Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

In-line and real-time prediction of recombinant antibody titer by in situ Raman spectroscopy

(2015) Silvère André et al.   ANALYTICA CHIMICA ACTA

Lactate and glucose concomitant consumption as a self-regulated pH detoxification mechanism in HEK293 cell cultures

(2015) Leticia Liste-Calleja et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Manufacturing process used to produce long-acting recombinant factor VIII Fc fusion protein

(2015) Justin McCue et al.   BIOLOGICALS

Advanced process monitoring and feedback control to enhance cell culture process production and robustness

(2015) An Zhang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

(2015) Brandon N. Berry et al.   BIOTECHNOLOGY PROGRESS

Generic Raman-based calibration models enabling real-time monitoring of cell culture bioreactors

(2015) Hamidreza Mehdizadeh et al.   BIOTECHNOLOGY PROGRESS

Insights into pH-induced metabolic switch by flux balance analysis

(2015) Marija Ivarsson et al.   BIOTECHNOLOGY PROGRESS

Advanced Development Strategies for Biopharmaceutical Cell Culture Processes

(2015) Denes Zalai et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Raman spectroscopy of complex defined media: biopharmaceutical applications

(2015) Gajendra P. Singh et al.   JOURNAL OF RAMAN SPECTROSCOPY

Quantitative monitoring of yeast fermentation using Raman spectroscopy

(2014) Jens A. Iversen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

(2014) Brandon Berry et al.   BIOTECHNOLOGY PROGRESS

Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller

(2014) Stephen Craven et al.   JOURNAL OF PROCESS CONTROL

Application of Multi-Omics Techniques for Bioprocess Design and Optimization in Chinese Hamster Ovary Cells

(2014) Amy Farrell et al.   JOURNAL OF PROTEOME RESEARCH

The challenge of applying Raman spectroscopy to monitor recombinant antibody production

(2013) Lorna Ashton et al.   ANALYST

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture

(2013) Neil Templeton et al.   BIOTECHNOLOGY AND BIOENGINEERING

Automated dynamic fed-batch process and media optimization for high productivity cell culture process development

(2012) Franklin Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors

(2012) Jessica Whelan et al.   BIOTECHNOLOGY PROGRESS

Raman spectroscopy and chemometrics foron-linecontrol of glucose fermentation bySaccharomyces cerevisiae

(2012) Thiago C. Ávila et al.   BIOTECHNOLOGY PROGRESS

Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

(2012) Huong Le et al.   JOURNAL OF BIOTECHNOLOGY

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

(2012) Francesca Zagari et al.   New Biotechnology

A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

(2012) Stefanie Dietmair et al.   PLoS One

Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance

(2011) Jincai Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures

(2011) Matthew Gagnon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry

(2011) Woo Suk Ahn et al.   METABOLIC ENGINEERING

Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase

(2011) Olivier Henry et al.   METABOLIC ENGINEERING

Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis

(2010) Olivier Henry et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Mining manufacturing data for discovery of high productivity process characteristics

(2010) Salim Charaniya et al.   JOURNAL OF BIOTECHNOLOGY