Mechanisms driving the lactate switch in Chinese hamster ovary cells

Regulation of cell growth and apoptosis through lactate dehydrogenase C over-expression in Chinese hamster ovary cells

(2016) Tuo Fu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Warburg effect: 80 years on

(2016) Michelle Potter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Improving lactate metabolism in an intensified CHO culture process: productivity and product quality considerations

(2016) Sen Xu et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

(2016) Thomas E. Matthews et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic engineering of CHO cells to alter lactate metabolism during fed-batch cultures

(2016) Cécile Toussaint et al.   JOURNAL OF BIOTECHNOLOGY

An omics approach to rational feed

(2016) Eric J.M. Blondeel et al.   JOURNAL OF BIOTECHNOLOGY

Genetic analysis of the clonal stability of Chinese hamster ovary cells for recombinant protein production

(2016) Hongwen Li et al.   Molecular BioSystems

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

(2016) Hooman Hefzi et al.   Cell Systems

The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism

(2016) Bjørn Quistorff et al.   Aging-US

Lactate and glucose concomitant consumption as a self-regulated pH detoxification mechanism in HEK293 cell cultures

(2015) Leticia Liste-Calleja et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Advanced process monitoring and feedback control to enhance cell culture process production and robustness

(2015) An Zhang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness

(2015) Christopher A. Sellick et al.   Biotechnology Journal

Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process

(2015) Dénes Zalai et al.   BIOTECHNOLOGY PROGRESS

Elucidating the role of copper in CHO cell energy metabolism using13C metabolic flux analysis

(2015) Shilpa Nargund et al.   BIOTECHNOLOGY PROGRESS

The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor

(2015) Cara J. Valvona et al.   BRAIN PATHOLOGY

Glutaminolysis as a target for cancer therapy

(2015) L Jin et al.   ONCOGENE

Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness

(2015) Christopher A. Sellick et al.   Biotechnology Journal

Comparative Metabolic Analysis of CHO Cell Clones Obtained through Cell Engineering, for IgG Productivity, Growth and Cell Longevity

(2015) Camila A. Wilkens et al.   PLoS One

Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

(2014) Yuzhou Fan et al.   BIOTECHNOLOGY AND BIOENGINEERING

A framework for the systematic design of fed-batch strategies in mammalian cell culture

(2014) Sarantos Kyriakopoulos et al.   BIOTECHNOLOGY AND BIOENGINEERING

Elucidating the effects of postinduction glutamine feeding on the growth and productivity of CHO cells

(2014) Zahra Sheikholeslami et al.   BIOTECHNOLOGY PROGRESS

Effects of copper on CHO cells: Cellular requirements and product quality considerations

(2014) Inn H. Yuk et al.   BIOTECHNOLOGY PROGRESS

Manganese increases high mannose glycoform on monoclonal antibody expressed in CHO when glucose is absent or limiting: Implications for use of alternate sugars

(2014) Tanaya Surve et al.   BIOTECHNOLOGY PROGRESS

Effects of copper on CHO cells: Insights from gene expression analyses

(2014) Inn H. Yuk et al.   BIOTECHNOLOGY PROGRESS

Enhancement of production of protein biopharmaceuticals by mammalian cell cultures: the metabolomics perspective

(2014) Alan J Dickson   CURRENT OPINION IN BIOTECHNOLOGY

Proteomics analysis of altered cellular metabolism induced by insufficient copper level

(2014) Sohye Kang et al.   JOURNAL OF BIOTECHNOLOGY

Metabolic control at the cytosol–mitochondria interface in different growth phases of CHO cells

(2014) Judith Wahrheit et al.   METABOLIC ENGINEERING

The impact of anti-apoptotic gene Bcl-2∆ expression on CHO central metabolism

(2014) Neil Templeton et al.   METABOLIC ENGINEERING

Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform

(2014) Atefeh Ghorbaniaghdam et al.   PLoS One

Development of a fed-batch cultivation for antibody-producing cells based on combined feeding strategy of glucose and galactose

(2013) Ya-ting Sun et al.   BIOCHEMICAL ENGINEERING JOURNAL

Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition

(2013) Nuno Carinhas et al.   BIOTECHNOLOGY AND BIOENGINEERING

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture

(2013) Neil Templeton et al.   BIOTECHNOLOGY AND BIOENGINEERING

Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer

(2013) Di Zhao et al.   CANCER CELL

Metabolic flux rewiring in mammalian cell cultures

(2013) Jamey D Young   CURRENT OPINION IN BIOTECHNOLOGY

Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy

(2013) Ping Miao et al.   IUBMB LIFE

Dynamic gene expression for metabolic engineering of mammalian cells in culture

(2013) Huong Le et al.   METABOLIC ENGINEERING

Automated dynamic fed-batch process and media optimization for high productivity cell culture process development

(2012) Franklin Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption

(2012) Verónica S. Martínez et al.   BIOTECHNOLOGY AND BIOENGINEERING

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

(2012) Huong Le et al.   JOURNAL OF BIOTECHNOLOGY

On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

(2012) Bhanu Chandra Mulukutla et al.   METABOLIC ENGINEERING

What's fueling the biotech engine—2011 to 2012

(2012) Saurabh Aggarwal   NATURE BIOTECHNOLOGY

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

(2012) Francesca Zagari et al.   New Biotechnology

Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)

(2012) JIE ZHENG   Oncology Letters

High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures

(2011) Matthew Gagnon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

(2011) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Comparative metabolic analysis of lactate for CHO cells in glucose and galactose

(2011) Camila A. Wilkens et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells

(2011) Yueming Qian et al.   BIOTECHNOLOGY PROGRESS

Continuous CHO cell cultures with improved recombinant protein productivity by using mannose as carbon source: Metabolic analysis and scale-up simulation

(2011) Julio Berrios et al.   CHEMICAL ENGINEERING SCIENCE

The monocarboxylate transporter family-Role and regulation

(2011) Andrew P. Halestrap et al.   IUBMB LIFE

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases

(2011) Meixia Zhou et al.   JOURNAL OF BIOTECHNOLOGY

Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells

(2011) J. Fan et al.   MOLECULAR AND CELLULAR BIOLOGY

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio

(2011) B. Quistorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines

(2010) Haimanti Dorai et al.   BIOTECHNOLOGY PROGRESS

Mining manufacturing data for discovery of high productivity process characteristics

(2010) Salim Charaniya et al.   JOURNAL OF BIOTECHNOLOGY

Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: Overexpression of malate dehydrogenase II

(2010) William P.K. Chong et al.   JOURNAL OF BIOTECHNOLOGY

Dynamic model of CHO cell metabolism

(2010) Ryan P. Nolan et al.   METABOLIC ENGINEERING

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

(2010) J. M. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory crosstalk of the metabolic network

(2010) Nana-Maria Grüning et al.   TRENDS IN BIOCHEMICAL SCIENCES

Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture

(2009) Haimanti Dorai et al.   BIOTECHNOLOGY AND BIOENGINEERING

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

(2009) Ningning Ma et al.   BIOTECHNOLOGY PROGRESS

Expression of the Gene for Mouse Lactate Dehydrogenase C (Ldhc) Is Required for Male Fertility1

(2008) Fanny Odet et al.   BIOLOGY OF REPRODUCTION