Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors

(2015) Son T. Nguyen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Structure, mechanism and cooperation of bacterial multidrug transporters

(2015) Dijun Du et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors

(2014) Attilio V. Vargiu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure of the AcrAB–TolC multidrug efflux pump

(2014) Dijun Du et al.   NATURE

Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

(2014) Weiwei Wang et al.   eLife

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

(2013) Timothy J. Opperman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RND Efflux Pumps: Structural Information Translated into Function and Inhibition Mechanisms

(2013) Paolo Ruggerone et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structural basis for the inhibition of bacterial multidrug exporters

(2013) Ryosuke Nakashima et al.   NATURE

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

(2012) A. V. Vargiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

(2012) T. Eicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Versatile and Efficient High-Throughput Cloning Tool for Structural Biology

(2011) Eric R. Geertsma et al.   BIOCHEMISTRY

Effect of the F610A Mutation on Substrate Extrusion in the AcrB Transporter: Explanation and Rationale by Molecular Dynamics Simulations

(2011) Attilio V. Vargiu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

Challenges and opportunities for new protein crystallization strategies in structure-based drug design

(2010) Jessica Lynn Grey et al.   Expert Opinion on Drug Discovery

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

(2010) Y. Takatsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug transport mechanism of the AcrB efflux pump

(2009) Klaas M. Pos   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli

(2009) K. Nagano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB

(2008) Markus A Seeger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY