Article
Psychiatry
David Hough, Alice R. Mao, Michael Aman, Reymundo Lozano, Constance Smith-Hicks, Veronica Martinez-Cerdeno, Michael Derby, Zachary Rome, Niel Malan, Robert L. Findling
Summary: Suramin may improve core symptoms of autism spectrum disorder by restoring normal mitochondrial function and reducing neuro-inflammation. A 14-week study on boys aged 4-15 years showed a trend of improvement in the 10 mg/kg suramin group based on the Aberrant Behavior Checklist of Core Symptoms (ABC-Core) and the Clinical Global Impressions-Improvement (CGI-I) assessment, although the improvements were not statistically significant.
ANNALS OF GENERAL PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Soile Tuovinen, Katri Raikkonen, Elisa Holmlund-Suila, Helena Hauta-Alus, Otto Helve, Jenni Rosendahl, Maria Enlund-Cerullo, Eero Kajantie, Saara Valkama, Heli Viljakainen, Outi Makitie, Sture Andersson, Kati Heinonen
Summary: Higher-than-standard doses of vitamin D3 do not provide systematic benefits for child neurodevelopment up to 2 years of age. Further studies are warranted to evaluate potential nonbeneficial effects and safety of higher doses.
Article
Genetics & Heredity
Charlotte M. Pretzsch, Dorothea L. Floris, Bogdan Voinescu, Malka Elsahib, Maria A. Mendez, Robert Wichers, Laura Ajram, Glynis Ivin, Martin Heasman, Elise Pretzsch, Steven Williams, Declan G. M. Murphy, Eileen Daly, Grainne M. McAlonan
Summary: The study identified differences in striatal functional connectivity between individuals with ASD and neurotypicals, with CBDV being able to reduce hyperconnectivity in ASD patients to a neurotypical level. Methodological limitations restrict the generalizability of the results, but provide preliminary evidence for improving ASD symptoms.
Article
Genetics & Heredity
Nicky Daniels, Matthijs Moerkerke, Jean Steyaert, Annelies Bamps, Edward Debbaut, Jellina Prinsen, Tiffany Tang, Stephanie Van der Donck, Bart Boets, Kaat Alaerts
Summary: This study examined the efficacy of multiple-dose oxytocin administration in children with autism spectrum disorder (ASD). The results showed that both the oxytocin and placebo groups experienced improvements in social responsiveness, but these improvements were not specifically related to oxytocin administration. Interestingly, participants who initially received placebo and later switched to oxytocin showed significant improvement in social responsiveness. Furthermore, children who received psychosocial trainings along with oxytocin administration demonstrated a more pronounced improvement.
Article
Nutrition & Dietetics
Xue-Jun Kong, Jun Liu, Kevin Liu, Madelyn Koh, Hannah Sherman, Siyu Liu, Ruiyi Tian, Piyawat Sukijthamapan, Jiuju Wang, Michelle Fong, Lei Xu, Cullen Clairmont, Min-Seo Jeong, Alice Li, Maria Lopes, Veronica Hagan, Tess Dutton, Suk-Tak (Phoebe) Chan, Hang Lee, Amy Kendall, Kenneth Kwong, Yiqing Song
Summary: The combination therapy of probiotics PS128 and oxytocin has shown significant therapeutic effects on individuals with ASD, including improvements in social behavior and overall clinical outcomes. Additionally, positive changes in gut microbiome were observed after combination therapy, which may be closely related to the improvement in social cognition in patients.
Article
Multidisciplinary Sciences
Yuan Dai, Lingli Zhang, Juehua Yu, Xin Zhou, Hua He, Yiting Ji, Kai Wang, Xiujuan Du, Xin Liu, Yun Tang, Shining Deng, Christelle Langley, Wei-Guang Li, Jun Zhang, Jianfeng Feng, Barbara J. Sahakian, Qiang Luo, Fei Li
Summary: This study conducted a randomized, double-blind, placebo-controlled trial on children aged 3-6 with autism spectrum disorder (ASD) to investigate the efficacy, safety, and neural mechanism of bumetanide. The results showed that bumetanide treatment was significantly better in reducing the severity of symptoms compared to placebo, and the clinical improvement was associated with a decrease in insular GABA levels. Further multi-center trials are needed to confirm the clinical significance of these findings.
