Effects of copper on CHO cells: Insights from gene expression analyses

Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell

(2013) Zhilan Hu et al.   BIOTECHNOLOGY PROGRESS

Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption

(2012) Verónica S. Martínez et al.   BIOTECHNOLOGY AND BIOENGINEERING

Consistency Test of the Cell Cycle: Roles for p53 and EGR1

(2012) Y. Zwang et al.   CANCER RESEARCH

Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors

(2012) Wei-Ting Hsu et al.   CYTOTECHNOLOGY

Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

(2012) Huong Le et al.   JOURNAL OF BIOTECHNOLOGY

Intrapulmonary Administration of Leukotriene B4 Augments Neutrophil Accumulation and Responses in the Lung to Klebsiella Infection in CXCL1 Knockout Mice

(2012) S. Batra et al.   JOURNAL OF IMMUNOLOGY

On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

(2012) Bhanu Chandra Mulukutla et al.   METABOLIC ENGINEERING

A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

(2012) M. L. Turski et al.   MOLECULAR AND CELLULAR BIOLOGY

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

(2012) Francesca Zagari et al.   New Biotechnology

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

(2011) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells

(2011) Yueming Qian et al.   BIOTECHNOLOGY PROGRESS

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

The Myc-ARF-Egr1 pathway

(2011) David N. Boone et al.   CELL CYCLE

Inhibition of Glycolytic Enzymes Mediated by Pharmacologically Activated p53

(2011) Joanna Zawacka-Pankau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases

(2011) Meixia Zhou et al.   JOURNAL OF BIOTECHNOLOGY

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression

(2011) M-T Lau et al.   ONCOGENE

Second AKT: The rise of SGK in cancer signalling

(2010) Maressa A. Bruhn et al.   GROWTH FACTORS

Placenta Growth Factor-induced Early Growth Response 1 (Egr-1) Regulates Hypoxia-inducible Factor-1α (HIF-1α) in Endothelial Cells

(2010) Nitin Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin

(2010) Joerg Kumbrink et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation

(2010) David U. Mick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactome: a database of reactions, pathways and biological processes

(2010) D. Croft et al.   NUCLEIC ACIDS RESEARCH

Developing genomic platforms for Chinese hamster ovary cells

(2009) Anne Kantardjieff et al.   BIOTECHNOLOGY ADVANCES

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

(2009) Ningning Ma et al.   BIOTECHNOLOGY PROGRESS

Estimating accuracy of RNA-Seq and microarrays with proteomics

(2009) Xing Fu et al.   BMC GENOMICS

Is EGR1 a potential target for prostate cancer therapy?

(2009) Delphine Gitenay et al.   Future Oncology

Copper Activation of NF-κB Signaling in HepG2 Cells

(2009) Matthew K. McElwee et al.   JOURNAL OF MOLECULAR BIOLOGY

A Key Role for Early Growth Response-1 and Nuclear Factor- B in Mediating and Maintaining GRO/CXCR2 Proliferative Signaling in Esophageal Cancer

(2009) B. Wang et al.   MOLECULAR CANCER RESEARCH

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

(2009) Min Ok Song et al.   PHYSIOLOGICAL GENOMICS

Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells

(2009) Olivier Feron   RADIOTHERAPY AND ONCOLOGY

Novel Role of Antioxidant-1 (Atox1) as a Copper-dependent Transcription Factor Involved in Cell Proliferation

(2008) Shinichi Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Egr1 andGas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates

(2007) Pratik Jaluria et al.   BIOTECHNOLOGY AND BIOENGINEERING