Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS

(2011) Lorenz Brandstätter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Vestibules Are Part of the Substrate Path in the Multidrug Efflux Transporter AcrB of Escherichia coli

(2011) F. Husain et al.   JOURNAL OF BACTERIOLOGY

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Kinetic Parameters of Efflux of Penicillins by the Multidrug Efflux Transporter AcrAB-TolC of Escherichia coli

(2010) S. P. Lim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Substrate path in the AcrB multidrug efflux pump of Escherichia coli

(2010) Fasahath Husain et al.   MOLECULAR MICROBIOLOGY

Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport

(2010) Feng Long et al.   NATURE

Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations

(2010) Xin-Qiu Yao et al.   Nature Communications

Crucial Role of Asp408 in the Proton Translocation Pathway of Multidrug Transporter AcrB: Evidence from Site-Directed Mutagenesis and Carbodiimide Labeling

(2009) Markus A. Seeger et al.   BIOCHEMISTRY

Drug transport mechanism of the AcrB efflux pump

(2009) Klaas M. Pos   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The assembled structure of a complete tripartite bacterial multidrug efflux pump

(2009) M. F. Symmons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli

(2009) K. Nagano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Site-Directed Mutagenesis Reveals Amino Acid Residues in the Escherichia coli RND Efflux Pump AcrB That Confer Macrolide Resistance

(2008) C. Wehmeier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanisms of RND multidrug efflux pumps

(2008) Hiroshi Nikaido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The AcrB Efflux Pump: Conformational Cycling and Peristalsis Lead to Multidrug Resistance

(2008) Markus Seeger et al.   CURRENT DRUG TARGETS

Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB

(2008) J. A. Bohnert et al.   JOURNAL OF BACTERIOLOGY

Covalently Linked Trimer of the AcrB Multidrug Efflux Pump Provides Support for the Functional Rotating Mechanism

(2008) Y. Takatsuka et al.   JOURNAL OF BACTERIOLOGY

The structure of the efflux pump AcrB in complex with bile acid

(2008) David Drew et al.   MOLECULAR MEMBRANE BIOLOGY

Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB

(2008) Markus A Seeger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY