GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia

Phase-amplitude coupled persistent theta and gamma oscillations in rat primary motor cortex in vitro

(2017) Nicholas W. Johnson et al.   NEUROPHARMACOLOGY

Neuroprotective role of GABA B receptor modulation against streptozotocin-induced behavioral and biochemical abnormalities in rats

(2017) Kushal Kumar et al.   NEUROSCIENCE

HDAC1 links early life stress to schizophrenia-like phenotypes

(2017) Sanaz Bahari-Javan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington’s disease mice

(2017) Nuria Suelves et al.   Scientific Reports

Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial

(2017) Robert K. Naviaux et al.   Annals of Clinical and Translational Neurology

Baclofen ameliorates spatial working memory impairments induced by chronic cerebral hypoperfusion via up-regulation of HCN2 expression in the PFC in rats

(2016) Pan Luo et al.   BEHAVIOURAL BRAIN RESEARCH

Caution When Diagnosing Your Mouse With Schizophrenia: The Use and Misuse of Model Animals for Understanding Psychiatric Disorders

(2016) Albert H.C. Wong et al.   BIOLOGICAL PSYCHIATRY

Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration

(2016) Shabir Ahmad Ganai et al.   Current Neuropharmacology

Histone Modification of Nedd4 Ubiquitin Ligase Controls the Loss of AMPA Receptors and Cognitive Impairment Induced by Repeated Stress

(2016) J. Wei et al.   JOURNAL OF NEUROSCIENCE

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer’s Disease Mice

(2016) Mar Cuadrado-Tejedor et al.   NEUROPSYCHOPHARMACOLOGY

Role of GABAB receptors in learning and memory and neurological disorders

(2016) Chelcie F. Heaney et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Effect of Sodium Valproate on Cognitive Function and Hippocampus of Rats After Convulsive Status Epilepticus

(2016) Peng Wu et al.   MEDICAL SCIENCE MONITOR

Increased GABAB receptor signaling in a rat model for schizophrenia

(2016) Martijn M. Selten et al.   Scientific Reports

The Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor (α7 nAChR) Agonists for the Treatment of the Cognitive Deficits Associated with Schizophrenia

(2015) Corinne Beinat et al.   CNS DRUGS

The Role of the Human Entorhinal Cortex in a Representational Account of Memory

(2015) Heidrun Schultz et al.   Frontiers in Human Neuroscience

Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation

(2015) K. M. Bieszczad et al.   JOURNAL OF NEUROSCIENCE

Negative modulation of α5 GABAA receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion

(2015) Tamara Timić Stamenić et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Prospects for the development of epigenetic drugs for CNS conditions

(2015) Moshe Szyf   NATURE REVIEWS DRUG DISCOVERY

Gender-specific effects of CGP 55845, GABAB receptor antagonist, on neuromuscular coordination, learning and memory formation in albino mouse following neonatal hypoxia–ischemia insult

(2015) Quratul Ane Gillani et al.   NEUROLOGICAL SCIENCES

Parvalbumin Interneurons of Hippocampus Tune Population Activity at Theta Frequency

(2015) Bénédicte Amilhon et al.   NEURON

Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia

(2015) Andrew J. Pocklington et al.   NEURON

Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue

(2015) Gavin Rumbaugh et al.   NEUROPSYCHOPHARMACOLOGY

The effect of GABA transporter 1 (GAT1) inhibitor, tiagabine, on scopolamine-induced memory impairments in mice

(2015) Kinga Sałat et al.   Pharmacological Reports

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

(2015) F. F. Wagner et al.   Chemical Science

Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model

(2015) Jane C Naviaux et al.   Molecular Autism

Schizophrenia

(2015) René S. Kahn et al.   Nature Reviews Disease Primers

HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?

(2014) Nigel Whittle et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

(2014) Johannes Gräff et al.   CELL

Sodium Butyrate Functions as an Antidepressant and Improves Cognition with Enhanced Neurotrophic Expression in Models of Maternal Deprivation and Chronic Mild Stress

(2014) Samira Valvassori et al.   CURRENT NEUROVASCULAR RESEARCH

The Role of α5 GABAA Receptor Agonists in the Treatment of Cognitive Deficits in Schizophrenia

(2014) Kathryn Gill et al.   CURRENT PHARMACEUTICAL DESIGN

Reassessing the effects of histone deacetylase inhibitors on hippocampal memory and cognitive aging

(2014) James F. Castellano et al.   HIPPOCAMPUS

Highly Energized Inhibitory Interneurons are a Central Element for Information Processing in Cortical Networks

(2014) Oliver Kann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Histone Deacetylase Inhibitor, Trichostatin A, Improves Learning and Memory in High-Fat Diet-Induced Cognitive Deficits in Mice

(2014) Sorabh Sharma et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Effects of intrahippocampal GABAB receptor antagonist treatment on the behavioral long-term potentiation and Y-maze learning performance

