Multidrug efflux pumps: structure, function and regulation

Water-mediated interactions enable smooth substrate transport in a bacterial efflux pump

(2018) Attilio Vittorio Vargiu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

New insights into the structural and functional involvement of the gate loop in AcrB export activity

(2018) Abdessamad Ababou   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

(2018) Martijn Zwama et al.   Nature Communications

Split tasks of asymmetric nucleotide-binding sites in the heterodimeric ABC exporter EfrCD

(2017) Lea M. Hürlimann et al.   FEBS Journal

Distribution of different efflux pump genes in clinical isolates of multidrug-resistant Acinetobacter baumannii and their correlation with antimicrobial resistance

(2017) Ming-Feng Lin et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Molecular characterization of antimicrobial susceptibility of Salmonella isolates: First identification of a plasmid carrying qnrD or oqxAB in Taiwan

(2017) Cheng-Yen Kao et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Transporters as information processors in bacterial signalling pathways

(2017) Hannah Piepenbreier et al.   MOLECULAR MICROBIOLOGY

Metabolic constraints on the evolution of antibiotic resistance

(2017) Mattia Zampieri et al.   Molecular Systems Biology

Protein–phospholipid interplay revealed with crystals of a calcium pump

(2017) Yoshiyuki Norimatsu et al.   NATURE

Structural basis of MsbA-mediated lipopolysaccharide transport

(2017) Wei Mi et al.   NATURE

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

(2017) Brandy Verhalen et al.   NATURE

Crystal structures of theBurkholderia multivoranshopanoid transporter HpnN

(2017) Nitin Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stable membrane orientations of small dual-topology membrane proteins

(2017) Nir Fluman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily

(2017) Allister Crow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of transmembrane signaling by sensor histidine kinases

(2017) Ivan Gushchin et al.   SCIENCE

Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity

(2017) Tobias Bergmiller et al.   SCIENCE

The Vibrio cholerae VexGH RND Efflux System Maintains Cellular Homeostasis by Effluxing Vibriobactin

(2017) Dillon E. Kunkle et al.   mBio

Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

(2017) Xuan Wang-Kan et al.   mBio

Severe infections emerge from commensal bacteria by adaptive evolution

(2017) Bernadette C Young et al.   eLife

Roles of Regulatory RNAs for Antibiotic Resistance in Bacteria and Their Potential Value as Novel Drug Targets

(2017) Petra Dersch et al.   Frontiers in Microbiology

Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis

(2017) Diana Machado et al.   Frontiers in Microbiology

Structure of the MacAB–TolC ABC-type tripartite multidrug efflux pump

(2017) Anthony W. P. Fitzpatrick et al.   Nature Microbiology

Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System

(2016) Keith Poole et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The GAS PefCD exporter is a MDR system that confers resistance to heme and structurally diverse compounds

(2016) Ankita J. Sachla et al.   BMC MICROBIOLOGY

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

Multidrug efflux pumps of Gram-positive bacteria

(2016) Bryan D. Schindler et al.   DRUG RESISTANCE UPDATES

Single amino acid substitution Gly186Val in AdeS restores tigecycline susceptibility ofAcinetobacter baumannii

(2016) Jun-Ren Sun et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Small RNA Regulation of TolC, the Outer Membrane Component of Bacterial Multidrug Transporters

(2016) Ashley Parker et al.   JOURNAL OF BACTERIOLOGY

Disulfide Cross-linking of a Multidrug and Toxic Compound Extrusion Transporter Impacts Multidrug Efflux

(2016) Martha Radchenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of polyspecificity of the Small Multidrug Resistance Efflux Pump AbeS from Acinetobacter baumannii

(2016) Iryna Lytvynenko et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Mechanisms of Two-Component Signal Transduction

(2016) Christopher P. Zschiedrich et al.   JOURNAL OF MOLECULAR BIOLOGY

AdeR protein regulates adeABC expression by binding to a direct-repeat motif in the intercistronic spacer

