Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrB

(2016) Sabine Schuster et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial resistance – a ‘rising tide’ of national (and international) risk

(2016) J. Cole   JOURNAL OF HOSPITAL INFECTION

Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

(2016) Christine Oswald et al.   Nature Communications

Tripartite assembly of RND multidrug efflux pumps

(2016) Laetitia Daury et al.   Nature Communications

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Suggests an Alternative Assembly Mode

(2015) Jin-Sik Kim et al.   MOLECULES AND CELLS

Switch-Loop Flexibility Affects Transport of Large Drugs by the Promiscuous AcrB Multidrug Efflux Transporter

(2014) Hi-jea Cha et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure of the AcrAB–TolC multidrug efflux pump

(2014) Dijun Du et al.   NATURE

AcrB, AcrD, and MdtABC Multidrug Efflux Systems Are Involved in Enterobactin Export in Escherichia coli

(2014) Tsukasa Horiyama et al.   PLoS One

Export of a single drug molecule in two transport cycles by a multidrug efflux pump

(2014) Nir Fluman et al.   Nature Communications

Structural basis for the inhibition of bacterial multidrug exporters

(2013) Ryosuke Nakashima et al.   NATURE

The crystal structure of multidrug-resistance regulator RamR with multiple drugs

(2013) Suguru Yamasaki et al.   Nature Communications

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

(2012) T. Eicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vestibules Are Part of the Substrate Path in the Multidrug Efflux Transporter AcrB of Escherichia coli

(2011) F. Husain et al.   JOURNAL OF BACTERIOLOGY

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

Promiscuous partnering and independent activity of MexB, the multidrug transporter protein fromPseudomonas aeruginosa

(2010) Alexander Welch et al.   BIOCHEMICAL JOURNAL

Substrate path in the AcrB multidrug efflux pump of Escherichia coli

(2010) Fasahath Husain et al.   MOLECULAR MICROBIOLOGY

EmrE, a model for studying evolution and mechanism of ion-coupled transporters

(2009) Shimon Schuldiner   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Crystal Structure of the Multidrug Exporter MexB from Pseudomonas aeruginosa

(2009) Gaby Sennhauser et al.   JOURNAL OF MOLECULAR BIOLOGY

A coordinated network of transporters with overlapping specificities provides a robust survival strategy

(2009) N. Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The AraC-family regulator GadX enhances multidrug resistance in Escherichia coli by activating expression of mdtEF multidrug efflux genes

(2008) Kunihiko Nishino et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY