Mechanotransduction in tumor progression: The dark side of the force

Mechanosensing by the nucleus: From pathways to scaling relationships

(2017) Sangkyun Cho et al.   JOURNAL OF CELL BIOLOGY

Future cancer research priorities in the USA: a Lancet Oncology Commission

(2017) Elizabeth M Jaffee et al.   LANCET ONCOLOGY

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site

(2017) Y. A. Miroshnikova et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanical Stretching of Fibronectin Fibers Upregulates Binding of Interleukin-7

(2017) Daniela Ortiz Franyuti et al.   NANO LETTERS

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues

(2017) Wade W. Sugden et al.   NATURE CELL BIOLOGY

ROCK inhibition as a potential therapeutic target involved in apoptosis in hemangioma

(2017) Ming-Ke Qiu et al.   ONCOLOGY REPORTS

Matrix degradability controls multicellularity of 3D cell migration

(2017) Britta Trappmann et al.   Nature Communications

Fibronectin-guided migration of carcinoma collectives

(2017) Sandeep Gopal et al.   Nature Communications

Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation

(2017) Démosthène Mitrossilis et al.   Nature Communications

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

(2017) Alexandros Glentis et al.   Nature Communications

Atomic Force Microscopy micro-rheology reveals large structural inhomogeneities in single cell-nuclei

(2017) Michael Lherbette et al.   Scientific Reports

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Mechanical Stress Regulates Osteogenesis and Adipogenesis of Rat Mesenchymal Stem Cells through PI3K/Akt/GSK-3β/β-Catenin Signaling Pathway

(2017) Fanglong Song et al.   Biomed Research International

The interplay of stiffness and force anisotropies drives embryo elongation

(2017) Thanh Thi Kim Vuong-Brender et al.   eLife

Separate roles for chromatin and lamins in nuclear mechanics

(2017) Andrew D. Stephens et al.   Nucleus

Separate roles for chromatin and lamins in nuclear mechanics

(2017) Andrew D. Stephens et al.   Nucleus

Inside the Cell: Integrins as New Governors of Nuclear Alterations?

(2017) Elena Madrazo et al.   Cancers

Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status

(2017) Elise Kaspi et al.   PLoS One

From transformation to metastasis: deconstructing the extracellular matrix in breast cancer

(2016) Shelly Kaushik et al.   CANCER AND METASTASIS REVIEWS

YAP/TAZ as therapeutic targets in cancer

(2016) Francesca Zanconato et al.   CURRENT OPINION IN PHARMACOLOGY

Loss ofmiR-203regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness

(2016) Lily Thao-Nhi Le et al.   JOURNAL OF CELL BIOLOGY

Pushing, pulling, and squeezing our way to understanding mechanotransduction

(2016) Michael J. Siedlik et al.   METHODS

Micropost arrays for measuring stem cell-derived cardiomyocyte contractility

(2016) Kevin M. Beussman et al.   METHODS

Generating and characterizing the mechanical properties of cell-derived matrices using atomic force microscopy

(2016) Marta Tello et al.   METHODS

Using magnets and magnetic beads to dissect signaling pathways activated by mechanical tension applied to cells

(2016) R.J. Marjoram et al.   METHODS

Asymmetric division of contractile domains couples cell positioning and fate specification

(2016) Jean-Léon Maître et al.   NATURE

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

In vivo quantification of spatially varying mechanical properties in developing tissues

(2016) Friedhelm Serwane et al.   NATURE METHODS

Organoid culture systems for prostate epithelial and cancer tissue

(2016) Jarno Drost et al.   Nature Protocols

Matrix stiffening promotes a tumor vasculature phenotype

(2016) Francois Bordeleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis

(2016) Emily Steed et al.   Nature Communications

Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts

(2016) Stephanie Bonan et al.   Oncotarget

TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway

(2016) Roslin J. Thoppil et al.   Oncotarget

miR-33-5p, a novel mechano-sensitive microRNA promotes osteoblast differentiation by targeting Hmga2

(2016) Han Wang et al.   Scientific Reports

Dynamic interaction between actin and nesprin2 maintain the cell nucleus in a prestressed state

(2016) Abhishek Kumar et al.   Methods and Applications in Fluorescence

Under Pressure: Mechanical Stress Management in the Nucleus

(2016) Néjma Belaadi et al.   Cells

Tensile Forces Originating from Cancer Spheroids Facilitate Tumor Invasion

(2016) Katarzyna S. Kopanska et al.   PLoS One

Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer

(2016) Maria Nilsson et al.   Scientific Reports

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Constitutive Activation of Myosin-Dependent Contractility Sensitizes Glioma Tumor-Initiating Cells to Mechanical Inputs and Reduces Tissue Invasion

(2015) S. Y. Wong et al.   CANCER RESEARCH

Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer

(2015) Selwin K Wu et al.   CELL CYCLE

Buckling along boundaries of elastic contrast as a mechanism for early vertebrate morphogenesis

(2015) Vincent Fleury et al.   EUROPEAN PHYSICAL JOURNAL E

A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype

(2015) Luke Cassereau et al.   JOURNAL OF BIOTECHNOLOGY

Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma

(2015) D. Pankova et al.   MOLECULAR CANCER RESEARCH

Yes-associated protein regulates the growth of human non-small cell lung cancer in response to matrix stiffness

