Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness

Metabolic responses of CHO cells to limitation of key amino acids

(2014) Tiago M. Duarte et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic control at the cytosol–mitochondria interface in different growth phases of CHO cells

(2014) Judith Wahrheit et al.   METABOLIC ENGINEERING

Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition

(2013) Nuno Carinhas et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic analysis of antibody producing CHO cells in fed-batch production

(2013) Jason Dean et al.   BIOTECHNOLOGY AND BIOENGINEERING

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture

(2013) Neil Templeton et al.   BIOTECHNOLOGY AND BIOENGINEERING

Analysis of Chinese hamster ovary cell metabolism through a combined computational and experimental approach

(2013) Ning Chen et al.   CYTOTECHNOLOGY

Probing the metabolism of an inducible mammalian expression system using extracellular isotopomer analysis

(2013) Zahra Sheikholeslami et al.   JOURNAL OF BIOTECHNOLOGY

CHO Quasispecies—Implications for Manufacturing Processes

(2013) Florian Wurm   Processes

Metabolite profiling of CHO cells with different growth characteristics

(2012) Stefanie Dietmair et al.   BIOTECHNOLOGY AND BIOENGINEERING

LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells

(2012) William Pooi Kat Chong et al.   BIOTECHNOLOGY AND BIOENGINEERING

Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture

(2012) Suresh Selvarasu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption

(2012) Verónica S. Martínez et al.   BIOTECHNOLOGY AND BIOENGINEERING

On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

(2012) Bhanu Chandra Mulukutla et al.   METABOLIC ENGINEERING

Parallel labeling experiments with [1,2-13C]glucose and [U-13C]glutamine provide new insights into CHO cell metabolism

(2012) Woo Suk Ahn et al.   METABOLIC ENGINEERING

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

(2012) Francesca Zagari et al.   New Biotechnology

In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

(2012) Alireza Behjousiar et al.   PLoS One

Metabolite profiling of recombinant CHO cells: Designing tailored feeding regimes that enhance recombinant antibody production

(2011) Christopher A. Sellick et al.   BIOTECHNOLOGY AND BIOENGINEERING

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

(2011) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Correlation of antibody production rate with glucose and lactate metabolism in Chinese hamster ovary cells

(2011) Fei Chen et al.   BIOTECHNOLOGY LETTERS

Metabolite extraction from suspension-cultured mammalian cells for global metabolite profiling

(2011) Christopher A Sellick et al.   Nature Protocols

Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process

(2010) Marcella Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Strategies for selecting Recombinant CHO cell lines for cGMP manufacturing: Realizing the potential in bioreactors

(2010) Alison J. Porter et al.   BIOTECHNOLOGY PROGRESS

Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: Improving the efficiency of cell line generation

(2010) Alison J. Porter et al.   BIOTECHNOLOGY PROGRESS

Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: Overexpression of malate dehydrogenase II

(2010) William P.K. Chong et al.   JOURNAL OF BIOTECHNOLOGY

Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media

(2010) William P.K. Chong et al.   JOURNAL OF BIOTECHNOLOGY

Dynamic model of CHO cell metabolism

(2010) Ryan P. Nolan et al.   METABOLIC ENGINEERING

Evaluation of extraction processes for intracellular metabolite profiling of mammalian cells: matching extraction approaches to cell type and metabolite targets

(2010) Christopher A. Sellick et al.   Metabolomics

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

(2009) Ningning Ma et al.   BIOTECHNOLOGY PROGRESS

Effective Quenching Processes for Physiologically Valid Metabolite Profiling of Suspension Cultured Mammalian Cells

(2008) Christopher A. Sellick et al.   ANALYTICAL CHEMISTRY