Inside the Cell: Integrins as New Governors of Nuclear Alterations?

Increased chromatin plasticity supports enhanced metastatic potential of mouse melanoma cells

(2017) Yael Maizels et al.   EXPERIMENTAL CELL RESEARCH

Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins

(2017) Lisa M. Miller et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration

(2016) Xuan Cao et al.   BIOPHYSICAL JOURNAL

The complexity of integrins in cancer and new scopes for therapeutic targeting

(2016) Hellyeh Hamidi et al.   BRITISH JOURNAL OF CANCER

Cellular microenvironment controls the nuclear architecture of breast epithelia through β1-integrin

(2016) Apolinar Maya-Mendoza et al.   CELL CYCLE

Fascin Regulates Nuclear Movement and Deformation in Migrating Cells

(2016) Asier Jayo et al.   DEVELOPMENTAL CELL

Nucleolar organizer regions: genomic ‘dark matter’ requiring illumination

(2016) Brian McStay   GENES & DEVELOPMENT

Activating the nuclear piston mechanism of 3D migration in tumor cells

(2016) Ryan J. Petrie et al.   JOURNAL OF CELL BIOLOGY

Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains

(2016) Aneesh R. Sathe et al.   JOURNAL OF CELL SCIENCE

Growth Pattern in Paediatric Crohn Disease Is Related to Inflammatory Status

(2016) Delphine Ley et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Nuclear constriction segregates mobile nuclear proteins away from chromatin

(2016) Jerome Irianto et al.   MOLECULAR BIOLOGY OF THE CELL

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Nongenetic functions of the genome

(2016) M. Bustin et al.   SCIENCE

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

A neuronal network of mitochondrial dynamics regulates metastasis

(2016) M. Cecilia Caino et al.   Nature Communications

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

(2016) Hawa-Racine Thiam et al.   Nature Communications

Novel synthetic cyclic integrin αvβ3 binding peptide ALOS4: antitumor activity in mouse melanoma models

(2016) Shiri Yacobovich et al.   Oncotarget

Research advances on structure and biological functions of integrins

(2016) Li Pan et al.   SpringerPlus

Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II

(2015) Jonathan M. Page et al.   BIOMATERIALS

Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells

(2015) Yan-Jun Liu et al.   CELL

Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion

(2015) Inmaculada Navarro-Lérida et al.   DEVELOPMENTAL CELL

Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion

(2015) Dustin G. Thomas et al.   JOURNAL OF CELL BIOLOGY

Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells

(2015) F. M. Tonucci et al.   JOURNAL OF CELL SCIENCE

The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts

(2015) S. G. Alam et al.   JOURNAL OF CELL SCIENCE

Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma

(2015) Jiro Kikuchi et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo adhesion of malignant B cells to bone marrow microvasculature is regulated by α4β1 cytoplasmic-binding proteins

(2015) M Martínez-Moreno et al.   LEUKEMIA

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Force transmission during adhesion-independent migration

(2015) Martin Bergert et al.   NATURE CELL BIOLOGY

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

(2015) Merry Gunawan et al.   NATURE IMMUNOLOGY

Integrin α4β1 controls G9a activity that regulates epigenetic changes and nuclear properties required for lymphocyte migration

(2015) Xiaohong Zhang et al.   NUCLEIC ACIDS RESEARCH

Integrin α1β1 expression is controlled by c-MYC in colorectal cancer cells

(2015) S Boudjadi et al.   ONCOGENE

Nuclear deformability and telomere dynamics are regulated by cell geometric constraints

(2015) Ekta Makhija et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focal adhesion signaling and therapy resistance in cancer

(2015) Iris Eke et al.   SEMINARS IN CANCER BIOLOGY

Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

(2015) Laetitia Seguin et al.   TRENDS IN CELL BIOLOGY

Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells

(2015) Marta Nardella et al.   Oncotarget

Actomyosin Pulls to Advance the Nucleus in a Migrating Tissue Cell

(2014) Jun Wu et al.   BIOPHYSICAL JOURNAL

Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate

(2014) Matthew G. Rubashkin et al.   CANCER RESEARCH

Nuclear Stiffening Inhibits Migration of Invasive Melanoma Cells

(2014) Alexandre J. S. Ribeiro et al.   Cellular and Molecular Bioengineering

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

(2014) Patricia M. Davidson et al.   Cellular and Molecular Bioengineering

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells

(2014) M. H. Wilson et al.   DEVELOPMENT

Development of Drugs to Target Interactions Between Leukocytes and Endothelial Cells and Treatment Algorithms for Inflammatory Bowel Diseases

(2014) Silvio Danese et al.   GASTROENTEROLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Nuclear Role of WASp in Gene Transcription Is Uncoupled from Its ARP2/3-Dependent Cytoplasmic Role in Actin Polymerization

(2014) S. Sadhukhan et al.   JOURNAL OF IMMUNOLOGY

Strategies To Inhibit Tumor Associated Integrin Receptors: Rationale for Dual and Multi-Antagonists

(2014) Helen M. Sheldrake et al.   JOURNAL OF MEDICINAL CHEMISTRY

Miro-1 Links Mitochondria and Microtubule Dynein Motors To Control Lymphocyte Migration and Polarity