Article
Psychology, Developmental
Laura L. Corona, Liliana Wagner, Madison Hooper, Amy Weitlauf, Tori E. Foster, Jeffrey Hine, Alexandra Miceli, Amy Nicholson, Caitlin Stone, Alison Vehorn, Zachary Warren
Summary: This study investigates two approaches to tele-assessment for autism spectrum disorder (ASD) in toddlers and finds a diagnostic agreement of 92%. Children inaccurately identified as having ASD by tele-assessment were younger and had higher developmental and adaptive behavior scores than children accurately diagnosed with ASD. Both clinicians and families reported satisfaction with tele-assessment procedures.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Genetics & Heredity
J. Fastman, J. Foss-Feig, Y. Frank, D. Halpern, H. Harony-Nicolas, C. Layton, S. Sandin, P. Siper, L. Tang, P. Trelles, J. Zweifach, J. D. Buxbaum, A. Kolevzon
Summary: This study aimed to assess the efficacy and safety of intranasal oxytocin for treating core symptoms of autism spectrum disorder (ASD) in children with Phelan-McDermid syndrome (PMS). Results showed that intranasal oxytocin did not significantly improve the core symptoms of ASD in children with PMS, and no serious adverse events were reported during the study.
Article
Genetics & Heredity
Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Hua Liu, Anita A. Panjwani, Li-Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Jill James, Richard E. Frye, Jed W. Fahey
Summary: Sulforaphane showed small yet non-statistically significant changes in children with ASD in terms of clinical effects, with caregivers' assessments showing significant improvements in secondary outcome measures compared to placebo. Several biomarkers correlated to clinical improvements with SF, which was well tolerated and safe.
Article
Psychology, Developmental
Jessica M. Schwartzman, Maria Estefania Millan, Mirko Uljarevic, Grace W. Gengoux
Summary: This study investigated the impact of an 8-week AMOR intervention on parents of children with autism spectrum disorder (ASD), showing significant gains in resilience, stress management, and mental health symptoms for AMOR parents. These findings suggest promise for resilience interventions in this population.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Psychiatry
Fumiyo Oshima, William Mandy, Mikuko Seto, Minako Hongo, Aki Tsuchiyagaito, Yoshiyuki Hirano, Chihiro Sutoh, Siqing Guan, Yusuke Nitta, Yoshihito Ozawa, Yohei Kawasaki, Toshiyuki Ohtani, Jiro Masuya, Noriko Takahashi, Noriyuki Sato, Shizuka Nakamura, Akiko Nakagawa, Eiji Shimizu
Summary: The study found that the ACAT program has a positive impact on increasing understanding of autistic attributes among autistic adolescents and their parents/guardians, reducing treatment stigma, and improving mental health for autistic adolescents. However, it does not significantly affect the mental health and adaptive skills of parents/guardians.
Article
Psychology, Developmental
Lucia Billeci, Alejandro Luis Callara, Letizia Guiducci, Margherita Prosperi, Maria Aurora Morales, Sara Calderoni, Filippo Muratori, Elisa Santocchi
Summary: This study investigates the effects of probiotics on brain electrical activity in children with autism spectrum disorder. The results suggest that probiotics may lead to a shift in brain activity towards a more typical pattern, with decreased power in certain brain regions and increased coherence in specific frequency bands. The findings also highlight the importance of further research to better understand the mechanistic links between probiotics supplementation and changes in brain activity in autism spectrum disorder.
Article
Psychology, Developmental
Pamela Rosenthal Rollins, Adrienne De Froy, Michelle Campbell, Renee Thibodeau Hoffman
Summary: The study found that Pathways is a potential early childhood intervention program and mutual gaze is an active ingredient for social and communication development. The Pathways group showed significant improvements in social measures, communicative synchrony, and adaptive functioning compared to the services-as-usual group and communication group.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2021)
Article
Medicine, Research & Experimental
Xiang Feng, Quanrui Jiang, Yuxing Zhang, Tao Li, Wei Wei, Jun Yu, Wu Li, Jiangshan Li
Summary: This study aims to compare the efficacy of Tuina and conventional treatment in children with ASD. The study will evaluate the effectiveness and safety of Tuina in the treatment of ASD and provide reliable evidence for the management of patients with ASD.
