A framework for the systematic design of fed-batch strategies in mammalian cell culture

What's fueling the biotech engine—2012 to 2013

(2014) Saurabh (Rob) Aggarwal   NATURE BIOTECHNOLOGY

ETA: Robust software for determination of cell specific rates from extracellular time courses

(2013) Taylor A. Murphy et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition

(2013) Nuno Carinhas et al.   BIOTECHNOLOGY AND BIOENGINEERING

Fermentanomics informed amino acid supplementation of an antibody producing mammalian cell culture

(2013) Erik K. Read et al.   BIOTECHNOLOGY PROGRESS

The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

(2013) Helene Faustrup Kildegaard et al.   CURRENT OPINION IN BIOTECHNOLOGY

Comparative analysis of amino acid metabolism and transport in CHO variants with different levels of productivity

(2013) Sarantos Kyriakopoulos et al.   JOURNAL OF BIOTECHNOLOGY

Application of improved top-down approach in maximizing CHO cell mass and productivity in fed-batch culture

(2013) Ya-Ting Sun et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

A high-throughput media design approach for high performance mammalian fed-batch cultures

(2013) Yolande Rouiller et al.   mAbs

The dynamics of the CHO host cell protein profile during clarification and protein A capture in a platform antibody purification process

(2012) Catherine E.M. Hogwood et al.   BIOTECHNOLOGY AND BIOENGINEERING

Automated dynamic fed-batch process and media optimization for high productivity cell culture process development

(2012) Franklin Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture

(2012) Suresh Selvarasu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption

(2012) Verónica S. Martínez et al.   BIOTECHNOLOGY AND BIOENGINEERING

Fed-batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty

(2012) James Pollock et al.   BIOTECHNOLOGY AND BIOENGINEERING

Eliminating tyrosine sequence variants in CHO cell lines producing recombinant monoclonal antibodies

(2012) Lauren Feeney et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolomics profiling of extracellular metabolites in CHO-K1 cells cultured in different types of growth media

(2012) Salfarina Ezrina Mohmad-Saberi et al.   CYTOTECHNOLOGY

Development of optimal medium for production of commercially important monoclonal antibody 520C9 by hybridoma cell

(2012) Sucharita Sen et al.   CYTOTECHNOLOGY

Cell culture medium improvement by rigorous shuffling of components using media blending

(2012) Martin Jordan et al.   CYTOTECHNOLOGY

Rational development of a serum-free medium and fed-batch process for a GS-CHO cell line expressing recombinant antibody

(2012) Huifeng Zhang et al.   CYTOTECHNOLOGY

Analysis of the landscape of biologically-derived pharmaceuticals in Europe: Dominant production systems, molecule types on the rise and approval trends

(2012) Sarantos Kyriakopoulos et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

(2012) Huong Le et al.   JOURNAL OF BIOTECHNOLOGY

On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

(2012) Bhanu Chandra Mulukutla et al.   METABOLIC ENGINEERING

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

(2012) Francesca Zagari et al.   New Biotechnology

Genomics in mammalian cell culture bioprocessing

(2011) Diane M. Wuest et al.   BIOTECHNOLOGY ADVANCES

Metabolite profiling of recombinant CHO cells: Designing tailored feeding regimes that enhance recombinant antibody production

(2011) Christopher A. Sellick et al.   BIOTECHNOLOGY AND BIOENGINEERING

Host cell protein dynamics in the supernatant of a mAb producing CHO cell line

(2011) A.S. Tait et al.   BIOTECHNOLOGY AND BIOENGINEERING

Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance

(2011) Jincai Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

(2011) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Manufacturing recombinant proteins in kg-ton quantities using animal cells in bioreactors

(2011) Maria De Jesus et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Computational approach for understanding and improving GS-NS0 antibody production under hyperosmotic conditions

(2011) Yingswan Ho et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process

(2010) Marcella Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

A fully defined, fed-batch, recombinant NS0 culture process for monoclonal antibody production

(2010) Paul A. Hermes et al.   BIOTECHNOLOGY PROGRESS

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

(2009) Ningning Ma et al.   BIOTECHNOLOGY PROGRESS

Metabolic flux analysis in mammalian cell culture

(2009) Lake-Ee Quek et al.   METABOLIC ENGINEERING

Genome-scale modeling and in silico analysis of mouse cell metabolic network

(2009) Suresh Selvarasu et al.   Molecular BioSystems