(2014) G. Morlino et al.   MOLECULAR AND CELLULAR BIOLOGY

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

STRIPAK components determine mode of cancer cell migration and metastasis

(2014) Chris D. Madsen et al.   NATURE CELL BIOLOGY

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

EZH2 Regulates Cofilin Activity and Colon Cancer Cell Migration by Targeting ITGA2 Gene

(2014) Angelo Ferraro et al.   PLoS One

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

5-Aza-2′-Deoxycytidine Enhances Maspin Expression and Inhibits Proliferation, Migration, and Invasion of the Bladder Cancer T24 Cell Line

(2013) Huihui Zhang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Cancer-associated upregulation of histone H3 lysine 9 trimethylation promotes cell motilityin vitroand drives tumor formationin vivo

(2013) Yuhki Yokoyama et al.   CANCER SCIENCE

Safety, tolerability, and pharmacokinetics of the novel αv-integrin antibody EMD 525797 (DI17E6) in healthy subjects after ascending single intravenous doses

(2013) Wolfgang Uhl et al.   INVESTIGATIONAL NEW DRUGS

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV

(2013) Michael G Overstreet et al.   NATURE IMMUNOLOGY

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Mechanical Regulation of Nuclear Structure and Function

(2012) Rui P. Martins et al.   Annual Review of Biomedical Engineering

FAK and p53 Protein Interactions

(2012) Vita M. Golubovskaya et al.   Anti-Cancer Agents in Medicinal Chemistry

Chromatin Decondensation and Nuclear Softening Accompany Nanog Downregulation in Embryonic Stem Cells

(2012) Kevin J. Chalut et al.   BIOPHYSICAL JOURNAL

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway

(2012) Lu Kong et al.   CARCINOGENESIS

Highlighting nuclear membrane staining in thyroid neoplasms with emerin: Review and diagnostic utility

(2012) Mary D. Kinsella et al.   DIAGNOSTIC CYTOPATHOLOGY

Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3

(2012) Bruno Cadot et al.   EMBO REPORTS

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex

(2012) Yu Wang et al.   JOURNAL OF CELL BIOLOGY

The ESCRT machinery mediates polarization of fibroblasts through regulation of myosin light chain

(2012) V. H. Lobert et al.   JOURNAL OF CELL SCIENCE

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting Epigenetic Readers in Cancer

(2012) Mark A. Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-invasive effects of decitabine, a DNA methyltransferase inhibitor, through tightening of tight junctions and inhibition of matrix metalloproteinase activities in AGS human gastric carcinoma cells

(2012) DONG YEOK SHIN et al.   ONCOLOGY REPORTS

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dynamic force-induced direct dissociation of protein complexes in a nuclear body in living cells

(2012) Yeh-Chuin Poh et al.   Nature Communications

Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis

(2011) Johanna Ivaska et al.   Annual Review of Cell and Developmental Biology

Sensing and Modulation of Invadopodia across a Wide Range of Rigidities

(2011) Aron Parekh et al.   BIOPHYSICAL JOURNAL

A randomised, phase II study of intetumumab, an anti-αv-integrin mAb, alone and with dacarbazine in stage IV melanoma

(2011) S O'Day et al.   BRITISH JOURNAL OF CANCER

A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer

(2011) Katherine M. Bell-McGuinn et al.   GYNECOLOGIC ONCOLOGY

Disconnecting the Golgi ribbon from the centrosome prevents directional cell migration and ciliogenesis

(2011) Lidia Hurtado et al.   JOURNAL OF CELL BIOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Subcellular Localization of SUN2 Is Regulated by Lamin A and Rab5

(2011) Ying Liang et al.   PLoS One

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Interactions Between Nuclei and the Cytoskeleton Are Mediated by SUN-KASH Nuclear-Envelope Bridges

(2010) Daniel A. Starr et al.   Annual Review of Cell and Developmental Biology

A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin αvβ3, ± dacarbazine in patients with stage IV metastatic melanoma

(2010) Peter Hersey et al.   CANCER

Matrix Metalloproteinase-9 Promotes Chronic Lymphocytic Leukemia B Cell Survival through Its Hemopexin Domain

(2010) Javier Redondo-Muñoz et al.   CANCER CELL

Efficient cell migration requires global chromatin condensation

(2010) G. Gerlitz et al.   JOURNAL OF CELL SCIENCE

Phosphorylated ezrin is located in the nucleus of the osteosarcoma cell

(2010) Claudio Di Cristofano et al.   MODERN PATHOLOGY

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Modulation of Cell Adhesion and Migration by the Histone Methyltransferase Subunit mDpy-30 and Its Interacting Proteins

(2010) Bin Xia et al.   PLoS One

The role of nuclear organization in cancer

(2009) Elliott Lever et al.   JOURNAL OF PATHOLOGY

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds  5 1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study

(2008) A. D. Ricart et al.   CLINICAL CANCER RESEARCH

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

(2008) Patrick T. Caswell et al.   JOURNAL OF CELL BIOLOGY

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

(2008) Ssang-Taek Lim et al.   MOLECULAR CELL

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE

Lamin A/C Is a Risk Biomarker in Colorectal Cancer

(2008) Naomi D. Willis et al.   PLoS One