Article
Clinical Neurology
Hidenori Yamasue, Masaki Kojima, Hitoshi Kuwabara, Miho Kuroda, Kaori Matsumoto, Chieko Kanai, Naoko Inada, Keiho Owada, Keiko Ochi, Nobutaka Ono, Seico Benner, Tomoyasu Wakuda, Yosuke Kameno, Jun Inoue, Taeko Harada, Kenji Tsuchiya, Kazuo Umemura, Aya Yamauchi, Nanayo Ogawa, Itaru Kushima, Norio Ozaki, Satoshi Suyama, Takuya Saito, Yukari Uemura, Junko Hamada, Yukiko Kano, Nami Honda, Saya Kikuchi, Moe Seto, Hiroaki Tomita, Noriko Miyoshi, Megumi Matsumoto, Yuko Kawaguchi, Koji Kanai, Manabu Ikeda, Itta Nakamura, Shuichi Isomura, Yoji Hirano, Toshiaki Onitsuka, Hirotaka Kosaka, Takashi Okada
Summary: Intranasal oxytocin has the potential to be a novel therapy for autism spectrum disorder, but the efficacy of repeated administrations is inconsistent. This study tested the effect of TTA-121, a new formulation of intranasal oxytocin with improved bioavailability, on the core symptoms of autism spectrum disorder and determined the dose-response relationship. The findings showed that TTA-121 at a dose of 6 U per day significantly improved the reciprocity score, indicating potential benefits for individuals with autism spectrum disorder.
Letter
Public, Environmental & Occupational Health
Kaimin Li, Yan Wu, Kefeng Li
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Article
Neurosciences
Lisa E. Mash, Annika C. Linke, Yangfeifei Gao, Molly Wilkinson, Michael A. Olson, R. Joanne Jao Keehn, Ralph-Axel Mueller
Summary: This study evaluated whole-brain lag patterns in adolescents with ASD and their typically developing peers, finding changes in lag structure during task performance but no significant differences between groups in resting state. Additionally, lag patterns were influenced by arterial transit time.
BRAIN CONNECTIVITY
(2022)
Article
Behavioral Sciences
Timothy Adamos, Leanne Chukoskie, Jeanne Townsend, Doris Trauner
Summary: Spatial neglect is a common feature following right hemisphere damage in adults, but less is known about spatial inattention in children with early brain damage. This study found that children with LH lesions showed more extensive attentional deficits compared to children with RH lesions, with impairments in attention orienting and disengagement. Children with RH lesions were most impaired in orienting and disengagement on their contralesional side.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Letter
Multidisciplinary Sciences
Jinping Zheng, Kaiqiang Wang, Yuefei Wang, Kefeng Li
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Psychology, Developmental
Yukari Takarae, Anthony Zanesco, Brandon Keehn, Leanne Chukoskie, Ralph-Axel Muller, Jeanne Townsend
Summary: EEG microstates were used to investigate differences between children with Autism Spectrum Development (ASD) and typically developing (TD) participants. The study found that the frequency and global explained variance (GEV) of a specific microstate were lower in the ASD group, while the duration of the same microstate was correlated with ASD-related behaviors. In the TD group, the duration of this microstate was also correlated with participant age and overall alpha power. Another microstate showed higher signal strength and GEV in the ASD group, with different topographical patterns between groups.
DEVELOPMENTAL SCIENCE
(2022)
Article
Behavioral Sciences
Janice Hau, Ashley Baker, Chantal Chaaban, Jiwandeep S. Kohli, R. Joanne Jao Keehn, Annika C. Linke, Lisa E. Mash, Molly Wilkinson, Mikaela K. Kinnear, Ralph-Axel Muller, Ruth A. Carper
Summary: Individuals with autism spectrum disorder (ASD) often have impairments in motor skills, especially in the control of fingers and hands. This study found that the morphology and connectivity of the hand knob area in the sensorimotor cortex were altered in middle-aged adults with ASD, potentially making them more susceptible to motor decline in old age.
Article
Biochemistry & Molecular Biology
Kefeng Li, Martin Schon, Jane C. Naviaux, Jonathan M. Monk, Nikoleta Alchus-Laiferova, Lin Wang, Igor Straka, Peter Matejicka, Peter Valkovic, Jozef Ukropec, Mark A. Tarnopolsky, Robert K. Naviaux, Barbara Ukropcova
Summary: This study used liquid chromatography-tandem mass spectrometry to analyze metabolomics in the cerebrospinal fluid of 19 young healthy adults before and after acute endurance exercise, revealing significant metabolic changes primarily involving purines, pyrimidines, amino acids, fatty acid oxidation, and other pathways. Furthermore, a crucial metabolic communication channel was identified between the brain and body, with over 80% of the changes in the cerebrospinal fluid linked to mitochondrial and metabolic alterations induced by ATP signaling.
Review
Food Science & Technology
Kefeng Li, Henry Hoi Yee Tong, Yuwei Chen, Yizhu Sun, Jing Wang
Summary: Critical illness leads to numerous deaths, especially during the COVID-19 pandemic. Patients with critical illness often suffer from systemic metabolic disorders and malnutrition. The advancement of metabolomics technology has enabled its broader applications in critical care nutrition.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Pediatrics
Kefeng Li, Kerri Bertrand, Jane C. Naviaux, Jonathan M. Monk, Alan Wells, Lin Wang, Sai Sachin Lingampelly, Robert K. Naviaux, Christina Chambers
Summary: The chemical analysis of human milk can predict the risk of neurodevelopmental delay in infants, allowing for early interventions before symptoms appear.
PEDIATRIC RESEARCH
(2023)
Article
Psychology, Clinical
Lisa E. E. Mash, Lisa S. S. Kahalley, M. Fatih Okcu, David R. R. Grosshans, Arnold C. C. Paulino, Heather Stancel, Luz De Leon, Elisabeth Wilde, Nilesh Desai, Zili D. D. Chu, William E. E. Whitehead, Murali Chintagumpala, Kimberly P. P. Raghubar
Summary: This study compared the effects of photon radiotherapy (XRT) and proton radiotherapy (PRT) on verbal memory in pediatric brain tumor survivors. The results showed that PRT was associated with better verbal learning and recall compared to XRT. The PRT group more frequently used semantic clustering strategies, which aided in encoding and retrieval. Encoding ability was associated with higher intellectual and adaptive functioning, and fewer concerns about day-to-day attention and cognitive regulation.
Article
Environmental Sciences
Kefeng Li, Jane C. Naviaux, Sai Sachin Lingampelly, Lin Wang, Jonathan M. Monk, Claire M. Taylor, Clare Ostle, Sonia Batten, Robert K. Naviaux
Summary: The Continuous Plankton Recorder (CPR) Survey is a long-term and extensive marine plankton sampling program. This study investigated the feasibility of using CPR samples to monitor marine pollution trends. The results showed the presence of various pollutants in plankton, with a decrease in their amounts over the past two decades.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Oncology
Lisa E. Mash, Lisa S. Kahalley, Kimberly P. Raghubar, Naomi J. Goodrich-Hunsaker, Tracy J. Abildskov, Luz A. De Leon, Marianne MacLeod, Heather Stancel, Kelley Parsons, Brian Biekman, Nilesh K. Desai, David R. Grosshans, Arnold C. Paulino, Zili D. Chu, William E. Whitehead, Mehmet Fatih Okcu, Murali Chintagumpala, Elisabeth A. Wilde
Summary: Research has shown that pediatric brain tumor patients who undergo photon radiotherapy may experience more cognitive problems and white matter change compared to those who receive proton therapy. This study found that the cognitive functioning and white matter damage of pediatric brain tumor survivors treated with proton therapy were similar to healthy individuals, while survivors treated with photon therapy had more cognitive problems and white matter change. These findings suggest that proton therapy may lead to better long-term cognitive outcomes by protecting healthy brain tissue.
Letter
Multidisciplinary Sciences
Jennifer Sills
Article
Education & Educational Research
Brooke Hollister, Praveen Nair, Sloan Hill-Lindsay, Leanne Chukoskie
Summary: The COVID-19 pandemic has forced universities to move their courses online, and this study explores the online learning experience of undergraduate students at a large public research institution. The findings suggest that students have struggled with engagement in live lectures, connectivity with peers and instructors, and managing the pace of coursework. However, students have a positive impression of their instructional staff and feel more comfortable asking and answering questions in online classes.
FRONTIERS IN EDUCATION
(2022)
Review
Computer Science, Interdisciplinary Applications
Bhanuka Mahanama, Yasith Jayawardana, Sundararaman Rengarajan, Gavindya Jayawardena, Leanne Chukoskie, Joseph Snider, Sampath Jayarathna
Summary: This paper reviews prior research on eye movements and pupil measures, discussing the various methods of gaze measurement and their characteristics. It also examines the applications, benefits, and practical challenges of these measures, as well as providing recommendations for future eye-tracking research.
FRONTIERS IN COMPUTER SCIENCE
(2022)