Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats

Virgin Olive Oil and Hypertension

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Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation

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Pomegranate extract and exercise provide additive benefits on improvement of immune function by inhibiting inflammation and oxidative stress in high-fat-diet-induced obesity in rats

(2016) Fei Zhao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system

(2016) Chunhong Yan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

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A Randomized Trial of a Low-Fat Diet Intervention on Blood Pressure and Hypertension: Tertiary Analysis of the WHI Dietary Modification Trial

(2015) Matthew A. Allison et al.   AMERICAN JOURNAL OF HYPERTENSION

Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats

(2015) Apurva A. Javkhedkar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation

(2015) Adi Zheng et al.   BRITISH JOURNAL OF NUTRITION

Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs

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Mitochondrial oxidative stress and dysfunction induced by isoniazid: study on isolated rat liver and brain mitochondria

(2015) Morteza Ahadpour et al.   DRUG AND CHEMICAL TOXICOLOGY

Effects of Pomegranate Extract Supplementation on Cardiovascular Risk Factors and Physical Function in Hemodialysis Patients

(2015) Pei-Tzu Wu et al.   JOURNAL OF MEDICINAL FOOD

Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring

(2015) Adi Zheng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Inhibition of NF-κB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress

(2015) Xiao-Jing Yu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bioactive properties of commercialised pomegranate (Punica granatum) juice: antioxidant, antiproliferative and enzyme inhibiting activities

(2015) Francisco Les et al.   Food & Function

Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation

(2015) Ke Cao et al.   Scientific Reports

Mitochondrial Dysfunction in Obesity-Associated Nonalcoholic Fatty Liver Disease: The Protective Effects of Pomegranate with Its Active Component Punicalagin

(2014) Xuan Zou et al.   ANTIOXIDANTS & REDOX SIGNALING

AMPK activation prevents prenatal stress-induced cognitive impairment: Modulation of mitochondrial content and oxidative stress

(2014) Ke Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathogenesis of Target Organ Damage in Hypertension: Role of Mitochondrial Oxidative Stress

(2014) Speranza Rubattu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Effect of Punicalagin against Cerebral Ischemia Reperfusion-induced Oxidative Brain Injury in Rats

(2014) Lavanya Yaidikar et al.   Journal of Stroke & Cerebrovascular Diseases

Detection, evaluation, and treatment of severe and resistant hypertension

(2014) William B. White et al.   Journal of the American Society of Hypertension

Exercise Training Attenuates Hypertension and Cardiac Hypertrophy by Modulating Neurotransmitters and Cytokines in Hypothalamic Paraventricular Nucleus

(2014) Lin-Lin Jia et al.   PLoS One

Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats

(2014) Xin-Ai Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin–angiotensin system and proinflammatory cytokines in hypertension

(2014) Qing Su et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidative Stress, Prooxidants, and Antioxidants: The Interplay

(2014) Anu Rahal et al.   Biomed Research International

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

(2013) Chunfen Mo et al.   ANTIOXIDANTS & REDOX SIGNALING

AMP-activated protein kinase (AMPK) beyond metabolism

(2013) Toran Sanli et al.   CANCER BIOLOGY & THERAPY

Bioactive Natural Constituents from Food Sources—Potential Use in Hypertension Prevention and Treatment

(2013) Wu-Yang Huang et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants

(2013) Borut Poljsak et al.   Oxidative Medicine and Cellular Longevity

Superoxide Anions in Paraventricular Nucleus Modulate Adipose Afferent Reflex and Sympathetic Activity in Rats

(2013) Lei Ding et al.   PLoS One

Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines

(2013) Yu-Ming Kang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts

(2012) Baosheng Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Anti-proliferative activity and protection against oxidative DNA damage by punicalagin isolated from pomegranate husk

(2012) Farrukh Aqil et al.   FOOD RESEARCH INTERNATIONAL

Different role of oxidative stress in paraventricular nucleus and rostral ventrolateral medulla in cardiovascular regulation in awake spontaneously hypertensive rats

(2012) Masaaki Nishihara et al.   JOURNAL OF HYPERTENSION

SOD1 gene transfer into paraventricular nucleus attenuates hypertension and sympathetic activity in spontaneously hypertensive rats

(2012) Ning Yuan et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Peroxisome Proliferator-Activated Receptor-γ Regulates Inflammation and Renin-Angiotensin System Activity in the Hypothalamic Paraventricular Nucleus and Ameliorates Peripheral Manifestations of Heart Failure

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