Mechanistic diversity in ATP-binding cassette (ABC) transporters

A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter

(2016) Michael L. Oldham et al.   NATURE

Prediction of drug–ABC-transporter interaction — Recent advances and future challenges

(2015) Floriane Montanari et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipid flopping in the liver

(2015) K. J. Linton   BIOCHEMICAL SOCIETY TRANSACTIONS

Watching conformational dynamics of ABC transporters with single-molecule tools

(2015) F. Husada et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Investigating the dynamic nature of the ABC transporters: ABCB1 and MsbA as examples for the potential synergies of MD theory and EPR applications

(2015) T. Stockner et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The substrate-binding protein in bacterial ABC transporters: dissecting roles in the evolution of substrate specificity

(2015) A. Maqbool et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Conformational Changes of the Antibacterial Peptide ATP Binding Cassette Transporter McjD Revealed by Molecular Dynamics Simulations

(2015) Ruo-Xu Gu et al.   BIOCHEMISTRY

Multiple Drug Transport Pathways through Human P-Glycoprotein

(2015) James W. McCormick et al.   BIOCHEMISTRY

The transporter associated with antigen processing: a key player in adaptive immunity

(2015) Sabine Eggensperger et al.   BIOLOGICAL CHEMISTRY

The Allosteric Regulatory Mechanism of theEscherichia coliMetNI Methionine ATP Binding Cassette (ABC) Transporter

(2015) Janet G. Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structures of a polypeptide processing and secretion transporter

(2015) David Yin-wei Lin et al.   NATURE

Structure and mechanism of an active lipid-linked oligosaccharide flippase

(2015) Camilo Perez et al.   NATURE

Structure of a Bacterial ABC Transporter Involved in the Import of an Acidic Polysaccharide Alginate

(2015) Yukie Maruyama et al.   STRUCTURE

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

(2014) Jessica H. van Wonderen et al.   FEBS Journal

Structural diversity of ABC transporters

(2014) Josy ter Beek et al.   JOURNAL OF GENERAL PHYSIOLOGY

Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter

(2014) JungMin Kim et al.   NATURE

Structure of AMP-PNP–bound BtuCD and mechanism of ATP-powered vitamin B12 transport by BtuCD–F

(2014) Vladimir M Korkhov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter

(2014) M. Hohl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

(2014) A. Kodan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

(2014) H. G. Choudhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A reciprocating twin-channel model for ABC transporters

(2014) Peter M. Jones et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Crystal Structures of Nucleotide-Free and Glutathione-Bound Mitochondrial ABC Transporter Atm1

(2014) V. Srinivasan et al.   SCIENCE

Structural Basis for Heavy Metal Detoxification by an Atm1-Type ABC Exporter

(2014) J. Y. Lee et al.   SCIENCE

The Resolution Revolution

(2014) W. Kuhlbrandt   SCIENCE

Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter

(2014) Nina Grossmann et al.   Nature Communications

Molecular Mechanisms for Biliary Phospholipid and Drug Efflux Mediated by ABCB4 and Bile Salts

(2014) Shin-ya Morita et al.   Biomed Research International

Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

(2014) Smriti Mishra et al.   eLife

Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters

(2013) Wei Hao Zheng et al.   BMC MICROBIOLOGY

Structure, biosynthesis, and function of bacterial capsular polysaccharides synthesized by ABC transporter-dependent pathways

(2013) Lisa M. Willis et al.   CARBOHYDRATE RESEARCH

Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis

(2013) Ke Xu et al.   NATURE

Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography

(2013) Shanshuang Chen et al.   NATURE

Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)

(2013) Eduardo E. Chufan et al.   PLoS One

Mechanistic picture for conformational transition of a membrane transporter at atomic resolution

(2013) M. Moradi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

(2013) C. A. Shintre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

(2013) A. B. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

(2013) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Towards understanding promiscuity in multidrug efflux pumps

