dolinsky et al.   JOURNAL OF PHYSIOLOGY-LONDON

Getting to the Heart of the Matter: Age-related Changes in Diastolic Heart Function in the Longest-lived Rodent, the Naked Mole Rat

(2012) K. M. Grimes et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli

(2012) Richard J. Glassock et al.   KIDNEY INTERNATIONAL

Hibernating bears (Ursidae): metabolic magicians of definite interest for the nephrologist

(2012) Peter Stenvinkel et al.   KIDNEY INTERNATIONAL

Uric Acid-Induced Endothelial Dysfunction Is Associated with Mitochondrial Alterations and Decreased Intracellular ATP Concentrations

(2012) Laura Gabriela Sánchez-Lozada et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Red Meat Consumption and Risk of Stroke

(2012) Joanna Kaluza et al.   STROKE

Resveratrol ameliorates metabolic disorders and muscle wasting in streptozotocin-induced diabetic rats

(2011) Kuan-Hsing Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Investigating the mechanism for maintaining eucalcemia despite immobility and anuria in the hibernating American black bear (Ursus americanus)

(2011) Rita L. Seger et al.   BONE

Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat

(2011) Iman Momken et al.   FASEB JOURNAL

Hypometabolism and basking: the strategies of Alpine ibex to endure harsh over-wintering conditions

(2011) Claudio Signer et al.   FUNCTIONAL ECOLOGY

Prolonged fasting increases glutathione biosynthesis in postweaned northern elephant seals

(2011) J. P. Vazquez-Medina et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Regulation of heart rate and rumen temperature in red deer: effects of season and food intake

(2011) C. Turbill et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Low Urine pH Is a Predictor of Chronic Kidney Disease

(2011) Naoko Nakanishi et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD

(2011) Edward R. Smith et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Purine-rich foods, protein intake, and the prevalence of hyperuricemia: The Shanghai Men’s Health Study

(2011) R. Villegas et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Diet-Independent Remodeling of Cellular Membranes Precedes Seasonally Changing Body Temperature in a Hibernator

(2011) Walter Arnold et al.   PLoS One

Hibernation is associated with increased survival and the evolution of slow life histories among mammals

(2011) C. Turbill et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Fatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growth

(2011) C. A. Riquelme et al.   SCIENCE

Hibernation in Black Bears: Independence of Metabolic Suppression from Body Temperature

(2011) O. Toien et al.   SCIENCE

Renal Protection From Prolonged Cold Ischemia and Warm Reperfusion in Hibernating Squirrels

(2011) Alkesh Jani et al.   TRANSPLANTATION

Hydrogen Sulfide and Hemeproteins: Knowledge and Mysteries

(2010) Ruth Pietri et al.   ANTIOXIDANTS & REDOX SIGNALING

Aging, frailty and age-related diseases

(2010) T. Fulop et al.   BIOGERONTOLOGY

Heme oxygenase expression and Nrf2 signaling during hibernation in ground squirrelsThis article is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Zhouli Ni et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Red and Processed Meat Consumption and Risk of Incident Coronary Heart Disease, Stroke, and Diabetes Mellitus

(2010) Renata Micha et al.   CIRCULATION

Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity

(2010) K. N. Lewis et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Hypercarnivory and the brain: protein requirements of cats reconsidered

(2010) Regina Eisert   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Chronic kidney disease: a public health priority and harbinger of premature cardiovascular disease

(2010) P. Stenvinkel   JOURNAL OF INTERNAL MEDICINE

Blueberries Decrease Cardiovascular Risk Factors in Obese Men and Women with Metabolic Syndrome

(2010) Arpita Basu et al.   JOURNAL OF NUTRITION

Bioactives in Blueberries Improve Insulin Sensitivity in Obese, Insulin-Resistant Men and Women

(2010) April J. Stull et al.   JOURNAL OF NUTRITION

Fetuin-Mineral Complex Reflects Extraosseous Calcification Stress in CKD

(2010) T. Hamano et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Changes in Serum Calcium, Phosphorus, and Magnesium Levels in Captive Ruminants Affected By Diet Manipulation

(2010) Michele Miller et al.   JOURNAL OF ZOO AND WILDLIFE MEDICINE

Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro

(2010) Andrew P. Sage et al.   KIDNEY INTERNATIONAL

A potential link between phosphate and aging—Lessons from Klotho-deficient mice

(2010) Makoto Kuro-o   MECHANISMS OF AGEING AND DEVELOPMENT

The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-Dependent Antioxidant Response in Human Epithelial Colon Cells

(2010) Georg Wondrak et al.   MOLECULES

Phosphonoformic Acid Prevents Vascular Smooth Muscle Cell Calcification by Inhibiting Calcium-Phosphate Deposition

(2009) Ricardo Villa-Bellosta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Nutrition integrates environmental responses of ungulates

(2009) Katherine L. Parker et al.   FUNCTIONAL ECOLOGY

Update on Slow Aging and Negligible Senescence – A Mini-Review

(2009) Caleb E. Finch   GERONTOLOGY

Six months of disuse during hibernation does not increase intracortical porosity or decrease cortical bone geometry, strength, or mineralization in black bear (Ursus americanus) femurs

(2009) Meghan E. McGee-Lawrence et al.   JOURNAL OF BIOMECHANICS

Ketohexokinase-Dependent Metabolism of Fructose Induces Proinflammatory Mediators in Proximal Tubular Cells

(2009) P. Cirillo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Caloric restriction, SIRT1 and longevity

(2009) Carles Cantó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Adaptive mechanisms regulate preferred utilization of ketones in the heart and brain of a hibernating mammal during arousal from torpor

(2008) Matthew T. Andrews et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Elevated serum levels of S-adenosylhomocysteine, but not homocysteine, are associated with cardiovascular disease in stage 5 chronic kidney disease patients

(2008) Alessandro Valli et al.   CLINICA CHIMICA ACTA

Soy Protein Intake, Cardiorenal Indices, and C-Reactive Protein in Type 2 Diabetes With Nephropathy: A longitudinal randomized clinical trial

(2008) L. Azadbakht et al.   DIABETES CARE

Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species

(2008) Rochelle Buffenstein   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Long-Term Effect of a Chicken-Based Diet Versus Enalapril on Albuminuria in Type 2 Diabetic Patients With Microalbuminuria

(2008) Vanessa D.F. de Mello et al.   JOURNAL OF RENAL NUTRITION

Cellular senescence and organismal aging

(2008) Jessie C. Jeyapalan et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

(2008) Melissa A. Merideth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Membranous glomerulonephritis in the Iberian lynx (Lynx pardinus)

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