Roles of Regulatory RNAs for Antibiotic Resistance in Bacteria and Their Potential Value as Novel Drug Targets

Noisy Response to Antibiotic Stress Predicts Subsequent Single-Cell Survival in an Acidic Environment

(2017) Karin Mitosch et al.   Cell Systems

sRNA-Mediated Control of Transcription Termination in E. coli

(2016) Nadezda Sedlyarova et al.   CELL

Hfq: the flexible RNA matchmaker

(2016) Taylor B Updegrove et al.   CURRENT OPINION IN MICROBIOLOGY

Identifying targets for antibiotic development using omics technologies

(2016) Marina R. Pulido et al.   DRUG DISCOVERY TODAY

Discovery of the first small-molecule CsrA–RNA interaction inhibitors using biophysical screening technologies

(2016) Christine K Maurer et al.   Future Medicinal Chemistry

Small RNA Regulation of TolC, the Outer Membrane Component of Bacterial Multidrug Transporters

(2016) Ashley Parker et al.   JOURNAL OF BACTERIOLOGY

A feed-forward loop between SroC and MgrR small RNAs modulates the expression of eptB and the susceptibility to polymyxin B in Salmonella Typhimurium

(2016) Lillian G. Acuña et al.   MICROBIOLOGY-SGM

The green tea polyphenol EGCG inhibitsE. colibiofilm formation by impairing amyloid curli fibre assembly and downregulating the biofilm regulator CsgD via the σE-dependent sRNA RybB

(2016) Diego O. Serra et al.   MOLECULAR MICROBIOLOGY

Competing endogenous RNAs: a target-centric view of small RNA regulation in bacteria

(2016) Lionello Bossi et al.   NATURE REVIEWS MICROBIOLOGY

The target spectrum of SdsR small RNA inSalmonella

(2016) Kathrin S. Fröhlich et al.   NUCLEIC ACIDS RESEARCH

Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center

(2016) James Marks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Grad-seq guides the discovery of ProQ as a major small RNA-binding protein

(2016) Alexandre Smirnov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-based mechanisms of virulence control in Enterobacteriaceae

(2016) Ann Kathrin Heroven et al.   RNA Biology

Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria

(2016) D. Dar et al.   SCIENCE

Discovery and Function of a General Core Hormetic Stress Response in E. coli Induced by Sublethal Concentrations of Antibiotics

(2016) Aurélie Mathieu et al.   Cell Reports

Two Small RNAs Conserved in Enterobacteriaceae Provide Intrinsic Resistance to Antibiotics Targeting the Cell Wall Biosynthesis Enzyme Glucosamine-6-Phosphate Synthase

(2016) Muna A. Khan et al.   Frontiers in Microbiology

Bacterial antisense RNAs are mainly the product of transcriptional noise

(2016) V. Llorens-Rico et al.   Science Advances

Small Molecule Targeting of a MicroRNA Associated with Hepatocellular Carcinoma

(2015) Jessica L. Childs-Disney et al.   ACS Chemical Biology

Cross talk between ABC transporter mRNAs via a target mRNA-derived sponge of the GcvB small RNA

(2015) M. Miyakoshi et al.   EMBO JOURNAL

Differential transcriptional response to antibiotics byPseudomonas putida DOT-T1E

(2015) Carlos Molina-Santiago et al.   ENVIRONMENTAL MICROBIOLOGY

Systematic analysis of the role of bacterial Hfq-interacting sRNAs in the response to antibiotics

(2015) T. Kim et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

(Dis)similar Analogues of Riboswitch Metabolites as Antibacterial Lead Compounds

(2015) Daniel Matzner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of Bacterial Virulence by Csr (Rsm) Systems

(2015) Christopher A. Vakulskas et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A 3′ External Transcribed Spacer in a tRNA Transcript Acts as a Sponge for Small RNAs to Prevent Transcriptional Noise

(2015) David Lalaouna et al.   MOLECULAR CELL

Selective small-molecule inhibition of an RNA structural element

(2015) John A. Howe et al.   NATURE

Small RNA-based feedforward loop with AND-gate logic regulates extrachromosomal DNA transfer inSalmonella

(2015) Kai Papenfort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unexpected versatility in bacterial riboswitches

(2015) J.R. Mellin et al.   TRENDS IN GENETICS

RNA-binding proteins involved in post-transcriptional regulation in bacteria

(2015) Elke Van Assche et al.   Frontiers in Microbiology

Transcriptional Attenuation Controls Macrolide Inducible Efflux and Resistance in Streptococcus pneumoniae and in Other Gram-Positive Bacteria Containing mef/mel(msr(D)) Elements

(2015) Scott T. Chancey et al.   PLoS One

Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser315

(2015) Rose E. Jeeves et al.   PLoS One

Cell-Based Assay To Identify Inhibitors of the Hfq-sRNA Regulatory Pathway

(2014) Shaima A. El-Mowafi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential expression of small RNAs from Burkholderia thailandensis in response to varying environmental and stress conditions

(2014) Chris J Stubben et al.   BMC GENOMICS

MicL, a new  E-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein

(2014) M. S. Guo et al.   GENES & DEVELOPMENT

A small RNA controls a protein regulator involved in antibiotic resistance in Staphylococcus aureus

(2014) Alex Eyraud et al.   NUCLEIC ACIDS RESEARCH

The multidrug ABC transporter BmrC/BmrD of Bacillus subtilis is regulated via a ribosome-mediated transcriptional attenuation mechanism