(2015) YONGGANG YUAN et al.   Molecular Medicine Reports

Apico-basal forces exerted by apoptotic cells drive epithelium folding

(2015) Bruno Monier et al.   NATURE

YAP is essential for tissue tension to ensure vertebrate 3D body shape

(2015) Sean Porazinski et al.   NATURE

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

(2015) María Elena Fernández-Sánchez et al.   NATURE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors

(2015) Francois Bordeleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Bioprinting for cancer research

(2015) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

Cancer cell migration in 3D tissue: Negotiating space by proteolysis and nuclear deformability

(2015) Marina Krause et al.   Cell Adhesion & Migration

Caveolae and cancer: A new mechanical perspective

(2015) Christophe Lamaze et al.   Biomedical Journal

Differential Predictive Roles of A- and B-Type Nuclear Lamins in Prostate Cancer Progression

(2015) Irena Saarinen et al.   PLoS One

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Increasing matrix stiffness upregulates vascular endothelial growth factor expression in hepatocellular carcinoma cells mediated by integrin β1

(2014) Yinying Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Compressive Stress Inhibits Proliferation in Tumor Spheroids through a Volume Limitation

(2014) Morgan Delarue et al.   BIOPHYSICAL JOURNAL

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue

(2014) J. Swift et al.   JOURNAL OF CELL SCIENCE

A mechanically-induced colon cancer cell population shows increased metastatic potential

(2014) Xin Tang et al.   Molecular Cancer

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression

(2014) Janna K Mouw et al.   NATURE MEDICINE

Fluid shear stress threshold regulates angiogenic sprouting

(2014) P. A. Galie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression

(2014) Youhua Tan et al.   Nature Communications

Flow shear stress regulates endothelial barrier function and expression of angiogenic factors in a 3D microfluidic tumor vascular model

(2014) Cara F Buchanan et al.   Cell Adhesion & Migration

Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion

(2013) Leanne Li et al.   CELL

Nuclear Mechanics and Mechanotransduction in Health and Disease

(2013) Philipp Isermann et al.   CURRENT BIOLOGY

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

External Mechanical Cues Trigger the Establishment of the Anterior-Posterior Axis in Early Mouse Embryos

(2013) Ryuji Hiramatsu et al.   DEVELOPMENTAL CELL

Interplay between the Dividing Cell and Its Neighbors Regulates Adherens Junction Formation during Cytokinesis in Epithelial Tissue

(2013) Sophie Herszterg et al.   DEVELOPMENTAL CELL

Modeling the tumor extracellular matrix: Tissue engineering tools repurposed towards new frontiers in cancer biology

(2013) Bartley J. Gill et al.   JOURNAL OF BIOMECHANICS

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Evaluation of single-cell biomechanics as potential marker for oral squamous cell carcinomas: a pilot study

(2013) J Runge et al.   ORAL DISEASES

Reduced Heart Rate and Cardiac Output Differentially Affect Angiogenesis, Growth, and Development in Early Chicken Embryos (Gallus domesticus)

(2013) Sylvia R. Branum et al.   PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

(2013) Thibaut Brunet et al.   Nature Communications

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

A tension-induced mechanotransduction pathway promotes epithelial morphogenesis

(2011) Huimin Zhang et al.   NATURE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail

(2011) Dan N. Simon et al.   Nucleus

Lamins as cancer biomarkers

(2010) Clare R. Foster et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Strength Dependence of Cadherin-Mediated Adhesions

(2010) Benoit Ladoux et al.   BIOPHYSICAL JOURNAL

Mechanical control of tissue and organ development

(2010) T. Mammoto et al.   DEVELOPMENT

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility

(2010) D Krndija et al.   ONCOGENE

Force-dependent polymorphism in type IV pili reveals hidden epitopes

(2010) N. Biais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Muscle Contraction Is Necessary to Maintain Joint Progenitor Cell Fate

(2009) Joy Kahn et al.   DEVELOPMENTAL CELL

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

Homeostatic competition drives tumor growth and metastasis nucleation

(2009) Markus Basan et al.   HFSP Journal

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Mechanical Signals Trigger Myosin II Redistribution and Mesoderm Invagination in Drosophila Embryos

(2009) P.-A. Pouille et al.   Science Signaling

Three-dimensional context regulation of metastasis

(2008) Janine T. Erler et al.   CLINICAL & EXPERIMENTAL METASTASIS

Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

(2008) Nicolas Desprat et al.   DEVELOPMENTAL CELL

Mechanical factors activate ß‐catenin‐dependent oncogene expression in APC1638N/+ mouse colon

(2008) Joanne Whitehead et al.   HFSP Journal

Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging

(2008) Cyrus M. Ghajar et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion

(2008) A. K. Fournier et al.   JOURNAL OF CELL SCIENCE

Close dependence of fibroblast proliferation on collagen scaffold matrix stiffness

(2008) E. Hadjipanayi et al.   Journal of Tissue Engineering and Regenerative Medicine

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neurosensory mechanotransduction

(2008) Martin Chalfie   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Developmental Patterning by Mechanical Signals in Arabidopsis

(2008) O. Hamant et al.   SCIENCE

New dimensions in tumor immunology: what does 3D culture reveal?

(2008) Chantal Feder-Mengus et al.   TRENDS IN MOLECULAR MEDICINE