(2014) Qi-Yao Liu et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Neurodevelopment, GABA System Dysfunction and Schizophrenia

(2014) Martin J Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

(2014) Kazuhiro Takuma et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation

(2014) Aline Rideau Batista Novais et al.   PLoS One

Neurodevelopmental origin of cognitive impairment in schizophrenia

(2014) E. Bora   PSYCHOLOGICAL MEDICINE

Early Developmental Disturbances of Cortical Inhibitory Neurons: Contribution to Cognitive Deficits in Schizophrenia

(2014) D. W. Volk et al.   SCHIZOPHRENIA BULLETIN

CGP 35348, GABABReceptor Antagonist, Has a Potential to Improve Neuromuscular Coordination and Spatial Learning in Albino Mouse following Neonatal Brain Damage

(2014) Q. Gillani et al.   Biomed Research International

Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy

(2014) J C Naviaux et al.   Translational Psychiatry

Histone-acetylation: a link between Alzheimer's disease and post-traumatic stress disorder?

(2014) Sanaz Bahari-Javan et al.   Frontiers in Neuroscience

GABA level, gamma oscillation, and working memory performance in schizophrenia

(2014) Chi-Ming A. Chen et al.   NeuroImage-Clinical

The Potential of HDAC Inhibitors as Cognitive Enhancers

(2013) Johannes Gräff et al.   Annual Review of Pharmacology and Toxicology

Treating Working Memory Deficits in Schizophrenia: A Review of the Neurobiology

(2013) Tristram A. Lett et al.   BIOLOGICAL PSYCHIATRY

GAD67 Deficiency in Parvalbumin Interneurons Produces Deficits in Inhibitory Transmission and Network Disinhibition in Mouse Prefrontal Cortex

(2013) M. S. Lazarus et al.   CEREBRAL CORTEX

Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia

(2013) David A Lewis   CURRENT OPINION IN NEUROBIOLOGY

Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors

(2013) Alkomiet Hasan et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Altered parvalbumin basket cell inputs in the dorsolateral prefrontal cortex of schizophrenia subjects

(2013) J R Glausier et al.   MOLECULAR PSYCHIATRY

EEG and MEG: Relevance to Neuroscience

(2013) Fernando Lopes da Silva   NEURON

Allosteric Modulation of GABAA Receptor Subtypes: Effects on Visual Recognition and Visuospatial Working Memory in Rhesus Monkeys

(2013) Paul L Soto et al.   NEUROPSYCHOPHARMACOLOGY

Cognition-impairing effects of benzodiazepine-type drugs: Role of GABAA receptor subtypes in an executive function task in rhesus monkeys

(2013) Leah Makaron et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition

(2013) Jesse E. Hanson et al.   PLoS One

Disrupting the clustering of GABAA receptor  2 subunits in the frontal cortex leads to reduced  -power and cognitive deficits

(2013) R. M. Hines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging neurotrophic role of GABAB receptors in neuronal circuit development

(2013) Jean-Luc Gaiarsa et al.   Frontiers in Cellular Neuroscience

Ketamine alters oscillatory coupling in the hippocampus

(2013) Fábio V. Caixeta et al.   Scientific Reports

Development and specification of GABAergic cortical interneurons

(2013) Corey Kelsom et al.   Cell and Bioscience

Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice

(2013) Frankie HF Lee et al.   Molecular Brain

Schizophrenia Is a Cognitive Illness

(2013) René S. Kahn et al.   JAMA Psychiatry

PWZ-029, an inverse agonist selective for α5 GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats

(2012) Marija Milić et al.   BEHAVIOURAL BRAIN RESEARCH

High-Frequency Oscillations in Schizophrenia

(2012) Peter J. Uhlhaas   CLINICAL EEG AND NEUROSCIENCE

Mercaptoacetamide-based class II HDAC inhibitor lowers Aβ levels and improves learning and memory in a mouse model of Alzheimer's disease

(2012) You Me Sung et al.   EXPERIMENTAL NEUROLOGY

Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin–proteasomal and autophagy systems

(2012) Haiqun Jia et al.   HUMAN MOLECULAR GENETICS

Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition

(2012) Reecha D. Shah et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

BL-1020, a New γ-Aminobutyric Acid–Enhanced Antipsychotic

(2012) Yona Geffen et al.   JOURNAL OF CLINICAL PSYCHIATRY

Deficits in Cognition and Synaptic Plasticity in a Mouse Model of Down Syndrome Ameliorated by GABAB Receptor Antagonists

(2012) A. M. Kleschevnikov et al.   JOURNAL OF NEUROSCIENCE

Cortical basket cell dysfunction in schizophrenia

(2012) Allison A. Curley et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synaptic scaffold evolution generated components of vertebrate cognitive complexity