(2014) Ewoud Reilman et al.   NUCLEIC ACIDS RESEARCH

Ménage à trois

(2014) Yvonne Göpel et al.   RNA Biology

Antibiotic drugs targeting bacterial RNAs

(2014) Weiling Hong et al.   Acta Pharmaceutica Sinica B

Analysis of the Small RNA Transcriptional Response in Multidrug-Resistant Staphylococcus aureus after Antimicrobial Exposure

(2013) Benjamin P. Howden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Integron attI1 Sites, Not Riboswitches, Associate with Antibiotic Resistance Genes

(2013) Adam Roth et al.   CELL

Riboswitch Control of Aminoglycoside Antibiotic Resistance

(2013) Xu Jia et al.   CELL

Antagonistic functions between the RNA chaperone Hfq and an sRNA regulate sensitivity to the antibiotic colicin

(2013) Hubert Salvail et al.   EMBO JOURNAL

The promise of riboswitches as potential antibacterial drug targets

(2013) Christina E. Lünse et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Control of RNA Stability by NrrF, an Iron-Regulated Small RNA in Neisseria gonorrhoeae

(2013) L. A. Jackson et al.   JOURNAL OF BACTERIOLOGY

Complex transcriptional and post-transcriptional regulation of an enzyme for lipopolysaccharide modification

(2013) Kyung Moon et al.   MOLECULAR MICROBIOLOGY

Riboswitch control of induction of aminoglycoside resistance acetyl and adenyl-transferases

(2013) Weizhi He et al.   RNA Biology

β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity

(2013) A. Gutierrez et al.   Nature Communications

Post-Transcriptional Control of the Escherichia coli PhoQ-PhoP Two-Component System by Multiple sRNAs Involves a Novel Pairing Region of GcvB

(2013) Audrey Coornaert et al.   PLoS Genetics

Tigecycline challenge triggers sRNA production in Salmonella enterica serovar Typhimurium

(2012) Jing Yu et al.   BMC MICROBIOLOGY

Acquired inducible antimicrobial resistance in Gram-positive bacteria

(2012) Scott T Chancey et al.   Future Microbiology

Experimental treatment of Staphylococcus aureus bovine intramammary infection using a guanine riboswitch ligand analog

(2012) C. Ster et al.   JOURNAL OF DAIRY SCIENCE

Azithromycin Inhibits Expression of the GacA-Dependent Small RNAs RsmY and RsmZ in Pseudomonas aeruginosa

(2011) Isabel Pérez-Martínez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Vibrio cholerae Triggers SOS and Mutagenesis in Response to a Wide Range of Antibiotics: a Route towards Multiresistance

(2011) Zeynep Baharoglu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transcription attenuation in bacteria: theme and variations

(2011) M. Naville et al.   Briefings in Functional Genomics

Antibiotic research in the age of omics: from expression profiles to interspecies communication

(2011) T. Wecke et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

cis-Antisense RNA, Another Level of Gene Regulation in Bacteria

(2011) J. Georg et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Regulation by Small RNAs in Bacteria: Expanding Frontiers

(2011) Gisela Storz et al.   MOLECULAR CELL

Competition among Hfq-binding small RNAs in Escherichia coli

(2011) Kyung Moon et al.   MOLECULAR MICROBIOLOGY

Hfq and its constellation of RNA

(2011) Jörg Vogel et al.   NATURE REVIEWS MICROBIOLOGY

Small RNAs endow a transcriptional activator with essential repressor functions for single-tier control of a global stress regulon

(2011) E. B. Gogol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Riboflavin analog Roseoflavin targets an FMN-riboswitch and blocksListeria monocytogenes growth, but also stimulates virulence gene-expression and infection

(2011) Mikael Mansjö et al.   RNA Biology

Small RNAs in the Genus Clostridium

(2011) Y. Chen et al.   mBio

Selection of Resistant Bacteria at Very Low Antibiotic Concentrations

(2011) Erik Gullberg et al.   PLoS Pathogens

Integrating anaerobic/aerobic sensing and the general stress response through the ArcZ small RNA

(2010) Pierre Mandin et al.   EMBO JOURNAL

Impact of the RNA chaperone Hfq on multidrug resistance in Escherichia coli

(2010) J. Yamada et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli

(2010) K. Nishino et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel Riboswitch Ligand Analogs as Selective Inhibitors of Guanine-Related Metabolic Pathways

(2010) Jérôme Mulhbacher et al.   PLoS Pathogens

Design and Antimicrobial Action of Purine Analogues That Bind Guanine Riboswitches

(2009) Jane N. Kim et al.   ACS Chemical Biology

Small regulatory non-coding RNAs in bacteria: physiology and mechanistic aspects

(2009) Francis Repoila et al.   BIOLOGY OF THE CELL

Role of the sRNA GcvB in regulation of cycA in Escherichia coli

(2009) S. C. Pulvermacher et al.   MICROBIOLOGY-SGM

Programmed drug-dependent ribosome stalling

(2009) Haripriya Ramu et al.   MOLECULAR MICROBIOLOGY

A PhoQ/P-regulated small RNA regulates sensitivity of Escherichia coli to antimicrobial peptides

(2009) Kyung Moon et al.   MOLECULAR MICROBIOLOGY

Specific and pleiotropic patterns of mRNA regulation by ArcZ, a conserved, Hfq-dependent small RNA

(2009) Kai Papenfort et al.   MOLECULAR MICROBIOLOGY

Riboswitch RNAs: using RNA to sense cellular metabolism

(2008) T. M. Henkin   GENES & DEVELOPMENT

Impact of the RNA Chaperone Hfq on the Fitness and Virulence Potential of Uropathogenic Escherichia coli

(2008) R. R. Kulesus et al.   INFECTION AND IMMUNITY