From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

(2015) Christopher Hine et al.   CELL

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity

(2015) Siming Ma et al.   Cell Metabolism

UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity

(2015) Desiree Wanders et al.   FASEB JOURNAL

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

(2015) A. Gomez et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Protein and Calorie Restriction Contribute Additively to Protection from Renal Ischemia Reperfusion Injury Partly via Leptin Reduction in Male Mice

(2015) Lauren T Robertson et al.   JOURNAL OF NUTRITION

Dietary Methionine Restriction in Mice Elicits an Adaptive Cardiovascular Response to Hyperhomocysteinemia

(2015) Gene P. Ables et al.   Scientific Reports

The dietary proportion of essential amino acids and Sir2 influence lifespan in the honeybee

(2014) Pier P. Paoli et al.   AGE

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

(2014) Emma K. Lees et al.   AGING CELL

Methionine restriction slows down senescence in human diploid fibroblasts

(2014) Rafał Kozieł et al.   AGING CELL

Revisiting an age-old question regarding oxidative stress

(2014) Yael H. Edrey et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Methionine-Restricted Diet and Endurance Exercise Decrease Bone Mass and Extrinsic Strength but Increase Intrinsic Strength in Growing Male Rats

(2014) Tsang-Hai Huang et al.   JOURNAL OF NUTRITION

Gut microbiota–generated metabolites in animal health and disease

(2014) Won-Jae Lee et al.   Nature Chemical Biology

Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

(2014) Jay E. Johnson et al.   PLoS One

Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice

(2014) Raghu Sinha et al.   PROSTATE

Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification

(2014) Christoph Ruckenstuhl et al.   PLoS Genetics

The First International Mini-Symposium on Methionine Restriction and Lifespan

(2014) Gene P. Ables et al.   Frontiers in Genetics

Transcriptional impact of dietary methionine restriction on systemic inflammation: Relevance to biomarkers of metabolic disease during aging

(2013) Desiree Wanders et al.   BIOFACTORS

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat

(2013) Sreenivasa Maddineni et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice

(2013) Holly M. Brown-Borg et al.   EXPERIMENTAL GERONTOLOGY

Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction

(2013) Ines Sanchez-Roman et al.   EXPERIMENTAL GERONTOLOGY

Specific Lipidome Signatures in Central Nervous System from Methionine-Restricted Mice

(2013) Mariona Jové et al.   JOURNAL OF PROTEOME RESEARCH

Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity

(2013) Ziyun Wu et al.   PLoS One

The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613

(2012) John M. Hourihan et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

(2012) Inés Sanchez-Roman et al.   BIOGERONTOLOGY

Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents

(2012) Carmen E. Perrone et al.   EXPERIMENTAL GERONTOLOGY

Activation of Nrf2 Is Required for Up-Regulation of the π Class of Glutathione S-Transferase in Rat Primary Hepatocytes with l-Methionine Starvation

(2012) Ai-Hsuan Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway

(2012) R. Scott McIsaac et al.   MOLECULAR BIOLOGY OF THE CELL

Combinatorial control of diverse metabolic and physiological functions by transcriptional regulators of the yeast sulfur assimilation pathway

(2012) Allegra A. Petti et al.   MOLECULAR BIOLOGY OF THE CELL

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density

(2012) Gene P. Ables et al.   PLoS One

Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

(2012) Cathy Slack et al.   PLoS One

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor  

(2012) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

Dietary Methionine Restriction Increases Fat Oxidation in Obese Adults with Metabolic Syndrome

(2011) Eric P. Plaisance et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metabolic rate and membrane fatty acid composition in birds: a comparison between long-living parrots and short-living fowl

(2011) Magdalene K. Montgomery et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast

(2011) Mark J. Hickman et al.   MOLECULAR BIOLOGY OF THE CELL

Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function

(2011) A. A. Petti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrially encoded methionine is inversely related to longevity in mammals

(2010) Juan Carlos Aledo et al.   AGING CELL

Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states

(2010) Barbara E. Hasek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hydrogen Sulfide and Hemeproteins: Knowledge and Mysteries

(2010) Ruth Pietri et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity

(2010) K. N. Lewis et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Redox Biochemistry of Hydrogen Sulfide

(2010) Omer Kabil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase

(2010) Amany K. Elshorbagy et al.   JOURNAL OF LIPID RESEARCH

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

(2010) R. K. Minor et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

NRF2, cancer and calorie restriction

(2010) A Martín-Montalvo et al.   ONCOGENE

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet☆

(2010) Yu-Kun Jennifer Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

(2010) Valter D. Longo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production

(2009) Luigi Fontana et al.   AGE

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

(2009) Chen-Yu Liao et al.   AGING CELL

Tissue-specific deiodinase regulation during food restriction and low replacement dose of leptin in rats

(2009) R. L. Araujo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect

(2009) Joshua R. Veatch et al.   CELL

Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling

(2009) John W. Calvert et al.   CIRCULATION RESEARCH

The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis

(2009) Adam B. Salmon et al.   FASEB JOURNAL

Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span

(2009) Adam B. Salmon et al.   FASEB JOURNAL

Alterations in Oxygen Consumption, Respiratory Quotient, and Heat Production in Long-Lived GHRKO and Ames Dwarf Mice, and Short-Lived bGH Transgenic Mice

(2009) Reyhan Westbrook et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice

(2009) Y. Ikeno et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction

(2008) Mónica López-Torres et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver

(2008) Pilar Caro et al.   BIOGERONTOLOGY

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism

Sex-Specific Fitness Effects of Nutrient Intake on Reproduction and Lifespan

(2008) Alexei A. Maklakov et al.   CURRENT BIOLOGY

Influence of genotype and nutrition on survival and metabolism of starving yeast

(2008) V. M. Boer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

(2008) K. J. Pearson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive antioxidant methionine accumulation in respiratory chain complexes explains the use of a deviant genetic code in mitochondria

(2008) A. Bender et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrially encoded cysteine predicts animal lifespan

(2007) Bernd Moosmann et al.   AGING CELL

Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast

(2007) Matthew J. Brauer et al.   MOLECULAR BIOLOGY OF THE CELL