(2012) Jess Nithianantharajah et al.   NATURE NEUROSCIENCE

Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease

(2012) Stephen G. Brickley et al.   NEURON

The histone deacetylase inhibitor, sodium butyrate, alleviates cognitive deficits in pre-motor stage PD

(2012) Pallavi Rane et al.   NEUROPHARMACOLOGY

Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

(2012) Daniel M. Fass et al.   NEUROPHARMACOLOGY

Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model

(2012) Nigel Whittle et al.   NEUROPHARMACOLOGY

Genetic Strain Differences in Learned Fear Inhibition Associated with Variation in Neuroendocrine, Autonomic and Amygdala Dendritic Phenotypes

(2012) Marguerite C Camp et al.   NEUROPSYCHOPHARMACOLOGY

The Role of Histone Acetylation in Memory Formation and Cognitive Impairments

(2012) Lucia Peixoto et al.   NEUROPSYCHOPHARMACOLOGY

α2-containing GABAA receptors: A target for the development of novel treatment strategies for CNS disorders

(2012) Elif Engin et al.   PHARMACOLOGY & THERAPEUTICS

The role of glutamatergic inputs onto parvalbumin-positive interneurons: relevance for schizophrenia

(2012) Diana C. Rotaru et al.   REVIEWS IN THE NEUROSCIENCES

Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice

(2011) Jesse C. Wiley et al.   AGING CELL

Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats

(2011) Gustavo K. Reolon et al.   BEHAVIOURAL BRAIN RESEARCH

Perisomatic inhibition and cortical circuit dysfunction in schizophrenia

(2011) David A Lewis et al.   CURRENT OPINION IN NEUROBIOLOGY

GABAA Receptor Subtype-Selective Modulators. II. α5-Selective Inverse Agonists for Cognition Enhancement

(2011) John R. Atack   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease

(2011) Wenbo Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

(2011) S. C. McQuown et al.   JOURNAL OF NEUROSCIENCE

Downregulation of Parvalbumin at Cortical GABA Synapses Reduces Network Gamma Oscillatory Activity

(2011) V. Volman et al.   JOURNAL OF NEUROSCIENCE

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

GABAergic interneuron origin of schizophrenia pathophysiology

(2011) Kazu Nakazawa et al.   NEUROPHARMACOLOGY

A Novel α5GABAAR-Positive Allosteric Modulator Reverses Hyperactivation of the Dopamine System in the MAM Model of Schizophrenia

(2011) Kathryn M Gill et al.   NEUROPSYCHOPHARMACOLOGY

Alpha7 Nicotinic Acetylcholine Receptors Modulate Motivation to Self-Administer Nicotine: Implications for Smoking and Schizophrenia

(2011) Darlene H Brunzell et al.   NEUROPSYCHOPHARMACOLOGY

Gamma Oscillation in Schizophrenia

(2011) Yong-Wook Shin et al.   Psychiatry Investigation

Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats

(2011) John P. Redrobe et al.   PSYCHOPHARMACOLOGY

High vs Low Frequency Neural Oscillations in Schizophrenia

(2011) L. V. Moran et al.   SCHIZOPHRENIA BULLETIN

Deficits in GABAB receptor system in schizophrenia and mood disorders: A postmortem study

(2011) S. Hossein Fatemi et al.   SCHIZOPHRENIA RESEARCH

Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia

(2011) David A. Lewis et al.   TRENDS IN NEUROSCIENCES

Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia

(2011) Daniel J. Lodge et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Role for GAT-1 in Presynaptic GABA Homeostasis?

(2011) Fiorenzo Conti et al.   Frontiers in Cellular Neuroscience

The HDAC Inhibitor Phenylbutyrate Reverses Effects of Neonatal Ventral Hippocampal Lesion in Rats

(2011) Guy Sandner et al.   Frontiers in Psychiatry

A Randomized Clinical Trial of MK-0777 for the Treatment of Cognitive Impairments in People with Schizophrenia

(2010) Robert W. Buchanan et al.   BIOLOGICAL PSYCHIATRY

The GABAB receptor as a target for antidepressant drug action

(2010) Subroto Ghose et al.   BRITISH JOURNAL OF PHARMACOLOGY

The chandelier neuron in schizophrenia

(2010) David A. Lewis   Developmental Neurobiology

Multiple origins of the cortical gamma rhythm

(2010) Miles A. Whittington et al.   Developmental Neurobiology

The inhibitory GABA system as a therapeutic target for cognitive symptoms in schizophrenia: investigational agents in the pipeline

(2010) Christiaan H Vinkers et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Early signs, diagnosis and therapeutics of the prodromal phase of schizophrenia and related psychotic disorders

(2010) Molly K Larson et al.   Expert Review of Neurotherapeutics

Allosteric Modulation of Related Ligand-Gated Ion Channels Synergistically Induces Long-Term Potentiation in the Hippocampus and Enhances Cognition

