Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process

Progress toward forecasting product quality and quantity of mammalian cell culture processes by performance-based modeling

(2015) Timo Schmidberger et al.   BIOTECHNOLOGY PROGRESS

Insights into pH-induced metabolic switch by flux balance analysis

(2015) Marija Ivarsson et al.   BIOTECHNOLOGY PROGRESS

Advanced Development Strategies for Biopharmaceutical Cell Culture Processes

(2015) Denes Zalai et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

(2014) Marija Ivarsson et al.   JOURNAL OF BIOTECHNOLOGY

Metabolic control at the cytosol–mitochondria interface in different growth phases of CHO cells

(2014) Judith Wahrheit et al.   METABOLIC ENGINEERING

Differential Effect of Culture Temperature and Specific Growth Rate on CHO Cell Behavior in Chemostat Culture

(2014) Mauricio Vergara et al.   PLoS One

Dynamics of growth and metabolism controlled by glutamine availability in Chinese hamster ovary cells

(2013) Judith Wahrheit et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic analysis of antibody producing CHO cells in fed-batch production

(2013) Jason Dean et al.   BIOTECHNOLOGY AND BIOENGINEERING

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture

(2013) Neil Templeton et al.   BIOTECHNOLOGY AND BIOENGINEERING

Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption

(2012) Verónica S. Martínez et al.   BIOTECHNOLOGY AND BIOENGINEERING

A review of variable selection methods in Partial Least Squares Regression

(2012) Tahir Mehmood et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

(2012) Bhanu Chandra Mulukutla et al.   METABOLIC ENGINEERING

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

(2012) Francesca Zagari et al.   New Biotechnology

Effects of culture temperature and pH on flag-tagged COMP angiopoietin-1 (FCA1) production from recombinant CHO cells: FCA1 aggregation

(2011) Su-Jeong Hwang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

(2011) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Towards dynamic metabolic flux analysis in CHO cell cultures

(2011) Woo Suk Ahn et al.   Biotechnology Journal

Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry

(2011) Woo Suk Ahn et al.   METABOLIC ENGINEERING

Optimizing amino acid composition of CHO cell culture media for a fusion protein production

(2011) Zizhuo Xing et al.   PROCESS BIOCHEMISTRY

Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis

(2010) Jens Niklas et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Effect of temperature, pH, dissolved oxygen, and hydrolysate on the formation of triple light chain antibodies in cell culture

(2010) Natalia Gomez et al.   BIOTECHNOLOGY PROGRESS

Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes

(2010) Srinivas Karra et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Dynamic model of CHO cell metabolism

(2010) Ryan P. Nolan et al.   METABOLIC ENGINEERING

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

(2009) Ningning Ma et al.   BIOTECHNOLOGY PROGRESS

Modeling Hybridoma Cell Metabolism Using a Generic Genome-Scale Metabolic Model of Mus musculus

(2005) Kashif Sheikh et al.   BIOTECHNOLOGY PROGRESS