(2016) Tein-Yao Chang et al.   MICROBIOLOGICAL RESEARCH

Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells

(2016) Yingying Pu et al.   MOLECULAR CELL

Protonation of a glutamate residue modulates the dynamics of the drug transporter EmrE

(2016) Anindita Gayen et al.   Nature Chemical Biology

Elevating the alternating-access model

(2016) Renae M Ryan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the MOP flippase MurJ in an inward-facing conformation

(2016) Alvin C Y Kuk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TransportDB 2.0: a database for exploring membrane transporters in sequenced genomes from all domains of life

(2016) Liam D. H. Elbourne et al.   NUCLEIC ACIDS RESEARCH

ThePseudomonas aeruginosaefflux pump MexGHI-OpmD transports a natural phenazine that controls gene expression and biofilm development

(2016) Hassan Sakhtah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

(2016) Hanno Sjuts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protonation-dependent conformational dynamics of the multidrug transporter EmrE

(2016) Reza Dastvan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria

(2016) D. Dar et al.   SCIENCE

Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

(2016) Christine Oswald et al.   Nature Communications

Elevating the alternating-access model

(2016) Renae M Ryan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the MOP flippase MurJ in an inward-facing conformation

(2016) Alvin C Y Kuk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multidrug Efflux Pumps at the Crossroad between Antibiotic Resistance and Bacterial Virulence

(2016) Manuel Alcalde-Rico et al.   Frontiers in Microbiology

MATE transport of the E. coli-derived genotoxin colibactin

(2016) Jarrod J. Mousa et al.   Nature Microbiology

The Asp20-to-Asn Substitution in the Response Regulator AdeR Leads to Enhanced Efflux Activity of AdeB in Acinetobacter baumannii

(2015) Jennifer Nowak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Substrate-bound structure of the E. coli multidrug resistance transporter MdfA

(2015) Jie Heng et al.   CELL RESEARCH

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Treatment of MDR-Gram negative infections in the 21st century: a never ending threat for clinicians

(2015) Pierluigi Viale et al.   CURRENT OPINION IN PHARMACOLOGY

Specificity Determinants in Small Multidrug Transporters

(2015) Shlomo Brill et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and mechanism of an active lipid-linked oligosaccharide flippase

(2015) Camilo Perez et al.   NATURE

AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity

(2015) Jessica M. A. Blair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A chemiosmotic mechanism of symport

(2015) H. Ronald Kaback   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homologs of the Acinetobacter baumannii AceI Transporter Represent a New Family of Bacterial Multidrug Efflux Systems

(2015) Karl A. Hassan et al.   mBio

A New Way of Sensing: Need-Based Activation of Antibiotic Resistance by a Flux-Sensing Mechanism

(2015) Georg Fritz et al.   mBio

Structural basis for the blockade of MATE multidrug efflux pumps

(2015) Martha Radchenko et al.   Nature Communications

Dual-topology insertion of a dual-topology membrane protein

(2015) Nicholas B. Woodall et al.   Nature Communications

Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

(2015) Shyamasree De Majumdar et al.   PLoS Pathogens

Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa

(2015) Jürg Dreier et al.   Frontiers in Microbiology

Structural basis of RND-type multidrug exporters

(2015) Akihito Yamaguchi et al.   Frontiers in Microbiology

Small Proteins Can No Longer Be Ignored

(2014) Gisela Storz et al.   Annual Review of Biochemistry

Switch-Loop Flexibility Affects Transport of Large Drugs by the Promiscuous AcrB Multidrug Efflux Transporter

(2014) Hi-jea Cha et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Importance of Multidrug Efflux Pumps in the Antimicrobial Resistance Property of Clinical Multidrug-Resistant Isolates of Neisseria gonorrhoeae

(2014) Daniel Golparian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Overproduction of the MtrCDE Efflux Pump in Neisseria gonorrhoeae Produces Unexpected Changes in Cellular Transcription Patterns