(2010) T. B. Johnstone et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling

(2010) Pietro Fazzari et al.   NATURE

Abnormal neural oscillations and synchrony in schizophrenia

(2010) Peter J. Uhlhaas et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic GABAergic targets in schizophrenia and bipolar disorder

(2010) A. Guidotti et al.   NEUROPHARMACOLOGY

Functional role of gamma and theta oscillations in episodic memory

(2010) Erika Nyhus et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Targeting the correct HDAC(s) to treat cognitive disorders

(2010) André Fischer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Alterations of Cortical GABA Neurons and Network Oscillations in Schizophrenia

(2010) Guillermo Gonzalez-Burgos et al.   Current Psychiatry Reports

Drug development for Alzheimer's disease: Where are we now and where are we headed?

(2009) Marwan N. Sabbagh   American Journal Geriatric Pharmacotherapy

The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction

(2009) Henner Knust et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The molecular pathology of schizophrenia—Focus on histone and DNA modifications

(2009) Schahram Akbarian   BRAIN RESEARCH BULLETIN

GABAB Receptors, Schizophrenia and Sleep Dysfunction

(2009) Joshua Kantrowitz et al.   CNS DRUGS

P50 sensory gating is related to performance on select tasks of cognitive inhibition

(2009) Carly A. Yadon et al.   COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE

Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function

(2009) D. Belelli et al.   JOURNAL OF NEUROSCIENCE

In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor  5 Subtype-Selective Inverse Agonist

(2009) J. R. Atack et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

(2009) Jessica A. Cardin et al.   NATURE

GABAB Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K+ Channels

(2009) Pan-Yue Deng et al.   NEURON

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Blockade of GABA(B) receptors completely reverses age-related learning impairment

(2009) C.L. Lasarge et al.   NEUROSCIENCE

Histone modifications, DNA methylation, and Schizophrenia

(2009) David P. Gavin et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

(2009) Jared W. Young et al.   PHARMACOLOGY & THERAPEUTICS

Preclinical and clinical pharmacology of the GABAA receptor α5 subtype-selective inverse agonist α5IA

(2009) John R. Atack   PHARMACOLOGY & THERAPEUTICS

Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

(2009) R. L. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subunit-Selective Modulation of GABA Type A Receptor Neurotransmission and Cognition in Schizophrenia

(2008) David A. Lewis et al.   AMERICAN JOURNAL OF PSYCHIATRY

The MATRICS Consensus Cognitive Battery, Part 1: Test Selection, Reliability, and Validity

(2008) Keith H. Nuechterlein et al.   AMERICAN JOURNAL OF PSYCHIATRY

PWZ-029, a compound with moderate inverse agonist functional selectivity at GABAA receptors containing α5 subunits, improves passive, but not active, avoidance learning in rats

(2008) Miroslav M. Savić et al.   BRAIN RESEARCH

GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice

(2008) Sawako Arai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

BL-1020: A novel antipsychotic drug with GABAergic activity and low catalepsy, is efficacious in a rat model of schizophrenia

(2008) Yona Geffen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A Mutual Prodrug Ester of GABA and Perphenazine Exhibits Antischizophrenic Efficacy with Diminished Extrapyramidal Effects

(2008) Abraham Nudelman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Influence on Contextual Memory: Physiochemical Properties Associated with Selectivity of Benzodiazepine Ligands at GABAAReceptors Containing the α5 Subunit

(2008) Danni Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Which GABAA Receptor Subunits Are Necessary for Tonic Inhibition in the Hippocampus?

(2008) J. Glykys et al.   JOURNAL OF NEUROSCIENCE

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE

The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear

(2008) T. W. Bredy et al.   LEARNING & MEMORY

Large recurrent microdeletions associated with schizophrenia

(2008) Hreinn Stefansson et al.   NATURE

The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats

(2008) Andrea Bari et al.   Nature Protocols

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON

Multifunctional receptor-directed drugs for disorders of the central nervous system

(2008) Jerry J. Buccafusco   Neurotherapeutics

RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

(2008) Theresa M. Ballard et al.   PSYCHOPHARMACOLOGY

GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia

(2008) G. Gonzalez-Burgos et al.   SCHIZOPHRENIA BULLETIN

CNTRICS Final Task Selection: Executive Control

(2008) D. M. Barch et al.   SCHIZOPHRENIA BULLETIN

Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations

(2008) T. Klausberger et al.   SCIENCE

Chandelier cartridges in the prefrontal cortex are reduced in isolation reared rats

(2008) Claire Bloomfield et al.   SYNAPSE

Hippocampal α5 subunit-containing GABAA receptors are involved in the development of the latent inhibition effect

(2007) T.V. Gerdjikov et al.   NEUROBIOLOGY OF LEARNING AND MEMORY