(2013) Kelvin Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure and mechanism of energy-coupling factor transporters

(2013) Peng Zhang   TRENDS IN MICROBIOLOGY

Asymmetry in the Homodimeric ABC Transporter MsbA Recognized by a DARPin

(2012) Anshumali Mittal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Structure of AMP-PNP-bound vitamin B12 transporter BtuCD–F

(2012) Vladimir M. Korkhov et al.   NATURE

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

(2012) Michael Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Perspectives on the structure–function of ABC transporters: The Switch and Constant Contact Models

(2012) Anthony M. George et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Evolution of ABC transporters by gene duplication and their role in human disease

(2011) Karobi Moitra et al.   BIOLOGICAL CHEMISTRY

Recent insights into iron import by bacteria

(2011) Volkmar Braun et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Advances in the Molecular Detection of ABC Transporters Involved in Multidrug Resistance in Cancer

(2011) Jean-Pierre Gillet et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The TAP translocation machinery in adaptive immunity and viral escape mechanisms

(2011) Rupert Abele et al.   Essays in Biochemistry

ABC transporters involved in drug resistance in human parasites

(2011) Philippe Leprohon et al.   Essays in Biochemistry

The controversial role of ABC transporters in clinical oncology

(2011) Akina Tamaki et al.   Essays in Biochemistry

ABC solute importers in bacteria

(2011) Jinming Cui et al.   Essays in Biochemistry

The P-glycoprotein multidrug transporter

(2011) Frances J. Sharom   Essays in Biochemistry

Transmembrane Gate Movements in the Type II ATP-binding Cassette (ABC) Importer BtuCD-F during Nucleotide Cycle

(2011) Benesh Joseph et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Canalicular ABC transporters and liver disease

(2011) Michael Nicolaou et al.   JOURNAL OF PATHOLOGY

Conformation of peptides bound to the transporter associated with antigen processing (TAP)

(2011) M. Herget et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human P-glycoprotein is active when the two halves are clamped together in the closed conformation

(2010) Tip W. Loo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A structural classification of substrate-binding proteins

(2010) Ronnie P.-A. Berntsson et al.   FEBS LETTERS

Asymmetric ATP Hydrolysis Cycle of the Heterodimeric Multidrug ABC Transport Complex TmrAB fromThermus thermophilus

(2010) Ariane Zutz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABC Transporters Involved in Export of Cell Surface Glycoconjugates

(2010) L. Cuthbertson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

(2009) Bruno Stieger   DRUG METABOLISM REVIEWS

The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter

(2009) Erik Procko et al.   FASEB JOURNAL

Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues

(2009) Ian D. Kerr et al.   FEBS Journal

Membrane Porters of ATP-Binding Cassette Transport Systems Are Polyphyletic

(2009) Bin Wang et al.   JOURNAL OF MEMBRANE BIOLOGY

ABC transporters: the power to change

(2009) Douglas C. Rees et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CFTR Function and Prospects for Therapy

(2008) John R. Riordan   Annual Review of Biochemistry

Mutational analysis of ABC proteins

(2008) Tip W. Loo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Molecular basis of multidrug transport by ABC transporters

(2008) Markus A. Seeger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structural insights into ABC transporter mechanism

(2008) Michael L Oldham et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Distinct gate conformations of the ABC transporter BtuCD revealed by electron spin resonance spectroscopy and chemical cross-linking

(2008) Birke A. Goetz et al.   FEBS LETTERS

Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems

(2008) A. L. Davidson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator

(2008) D. Muallem et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator

(2008) J. Aittoniemi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Structure and mechanism of ATP-binding cassette transporters

(2008) K. P Locher   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli

(2008) N. Ruiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Trans-Inhibition in a Molybdate/Tungstate ABC Transporter

(2008) S. Gerber et al.   SCIENCE

The High-Affinity E. coli Methionine ABC Transporter: Structure and Allosteric Regulation

(2008) N. S. Kadaba et al.   SCIENCE