(2014) Elizabeth A. Ohneck et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Active Efflux Influences the Potency of Quorum Sensing Inhibitors inPseudomonas aeruginosa

(2014) Joseph D. Moore et al.   CHEMBIOCHEM

Multidrug Transport Protein NorM fromVibrio choleraeSimultaneously Couples to Sodium- and Proton-Motive Force

(2014) Yoonhee Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the AcrAB–TolC multidrug efflux pump

(2014) Dijun Du et al.   NATURE

Crystal structure of the plant dual-affinity nitrate transporter NRT1.1

(2014) Ji Sun et al.   NATURE

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump

(2014) Jani Reddy Bolla et al.   PLoS One

AcrB, AcrD, and MdtABC Multidrug Efflux Systems Are Involved in Enterobactin Export in Escherichia coli

(2014) Tsukasa Horiyama et al.   PLoS One

Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline

(2014) Koen Andries et al.   PLoS One

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

(2014) A. Kodan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

(2014) H. G. Choudhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the E. coli Peptide Transporter YbgH

(2014) Yan Zhao et al.   STRUCTURE

Export of a single drug molecule in two transport cycles by a multidrug efflux pump

(2014) Nir Fluman et al.   Nature Communications

Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE

(2014) Goragot Wisedchaisri et al.   Nature Communications

Regulatory RNAs Involved in Bacterial Antibiotic Resistance

(2014) David Lalaouna et al.   PLoS Pathogens

The hierarchy quorum sensing network in Pseudomonas aeruginosa

(2014) Jasmine Lee et al.   Protein & Cell

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

(2014) Thomas Eicher et al.   eLife

Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

(2014) Smriti Mishra et al.   eLife

The BpeEF-OprC Efflux Pump Is Responsible for Widespread Trimethoprim Resistance in Clinical and Environmental Burkholderia pseudomallei Isolates

(2013) Nicole L. Podnecky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Na+–Substrate Coupling in the Multidrug Antiporter NorM Probed with a Spin-Labeled Substrate

(2013) P. Ryan Steed et al.   BIOCHEMISTRY

Some Ligands Enhance the Efflux of Other Ligands by the Escherichia coli Multidrug Pump AcrB

(2013) Alfred D. Kinana et al.   BIOCHEMISTRY

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

Control of RNA Stability by NrrF, an Iron-Regulated Small RNA in Neisseria gonorrhoeae

(2013) L. A. Jackson et al.   JOURNAL OF BACTERIOLOGY

Structural basis for the inhibition of bacterial multidrug exporters

(2013) Ryosuke Nakashima et al.   NATURE

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

(2013) Yoshiki Tanaka et al.   NATURE

Protonation drives the conformational switch in the multidrug transporter LmrP

(2013) Matthieu Masureel et al.   Nature Chemical Biology

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

(2013) Esben M Quistgaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into H+-coupled multidrug extrusion by a MATE transporter

(2013) Min Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of a Na+-coupled, substrate-bound MATE multidrug transporter

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins

(2013) K. A. Hassan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A

(2013) Daohua Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ABC-Type Efflux Pump MacAB Protects Salmonella enterica serovar Typhimurium from Oxidative Stress

(2013) L. M. Bogomolnaya et al.   mBio

Role of the Mmr Efflux Pump in Drug Resistance in Mycobacterium tuberculosis

(2012) L. Rodrigues et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Different Functions of MdtB and MdtC Subunits in the Heterotrimeric Efflux Transporter MdtB2C Complex of Escherichia coli

(2012) Hong-Suk Kim et al.   BIOCHEMISTRY

RND type efflux pump system MexAB-OprM of pseudomonas aeruginosa selects bacterial languages, 3-oxo-acyl-homoserine lactones, for cell-to-cell communication

(2012) Shu Minagawa et al.   BMC MICROBIOLOGY

Dissection of Mechanistic Principles of a Secondary Multidrug Efflux Protein

(2012) Nir Fluman et al.   MOLECULAR CELL

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Structure of AMP-PNP-bound vitamin B12 transporter BtuCD–F

