Under Pressure: Mechanical Stress Management in the Nucleus

Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension

(2016) Paul T. Arsenovic et al.   BIOPHYSICAL JOURNAL

The nucleus is a conserved mechanosensation and mechanoresponse organelle

(2016) Alexandra P. Navarro et al.   Cytoskeleton

When cells push the envelope

(2016) B. Burke   SCIENCE

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

(2016) Hawa-Racine Thiam et al.   Nature Communications

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

A Disulfide Bond Is Required for the Transmission of Forces through SUN-KASH Complexes

(2015) Zeinab Jahed et al.   BIOPHYSICAL JOURNAL

Reinforcing the LINC complex connection to actin filaments: the role of FHOD1 in TAN line formation and nuclear movement

(2015) Susumu Antoku et al.   CELL CYCLE

Lamins at the crossroads of mechanosignaling

(2015) Selma Osmanagic-Myers et al.   GENES & DEVELOPMENT

Accessorizing and anchoring the LINC complex for multifunctionality

(2015) Wakam Chang et al.   JOURNAL OF CELL BIOLOGY

E-cadherin junctions as active mechanical integrators in tissue dynamics

(2015) Thomas Lecuit et al.   NATURE CELL BIOLOGY

Differential basal-to-apical accessibility of lamin A/C epitopes in the nuclear lamina regulated by changes in cytoskeletal tension

(2015) Teemu O. Ihalainen et al.   NATURE MATERIALS

SEPT12/SPAG4/LAMINB1 Complexes Are Required for Maintaining the Integrity of the Nuclear Envelope in Postmeiotic Male Germ Cells

(2015) Chung-Hsin Yeh et al.   PLoS One

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

(2015) Wakam Chang et al.   Nucleus

Nuclear mechanotransduction: Forcing the nucleus to respond

(2015) Christophe Guilluy et al.   Nucleus

The LINC complex component Sun4 plays a crucial role in sperm head formation and fertility

(2015) E. Pasch et al.   Biology Open

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

(2015) Wakam Chang et al.   Nucleus

Nuclear mechanotransduction: Forcing the nucleus to respond

(2015) Christophe Guilluy et al.   Nucleus

SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown

(2014) Yagmur Turgay et al.   JOURNAL OF CELL BIOLOGY

The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture

(2014) Natalie E. Cain et al.   JOURNAL OF CELL BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Cellular microenvironments reveal defective mechanosensing responses and elevated YAP signaling in LMNA-mutated muscle precursors

(2014) A. T. Bertrand et al.   JOURNAL OF CELL SCIENCE

Tight coupling between nucleus and cell migration through the perinuclear actin cap

(2014) D.-H. Kim et al.   JOURNAL OF CELL SCIENCE

FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement

(2014) Stefan Kutscheidt et al.   NATURE CELL BIOLOGY

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

LIM proteins in actin cytoskeleton mechanoresponse

(2014) M.A. Smith et al.   TRENDS IN CELL BIOLOGY

Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells

(2014) Caitlin Collins et al.   Nature Communications

SUN proteins and nuclear envelope spacing

(2014) Natalie E Cain et al.   Nucleus

Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis

(2013) Mirjam Ketema et al.   MOLECULAR BIOLOGY OF THE CELL

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Human haemodynamic frequency harmonics regulate the inflammatory phenotype of vascular endothelial cells

(2013) Ryan E. Feaver et al.   Nature Communications

Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment

(2012) Yubing Sun et al.   Annual Review of Biophysics

LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins

(2012) Brian A. Sosa et al.   CELL

Transcription factor regulation by mechanical stress

(2012) Melissa G. Mendez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling

(2012) Stephan Huveneers et al.   JOURNAL OF CELL BIOLOGY

Lamins at a glance

(2012) C. Y. Ho et al.   JOURNAL OF CELL SCIENCE

Mechanosensitive mechanisms in transcriptional regulation

(2012) Akiko Mammoto et al.   JOURNAL OF CELL SCIENCE

Cell Shape and Substrate Rigidity Both Regulate Cell Stiffness

(2011) Shang-You Tee et al.   BIOPHYSICAL JOURNAL

SPAG4L, a Novel Nuclear Envelope Protein Involved in the Meiotic Stage of Spermatogenesis

(2011) Xian-Zhen Jiang et al.   DNA AND CELL BIOLOGY

Structure of Sad1-UNC84 Homology (SUN) Domain Defines Features of Molecular Bridge in Nuclear Envelope

(2011) Zhaocai Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nesprin-3 augments peripheral nuclear localization of intermediate filaments in zebrafish

(2011) R. Postel et al.   JOURNAL OF CELL SCIENCE

Nucleoskeleton mechanics at a glance

(2011) K. N. Dahl et al.   JOURNAL OF CELL SCIENCE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues

(2011) Thomas Boudou et al.   TISSUE ENGINEERING PART A

The Classic: On the Inner Architecture of Bones and its Importance for Bone Growth

(2010) Julius Wolff   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development

(2010) Juehua Yu et al.   HUMAN MOLECULAR GENETICS

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Mammalian Sperm Head Formation Involves Different Polarization of Two Novel LINC Complexes

(2010) Eva Göb et al.   PLoS One

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Cell Mechanics: Dissecting the Physical Responses of Cells to Force

(2009) Brenton D. Hoffman et al.   Annual Review of Biomedical Engineering

Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections

(2009) David Razafsky et al.   JOURNAL OF CELL BIOLOGY

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton

(2009) H. R. Dawe et al.   JOURNAL OF CELL SCIENCE

Combined atomic force microscopy and side-view optical imaging for mechanical studies of cells

(2009) Ovijit Chaudhuri et al.   NATURE METHODS

Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

(2009) K. J. Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear mechanotransduction: Response of the lamina to extracellular stress with implications in aging

(2008) Julia T. Philip et al.   JOURNAL OF BIOMECHANICS

Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin

(2008) Y. Luke et al.   JOURNAL OF CELL SCIENCE

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY