Improving lactate metabolism in an intensified CHO culture process: productivity and product quality considerations

Concentrated fed-batch cell culture increases manufacturing capacity without additional volumetric capacity

(2016) William C. Yang et al.   JOURNAL OF BIOTECHNOLOGY

Mechanism for multiplicity of steady states with distinct cell concentration in continuous culture of mammalian cells

(2015) Andrew Yongky et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell culture media supplementation of bioflavonoids for the targeted reduction of acidic species charge variants on recombinant therapeutic proteins

(2015) Patrick Hossler et al.   BIOTECHNOLOGY PROGRESS

Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture

(2015) Shohei Kishishita et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Multiplicity of Steady States in Glycolysis and Shift of Metabolic State in Cultured Mammalian Cells

(2015) Bhanu Chandra Mulukutla et al.   PLoS One

Effects of copper on CHO cells: Cellular requirements and product quality considerations

(2014) Inn H. Yuk et al.   BIOTECHNOLOGY PROGRESS

Proteomics analysis of altered cellular metabolism induced by insufficient copper level

(2014) Sohye Kang et al.   JOURNAL OF BIOTECHNOLOGY

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture

(2013) Neil Templeton et al.   BIOTECHNOLOGY AND BIOENGINEERING

CHO cell line specific prediction and control of recombinant monoclonal antibodyN-glycosylation

(2013) Rhian K. Grainger et al.   BIOTECHNOLOGY AND BIOENGINEERING

Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process

(2013) Marie-Françoise Clincke et al.   BIOTECHNOLOGY PROGRESS

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

(2013) S. Ishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automated dynamic fed-batch process and media optimization for high productivity cell culture process development

(2012) Franklin Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Integrated continuous production of recombinant therapeutic proteins

(2012) Veena Warikoo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

(2012) Francesca Zagari et al.   New Biotechnology

Effect of process change from perfusion to fed-batch on product comparability for biosimilar monoclonal antibody

(2012) Soo-Young Lee et al.   PROCESS BIOCHEMISTRY

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

(2011) Michael J. Gramer et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures

(2011) Matthew Gagnon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

(2011) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells

(2011) Yueming Qian et al.   BIOTECHNOLOGY PROGRESS

Continuous CHO cell cultures with improved recombinant protein productivity by using mannose as carbon source: Metabolic analysis and scale-up simulation

(2011) Julio Berrios et al.   CHEMICAL ENGINEERING SCIENCE

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Mining manufacturing data for discovery of high productivity process characteristics

(2010) Salim Charaniya et al.   JOURNAL OF BIOTECHNOLOGY

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

(2009) Ningning Ma et al.   BIOTECHNOLOGY PROGRESS

Effects of Elevated pCO2 and Osmolality on Growth of CHO Cells and Production of Antibody-Fusion Protein B1: A Case Study

(2005) Marie M. Zhu et al.   BIOTECHNOLOGY PROGRESS