(2012) Vladimir M. Korkhov et al.   NATURE

X-ray structure of the Yersinia pestis heme transporter HmuUV

(2012) Jae-Sung Woo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance

(2012) E. C. Hobbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

(2012) T. Eicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Rewiring two-component signal transduction with small RNAs

(2011) Yvonne Göpel et al.   CURRENT OPINION IN MICROBIOLOGY

The Alternating-Access Mechanism of MFS Transporters Arises from Inverted-Topology Repeats

(2011) Sebastian Radestock et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and function of a membrane component SecDF that enhances protein export

(2011) Tomoya Tsukazaki et al.   NATURE

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

Antiparallel EmrE exports drugs by exchanging between asymmetric structures

(2011) Emma A. Morrison et al.   NATURE

MexEF-OprN Efflux Pump Exports the Pseudomonas Quinolone Signal (PQS) Precursor HHQ (4-hydroxy-2-heptylquinoline)

(2011) Martin G. Lamarche et al.   PLoS One

Expression of Multidrug Efflux Pump GenesacrAB-tolC,mdfA, andnorEinEscherichia coliClinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance

(2010) Michelle C. Swick et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phenotypic Landscape of a Bacterial Cell

(2010) Robert J. Nichols et al.   CELL

Antimicrobial Resistance in the Intensive Care Unit: Mechanisms, Epidemiology, and Management of Specific Resistant Pathogens

(2010) Henry S. Fraimow et al.   CRITICAL CARE CLINICS

A flexible cation binding site in the multidrug major facilitator superfamily transporter LmrP is associated with variable proton coupling

(2010) Theresia A. Schaedler et al.   FASEB JOURNAL

Impact of the RNA chaperone Hfq on multidrug resistance in Escherichia coli

(2010) J. Yamada et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli

(2010) K. Nishino et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

RamA, a Member of the AraC/XylS Family, Influences Both Virulence and Efflux in Salmonella enterica Serovar Typhimurium

(2010) A. M. Bailey et al.   JOURNAL OF BACTERIOLOGY

Mutation ofnfxBCauses Global Changes in the Physiology and Metabolism ofPseudomonas aeruginosa

(2010) Hannah G. Stickland et al.   JOURNAL OF PROTEOME RESEARCH

Structure of a cation-bound multidrug and toxic compound extrusion transporter

(2010) Xiao He et al.   NATURE

A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor

(2010) Kalinka Koteva et al.   Nature Chemical Biology

Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii

(2009) V. B. Srinivasan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crucial Role of Asp408 in the Proton Translocation Pathway of Multidrug Transporter AcrB: Evidence from Site-Directed Mutagenesis and Carbodiimide Labeling

(2009) Markus A. Seeger et al.   BIOCHEMISTRY

Drug transport mechanism of the AcrB efflux pump

(2009) Klaas M. Pos   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction

(2009) Patricia Casino et al.   CELL

Alternating Access in Maltose Transporter Mediated by Rigid-Body Rotations

(2009) Dheeraj Khare et al.   MOLECULAR CELL

A coordinated network of transporters with overlapping specificities provides a robust survival strategy

(2009) N. Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MacAB Is Involved in the Secretion of Escherichia coli Heat-Stable Enterotoxin II

(2008) H. Yamanaka et al.   JOURNAL OF BACTERIOLOGY

MacB ABC Transporter Is a Dimer Whose ATPase Activity and Macrolide-binding Capacity Are Regulated by the Membrane Fusion Protein MacA

(2008) Hong Ting Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB

(2008) Stephanie K. Aoki et al.   MOLECULAR MICROBIOLOGY

The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR

(2008) M. S. Wilke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism

(2008) H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small multidrug resistance proteins: A multidrug transporter family that continues to grow

(2007) Denice C. Bay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES